Micronization of insulin by high pressure homogenization

The aim of this study was to establish the high pressure homogenization of proteins in non-aqueous suspension as an alternative method for classical micronization strategies and to investigate the effect of high pressure on protein stability and bioactivity. The influence of drug loading, homogeniza...

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Veröffentlicht in:	Pharmaceutical research 2006-09, Vol.23 (9), p.2220-2229
Hauptverfasser:	MASCHKE, Angelika, CALI, Nadia, APPEL, Bernhard, KIERMAIER, Josef, BLUNK, Torsten, GÖPFERICH, Achim
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Biological and medical sciences Chromatography, High Pressure Liquid Drug Compounding - methods Drug Stability Excipients General pharmacology Homogenization Hypoglycemic Agents - administration & dosage Insulin Insulin - administration & dosage Mass Spectrometry Medical sciences Microscopy, Electron, Scanning Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology Pharmacology. Drug treatments Powders Pressure Proteins Temperature Temperature effects Triglycerides
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