Factors Associated With Dyspnea in Adult Patients With Sickle Cell Disease

Objective: The aim of this prospective study was to determine the cardiorespiratory factors associated with dyspnea in patients with sickle cell SS-hemoglobin disease, with a specific interest in lung vascular involvement. Measurements: Forty-nine patients (29 women and 20 men; mean [± SD] age: wome...

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Veröffentlicht in:	Chest 2005-11, Vol.128 (5), p.3336-3344
Hauptverfasser:	Delclaux, Christophe, Zerah-Lancner, Françoise, Bachir, Dora, Habibi, Anoosha, Monin, Jean-Luc, Godeau, Bertrand, Galacteros, Freídeíric
Format:	Artikel
Sprache:	eng
Schlagworte:	6-min walk test 6MWT = 6-min walk test ACS = acute chest syndrome Adult Anemia Anemia, Sickle Cell - epidemiology Anemia, Sickle Cell - physiopathology Anemias. Hemoglobinopathies Biological and medical sciences Blood Breath Tests CANO = concentration of nitric oxide from the expansible compartment of the lung Carbon monoxide Cardiology. Vascular system Care and treatment Diagnosis Diseases of red blood cells Dlco= diffusing capacity of the lung for carbon monoxide DLNO = alveolar nitric oxide diffusing capacity DM = diffusing capacity of the alveolar-capillary membrane Dyspnea Dyspnea - epidemiology Dyspnea - physiopathology Female FENO = fraction of exhaled nitric oxide FIS = fatigue impact scale Gases HbCO = carboxyhemoglobin Hematologic and hematopoietic diseases Hemoglobin Humans lung diffusion of carbon monoxide Lung Diseases - epidemiology Lung Diseases - physiopathology Male Medical research Medical sciences MRC = modified Medical Research Council Nitric oxide Nitric Oxide - metabolism NO = nitric oxide PFT = pulmonary function test Pneumology Prospective Studies Pulmonary Alveoli - metabolism pulmonary capillary blood volume Pulmonary Diffusing Capacity Respiratory Function Tests Respiratory system : syndromes and miscellaneous diseases Risk factors RR = respiratory rate SCD = sickle cell disease Shortness of breath Sickle cell anemia Sickle cell disease Spirometry V' = expiratory flow V'NO,ALV = nitric oxide diffusing rate from tissue to alveolar air VA = alveolar volume VC = pulmonary capillary blood volume available for gas exchange VOC = vasoocclusive crisis
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