Novel Autologous Cell Therapy in Ischemic Limb Disease Through Growth Factor Secretion by Cultured Adipose Tissue–Derived Stromal Cells

OBJECTIVE—The delivery of autologous progenitor cells into ischemic tissue of patients is emerging as a novel therapeutic option. Here, we report the potential impact of cultured adipose tissue–derived cells (ADSC) on angiogenic cell therapy. METHOD AND RESULTS—ADSC were isolated from C57Bl/6 mouse...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2005-12, Vol.25 (12), p.2542-2547
Hauptverfasser:	Nakagami, Hironori, Maeda, Kazuhisa, Morishita, Ryuichi, Iguchi, Sota, Nishikawa, Tomoyuki, Takami, Yoichi, Kikuchi, Yasushi, Saito, Yukihiro, Tamai, Katsuto, Ogihara, Toshio, Kaneda, Yasufumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - cytology Angiopoietin-1 - metabolism Angiopoietin-1 - secretion Animals Aorta - cytology Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Blood vessels and receptors Blood. Blood coagulation. Reticuloendothelial system Cardiology. Vascular system Cell Division Cell Movement Cell Survival Cells, Cultured Cytokines - metabolism Cytokines - secretion Disease Models, Animal Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Endothelium, Vascular - cytology Fundamental and applied biological sciences. Psychology Growth Substances - metabolism Growth Substances - secretion Hepatocyte Growth Factor - metabolism Hepatocyte Growth Factor - secretion Hindlimb - blood supply Humans Ischemia - pathology Ischemia - physiopathology Ischemia - therapy Medical sciences Mice Mice, Inbred C57BL Muscle, Smooth, Vascular - cytology Neovascularization, Physiologic - physiology Pharmacology. Drug treatments Placenta Growth Factor Pregnancy Proteins - metabolism Pregnancy Proteins - secretion Stromal Cells - cytology Stromal Cells - metabolism Stromal Cells - transplantation Transforming Growth Factor beta - metabolism Transforming Growth Factor beta - secretion Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor A - secretion Vertebrates: cardiovascular system
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