The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4

Our previous studies have revealed that the signaling protein BCL10 plays a major role in adaptive immunity by mediating NF-kappaB activation in the LPS/TLR4 pathway. In this study, we show that IRAK-1 acts as the essential upstream adaptor that recruits BCL10 to the TLR4 signaling complex and media...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2006-09, Vol.281 (36), p.26029-26040
Hauptverfasser:	Dong, Wei, Liu, Yingle, Peng, Jinhong, Chen, Lu, Zou, Tingting, Xiao, Huazhong, Liu, Zhengxue, Li, Wen, Bu, Yiwen, Qi, Yipeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - chemistry Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Amino Acid Sequence Animals B-Cell CLL-Lymphoma 10 Protein Caspases - genetics Caspases - metabolism Cell Line Dimerization Humans Interleukin-1 Receptor-Associated Kinases - chemistry Interleukin-1 Receptor-Associated Kinases - genetics Interleukin-1 Receptor-Associated Kinases - metabolism Lipopolysaccharides - immunology Macrophages - cytology Macrophages - metabolism MAP Kinase Kinase Kinases - genetics MAP Kinase Kinase Kinases - metabolism Mice Molecular Sequence Data Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein Neoplasm Proteins - genetics Neoplasm Proteins - metabolism NF-kappa B - metabolism Nuclear Proteins - metabolism Protein Structure, Quaternary RNA Interference Signal Transduction - physiology TNF Receptor-Associated Factor 6 - genetics TNF Receptor-Associated Factor 6 - metabolism Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!