Celecoxib, ibuprofen, and the antiplatelet effect of aspirin in patients with osteoarthritis and ischemic heart disease

Background and Objective We performed a placebo‐controlled, randomized study to address whether celecoxib or ibuprofen undermines the functional range of inhibition of platelet cyclooxygenase (COX)–1 activity by aspirin in patients with osteoarthritis and stable ischemic heart disease. Methods Twent...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2006-09, Vol.80 (3), p.264-274
Hauptverfasser:	Renda, Giulia, Tacconelli, Stefania, Capone, Marta L., Sacchetta, Daniele, Santarelli, Francesco, Sciulli, Maria G., Zimarino, Marco, Grana, Marilena, D'Amelio, Elisabetta, Zurro, Maria, Price, Thomas S., Patrono, Carlo, De Caterina, Raffaele, Patrignani, Paola
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - pharmacology Aged Arachidonic Acid - pharmacology Aspirin - administration & dosage Aspirin - therapeutic use Aspirin - urine Biological and medical sciences Cardiology. Vascular system Celecoxib Coronary heart disease Diseases of the osteoarticular system Double-Blind Method Drug Administration Schedule Drug Therapy, Combination Female Heart Humans Ibuprofen - administration & dosage Ibuprofen - therapeutic use Ibuprofen - urine Male Medical sciences Middle Aged Miscellaneous. Osteoarticular involvement in other diseases Myocardial Ischemia - blood Myocardial Ischemia - drug therapy Osteoarthritis Osteoarthritis - blood Osteoarthritis - drug therapy Pharmacology. Drug treatments Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - administration & dosage Platelet Aggregation Inhibitors - therapeutic use Platelet Aggregation Inhibitors - urine Platelet Function Tests - methods Pyrazoles - administration & dosage Pyrazoles - therapeutic use Pyrazoles - urine Sulfonamides - administration & dosage Sulfonamides - therapeutic use Sulfonamides - urine Thromboxane B2 - analogs & derivatives Thromboxane B2 - blood Thromboxane B2 - urine Treatment Outcome
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