Immunohistochemical demonstration of gonadotropin-releasing hormone receptors in prostate carcinoma
The antiandrogen and gonadotropin-releasing hormone (Gn-RH) analogue treatment of prostate carcinoma is based on decreased proliferative and increased apoptotic activity of tumor cells, induced by androgen ablation. Gn-RH analogues decrease the serum level of androgens by breaking the pituitary-gona...
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| Veröffentlicht in: | Urologic oncology 2005-11, Vol.23 (6), p.399-401 |
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| creator | Szabó, Janos Végh, Attila Rácz, Gergő Szende, Béla |
| description | The antiandrogen and gonadotropin-releasing hormone (Gn-RH) analogue treatment of prostate carcinoma is based on decreased proliferative and increased apoptotic activity of tumor cells, induced by androgen ablation. Gn-RH analogues decrease the serum level of androgens by breaking the pituitary-gonadal axis, but increasing evidence points to the direct effect of Gn-RH analogues on tumor cells. Immunohistochemical demonstration of Gn-RH receptors recently became possible. Cryostat and paraffin sections of prostate biopsy samples of 10 untreated patients with prostate carcinoma (T2−T3, Gleason score 5−8) were investigated for Gn-RH receptors (Gn-RHR) and androgen receptors, respectively, using the immunoperoxidase method. Membrane bound, focal Gn-RHR positivity was found in 5 samples. Nuclear androgen receptor positivity appeared in 7 samples. No correlation between Gn-RHR and androgen receptor positivity was found, neither receptor status and tumor-nodes-metastasis stage nor Gleason score could be related to each other. Correlation between Gn-RHR positivity and response to luteinizing hormone-releasing hormone analogue treatment will be investigated further. |
| doi_str_mv | 10.1016/j.urolonc.2005.04.001 |
| format | Article |
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Gn-RH analogues decrease the serum level of androgens by breaking the pituitary-gonadal axis, but increasing evidence points to the direct effect of Gn-RH analogues on tumor cells. Immunohistochemical demonstration of Gn-RH receptors recently became possible. Cryostat and paraffin sections of prostate biopsy samples of 10 untreated patients with prostate carcinoma (T2−T3, Gleason score 5−8) were investigated for Gn-RH receptors (Gn-RHR) and androgen receptors, respectively, using the immunoperoxidase method. Membrane bound, focal Gn-RHR positivity was found in 5 samples. Nuclear androgen receptor positivity appeared in 7 samples. No correlation between Gn-RHR and androgen receptor positivity was found, neither receptor status and tumor-nodes-metastasis stage nor Gleason score could be related to each other. Correlation between Gn-RHR positivity and response to luteinizing hormone-releasing hormone analogue treatment will be investigated further.</description><identifier>ISSN: 1078-1439</identifier><identifier>EISSN: 1873-2496</identifier><identifier>DOI: 10.1016/j.urolonc.2005.04.001</identifier><identifier>PMID: 16301116</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Biological and medical sciences ; Carcinoma ; Cell Nucleus - metabolism ; Gonadotropin-releasing hormone receptor ; Humans ; Immunohistochemistry ; Immunoperoxidase ; Male ; Medical sciences ; Middle Aged ; Neoplasm Staging ; Nephrology. Urinary tract diseases ; Prostate ; Prostatic Neoplasms - metabolism ; Prostatic Neoplasms - pathology ; Receptors, Androgen - metabolism ; Receptors, LHRH - metabolism ; Tumors ; Tumors of the urinary system ; Urinary tract. 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Gn-RH analogues decrease the serum level of androgens by breaking the pituitary-gonadal axis, but increasing evidence points to the direct effect of Gn-RH analogues on tumor cells. Immunohistochemical demonstration of Gn-RH receptors recently became possible. Cryostat and paraffin sections of prostate biopsy samples of 10 untreated patients with prostate carcinoma (T2−T3, Gleason score 5−8) were investigated for Gn-RH receptors (Gn-RHR) and androgen receptors, respectively, using the immunoperoxidase method. Membrane bound, focal Gn-RHR positivity was found in 5 samples. Nuclear androgen receptor positivity appeared in 7 samples. No correlation between Gn-RHR and androgen receptor positivity was found, neither receptor status and tumor-nodes-metastasis stage nor Gleason score could be related to each other. Correlation between Gn-RHR positivity and response to luteinizing hormone-releasing hormone analogue treatment will be investigated further.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Carcinoma</subject><subject>Cell Nucleus - metabolism</subject><subject>Gonadotropin-releasing hormone receptor</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Immunoperoxidase</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Prostate</subject><subject>Prostatic Neoplasms - metabolism</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Receptors, Androgen - metabolism</subject><subject>Receptors, LHRH - metabolism</subject><subject>Tumors</subject><subject>Tumors of the urinary system</subject><subject>Urinary tract. 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Urinary tract diseases</topic><topic>Prostate</topic><topic>Prostatic Neoplasms - metabolism</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Receptors, Androgen - metabolism</topic><topic>Receptors, LHRH - metabolism</topic><topic>Tumors</topic><topic>Tumors of the urinary system</topic><topic>Urinary tract. Prostate gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Szabó, Janos</creatorcontrib><creatorcontrib>Végh, Attila</creatorcontrib><creatorcontrib>Rácz, Gergő</creatorcontrib><creatorcontrib>Szende, Béla</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Urologic oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Szabó, Janos</au><au>Végh, Attila</au><au>Rácz, Gergő</au><au>Szende, Béla</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunohistochemical demonstration of gonadotropin-releasing hormone receptors in prostate carcinoma</atitle><jtitle>Urologic oncology</jtitle><addtitle>Urol Oncol</addtitle><date>2005-11-01</date><risdate>2005</risdate><volume>23</volume><issue>6</issue><spage>399</spage><epage>401</epage><pages>399-401</pages><issn>1078-1439</issn><eissn>1873-2496</eissn><abstract>The antiandrogen and gonadotropin-releasing hormone (Gn-RH) analogue treatment of prostate carcinoma is based on decreased proliferative and increased apoptotic activity of tumor cells, induced by androgen ablation. Gn-RH analogues decrease the serum level of androgens by breaking the pituitary-gonadal axis, but increasing evidence points to the direct effect of Gn-RH analogues on tumor cells. Immunohistochemical demonstration of Gn-RH receptors recently became possible. Cryostat and paraffin sections of prostate biopsy samples of 10 untreated patients with prostate carcinoma (T2−T3, Gleason score 5−8) were investigated for Gn-RH receptors (Gn-RHR) and androgen receptors, respectively, using the immunoperoxidase method. Membrane bound, focal Gn-RHR positivity was found in 5 samples. Nuclear androgen receptor positivity appeared in 7 samples. No correlation between Gn-RHR and androgen receptor positivity was found, neither receptor status and tumor-nodes-metastasis stage nor Gleason score could be related to each other. Correlation between Gn-RHR positivity and response to luteinizing hormone-releasing hormone analogue treatment will be investigated further.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>16301116</pmid><doi>10.1016/j.urolonc.2005.04.001</doi><tpages>3</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Biological and medical sciences Carcinoma Cell Nucleus - metabolism Gonadotropin-releasing hormone receptor Humans Immunohistochemistry Immunoperoxidase Male Medical sciences Middle Aged Neoplasm Staging Nephrology. Urinary tract diseases Prostate Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Receptors, Androgen - metabolism Receptors, LHRH - metabolism Tumors Tumors of the urinary system Urinary tract. Prostate gland |
| title | Immunohistochemical demonstration of gonadotropin-releasing hormone receptors in prostate carcinoma |
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