An attempt to define allergen-specific molecular surface features: a bioinformatic approach
Allergens are proteins that elicit T helper lymphocyte type 2 (Th2) responses culminating in IgE antibody production and allergic disease. However, we have no answer to the fundamental question of why certain proteins are allergens, while others are not. We hypothesized that analysis of the surface...
Gespeichert in:
| Veröffentlicht in: | Bioinformatics 2005-12, Vol.21 (23), p.4201-4204 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 4204 |
|---|---|
| container_issue | 23 |
| container_start_page | 4201 |
| container_title | Bioinformatics |
| container_volume | 21 |
| creator | Furmonaviciene, Ruta Sutton, Brian J. Glaser, Fabian Laughton, Charlie A. Jones, Nick Sewell, Herb F. Shakib, Farouk |
| description | Allergens are proteins that elicit T helper lymphocyte type 2 (Th2) responses culminating in IgE antibody production and allergic disease. However, we have no answer to the fundamental question of why certain proteins are allergens, while others are not. We hypothesized that analysis of the surface of diverse allergens may reveal common structural features which might enable them to be recognized as Th2-inducing antigens by cells of the innate immune system. We have therefore used the ConSurf server to search for allergen-specific motifs. This has enabled us to identify residue conservation patterns in the homologues of Ara t 8 (plant profilin), Act c 1 (actinidin), Bet v 1 (plant pathogenesis-related protein) and Ves v 5 (venom allergen). The results demonstrate the presence of allergen-specific patches consisting of an unusually high proportion of surface-exposed hydrophobic residues. The patches that have been identified may represent molecular patterns recognizable by cells of the innate immune system. Contact: farouk.shakib@nottingham.ac.uk Supplementary Information: |
| doi_str_mv | 10.1093/bioinformatics/bti700 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68820522</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>19386860</sourcerecordid><originalsourceid>FETCH-LOGICAL-c480t-702f51da49cadb3aada5514020a3565e174bac344e868b5d84bb8f8bb69cc8b83</originalsourceid><addsrcrecordid>eNqF0VtrFTEQB_Agiq3Vj6AEQd_WJpvLZn2rRVvhgOAFpD6ESXaiqXszyYJ-eyPnYKkvPiWQ30wm-RPymLMXnPXi1MUlzmFJE5To86krsWPsDjnmUrOmZaq_W_dCd400TByRBzlfM6a4lPI-OeK6ZVJIdUy-nM0USsFpLbQsdMAQZ6Qwjpi-4tzkFX0M0dNpGdFvIySatxTAIw0IZUuYX1Kgt4ahsK5pAf_tIbkXYMz46LCekE9vXn88v2x27y7enp_tGl9nK03H2qD4ALL3MDgBMICqg7KWgVBaIe-kAy-kRKONU4ORzplgnNO998YZcUKe7_vWa39smIudYvY4jjDjsmWrjakf0rb_hbwX9QrNKnz6D7xetjTXR1RjtDaskxWpPfJpyTlhsGuKE6RfljP7JyN7OyO7z6jWPTk039yEw03VIZQKnh0AZA9jSDD7mG9cJ4QxRlfX7F3MBX_-PYf03epOdMpefr6yry74h917cWWl-A01e6-U</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>198668074</pqid></control><display><type>article</type><title>An attempt to define allergen-specific molecular surface features: a bioinformatic approach</title><source>MEDLINE</source><source>Access via Oxford University Press (Open Access Collection)</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Furmonaviciene, Ruta ; Sutton, Brian J. ; Glaser, Fabian ; Laughton, Charlie A. ; Jones, Nick ; Sewell, Herb F. ; Shakib, Farouk</creator><creatorcontrib>Furmonaviciene, Ruta ; Sutton, Brian J. ; Glaser, Fabian ; Laughton, Charlie A. ; Jones, Nick ; Sewell, Herb F. ; Shakib, Farouk</creatorcontrib><description>Allergens are proteins that elicit T helper lymphocyte type 2 (Th2) responses culminating in IgE antibody production and allergic disease. However, we have no answer to the fundamental question of why certain proteins are allergens, while others are not. We hypothesized that analysis of the surface of diverse allergens may reveal common structural features which might enable them to be recognized as Th2-inducing antigens by cells of the innate immune system. We have therefore used the ConSurf server to search for allergen-specific motifs. This has enabled us to identify residue conservation patterns in the homologues of Ara t 8 (plant profilin), Act c 1 (actinidin), Bet v 1 (plant pathogenesis-related protein) and Ves v 5 (venom allergen). The results demonstrate the presence of allergen-specific patches consisting of an unusually high proportion of surface-exposed hydrophobic residues. The patches that have been identified may represent molecular patterns recognizable by cells of the innate immune system. Contact: farouk.shakib@nottingham.ac.uk Supplementary Information:</description><identifier>ISSN: 1367-4803</identifier><identifier>EISSN: 1460-2059</identifier><identifier>EISSN: 1367-4811</identifier><identifier>DOI: 10.1093/bioinformatics/bti700</identifier><identifier>PMID: 16204345</identifier><identifier>CODEN: BOINFP</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Algorithms ; Allergens - chemistry ; Amino Acid Motifs ; Amino Acid Sequence ; Biological and medical sciences ; Cell Membrane - metabolism ; Computational Biology - methods ; Crystallography, X-Ray ; Cysteine Endopeptidases - chemistry ; Desensitization, Immunologic ; Fundamental and applied biological sciences. Psychology ; General aspects ; Humans ; Hypersensitivity - immunology ; Immune System - immunology ; Immunoglobulin E - chemistry ; Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects) ; Molecular Sequence Data ; Plant Proteins - immunology ; Plants - chemistry ; Plants - immunology ; Profilins - chemistry ; Software ; T-Lymphocytes - immunology ; Th2 Cells - immunology</subject><ispartof>Bioinformatics, 2005-12, Vol.21 (23), p.4201-4204</ispartof><rights>Copyright Oxford University Press(England) Dec 1, 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c480t-702f51da49cadb3aada5514020a3565e174bac344e868b5d84bb8f8bb69cc8b83</citedby><cites>FETCH-LOGICAL-c480t-702f51da49cadb3aada5514020a3565e174bac344e868b5d84bb8f8bb69cc8b83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17338886$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16204345$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Furmonaviciene, Ruta</creatorcontrib><creatorcontrib>Sutton, Brian J.</creatorcontrib><creatorcontrib>Glaser, Fabian</creatorcontrib><creatorcontrib>Laughton, Charlie A.</creatorcontrib><creatorcontrib>Jones, Nick</creatorcontrib><creatorcontrib>Sewell, Herb F.</creatorcontrib><creatorcontrib>Shakib, Farouk</creatorcontrib><title>An attempt to define allergen-specific molecular surface features: a bioinformatic approach</title><title>Bioinformatics</title><addtitle>Bioinformatics</addtitle><description>Allergens are proteins that elicit T helper lymphocyte type 2 (Th2) responses culminating in IgE antibody production and allergic disease. However, we have no answer to the fundamental question of why certain proteins are allergens, while others are not. We hypothesized that analysis of the surface of diverse allergens may reveal common structural features which might enable them to be recognized as Th2-inducing antigens by cells of the innate immune system. We have therefore used the ConSurf server to search for allergen-specific motifs. This has enabled us to identify residue conservation patterns in the homologues of Ara t 8 (plant profilin), Act c 1 (actinidin), Bet v 1 (plant pathogenesis-related protein) and Ves v 5 (venom allergen). The results demonstrate the presence of allergen-specific patches consisting of an unusually high proportion of surface-exposed hydrophobic residues. The patches that have been identified may represent molecular patterns recognizable by cells of the innate immune system. Contact: farouk.shakib@nottingham.ac.uk Supplementary Information:</description><subject>Algorithms</subject><subject>Allergens - chemistry</subject><subject>Amino Acid Motifs</subject><subject>Amino Acid Sequence</subject><subject>Biological and medical sciences</subject><subject>Cell Membrane - metabolism</subject><subject>Computational Biology - methods</subject><subject>Crystallography, X-Ray</subject><subject>Cysteine Endopeptidases - chemistry</subject><subject>Desensitization, Immunologic</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>Humans</subject><subject>Hypersensitivity - immunology</subject><subject>Immune System - immunology</subject><subject>Immunoglobulin E - chemistry</subject><subject>Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects)</subject><subject>Molecular Sequence Data</subject><subject>Plant Proteins - immunology</subject><subject>Plants - chemistry</subject><subject>Plants - immunology</subject><subject>Profilins - chemistry</subject><subject>Software</subject><subject>T-Lymphocytes - immunology</subject><subject>Th2 Cells - immunology</subject><issn>1367-4803</issn><issn>1460-2059</issn><issn>1367-4811</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0VtrFTEQB_Agiq3Vj6AEQd_WJpvLZn2rRVvhgOAFpD6ESXaiqXszyYJ-eyPnYKkvPiWQ30wm-RPymLMXnPXi1MUlzmFJE5To86krsWPsDjnmUrOmZaq_W_dCd400TByRBzlfM6a4lPI-OeK6ZVJIdUy-nM0USsFpLbQsdMAQZ6Qwjpi-4tzkFX0M0dNpGdFvIySatxTAIw0IZUuYX1Kgt4ahsK5pAf_tIbkXYMz46LCekE9vXn88v2x27y7enp_tGl9nK03H2qD4ALL3MDgBMICqg7KWgVBaIe-kAy-kRKONU4ORzplgnNO998YZcUKe7_vWa39smIudYvY4jjDjsmWrjakf0rb_hbwX9QrNKnz6D7xetjTXR1RjtDaskxWpPfJpyTlhsGuKE6RfljP7JyN7OyO7z6jWPTk039yEw03VIZQKnh0AZA9jSDD7mG9cJ4QxRlfX7F3MBX_-PYf03epOdMpefr6yry74h917cWWl-A01e6-U</recordid><startdate>20051201</startdate><enddate>20051201</enddate><creator>Furmonaviciene, Ruta</creator><creator>Sutton, Brian J.</creator><creator>Glaser, Fabian</creator><creator>Laughton, Charlie A.</creator><creator>Jones, Nick</creator><creator>Sewell, Herb F.</creator><creator>Shakib, Farouk</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7TO</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20051201</creationdate><title>An attempt to define allergen-specific molecular surface features: a bioinformatic approach</title><author>Furmonaviciene, Ruta ; Sutton, Brian J. ; Glaser, Fabian ; Laughton, Charlie A. ; Jones, Nick ; Sewell, Herb F. ; Shakib, Farouk</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480t-702f51da49cadb3aada5514020a3565e174bac344e868b5d84bb8f8bb69cc8b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Algorithms</topic><topic>Allergens - chemistry</topic><topic>Amino Acid Motifs</topic><topic>Amino Acid Sequence</topic><topic>Biological and medical sciences</topic><topic>Cell Membrane - metabolism</topic><topic>Computational Biology - methods</topic><topic>Crystallography, X-Ray</topic><topic>Cysteine Endopeptidases - chemistry</topic><topic>Desensitization, Immunologic</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>Humans</topic><topic>Hypersensitivity - immunology</topic><topic>Immune System - immunology</topic><topic>Immunoglobulin E - chemistry</topic><topic>Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects)</topic><topic>Molecular Sequence Data</topic><topic>Plant Proteins - immunology</topic><topic>Plants - chemistry</topic><topic>Plants - immunology</topic><topic>Profilins - chemistry</topic><topic>Software</topic><topic>T-Lymphocytes - immunology</topic><topic>Th2 Cells - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Furmonaviciene, Ruta</creatorcontrib><creatorcontrib>Sutton, Brian J.</creatorcontrib><creatorcontrib>Glaser, Fabian</creatorcontrib><creatorcontrib>Laughton, Charlie A.</creatorcontrib><creatorcontrib>Jones, Nick</creatorcontrib><creatorcontrib>Sewell, Herb F.</creatorcontrib><creatorcontrib>Shakib, Farouk</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Bioinformatics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Furmonaviciene, Ruta</au><au>Sutton, Brian J.</au><au>Glaser, Fabian</au><au>Laughton, Charlie A.</au><au>Jones, Nick</au><au>Sewell, Herb F.</au><au>Shakib, Farouk</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An attempt to define allergen-specific molecular surface features: a bioinformatic approach</atitle><jtitle>Bioinformatics</jtitle><addtitle>Bioinformatics</addtitle><date>2005-12-01</date><risdate>2005</risdate><volume>21</volume><issue>23</issue><spage>4201</spage><epage>4204</epage><pages>4201-4204</pages><issn>1367-4803</issn><eissn>1460-2059</eissn><eissn>1367-4811</eissn><coden>BOINFP</coden><abstract>Allergens are proteins that elicit T helper lymphocyte type 2 (Th2) responses culminating in IgE antibody production and allergic disease. However, we have no answer to the fundamental question of why certain proteins are allergens, while others are not. We hypothesized that analysis of the surface of diverse allergens may reveal common structural features which might enable them to be recognized as Th2-inducing antigens by cells of the innate immune system. We have therefore used the ConSurf server to search for allergen-specific motifs. This has enabled us to identify residue conservation patterns in the homologues of Ara t 8 (plant profilin), Act c 1 (actinidin), Bet v 1 (plant pathogenesis-related protein) and Ves v 5 (venom allergen). The results demonstrate the presence of allergen-specific patches consisting of an unusually high proportion of surface-exposed hydrophobic residues. The patches that have been identified may represent molecular patterns recognizable by cells of the innate immune system. Contact: farouk.shakib@nottingham.ac.uk Supplementary Information:</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>16204345</pmid><doi>10.1093/bioinformatics/bti700</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1367-4803 |
| ispartof | Bioinformatics, 2005-12, Vol.21 (23), p.4201-4204 |
| issn | 1367-4803 1460-2059 1367-4811 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68820522 |
| source | MEDLINE; Access via Oxford University Press (Open Access Collection); Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Algorithms Allergens - chemistry Amino Acid Motifs Amino Acid Sequence Biological and medical sciences Cell Membrane - metabolism Computational Biology - methods Crystallography, X-Ray Cysteine Endopeptidases - chemistry Desensitization, Immunologic Fundamental and applied biological sciences. Psychology General aspects Humans Hypersensitivity - immunology Immune System - immunology Immunoglobulin E - chemistry Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects) Molecular Sequence Data Plant Proteins - immunology Plants - chemistry Plants - immunology Profilins - chemistry Software T-Lymphocytes - immunology Th2 Cells - immunology |
| title | An attempt to define allergen-specific molecular surface features: a bioinformatic approach |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T01%3A49%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=An%20attempt%20to%20define%20allergen-specific%20molecular%20surface%20features:%20a%20bioinformatic%20approach&rft.jtitle=Bioinformatics&rft.au=Furmonaviciene,%20Ruta&rft.date=2005-12-01&rft.volume=21&rft.issue=23&rft.spage=4201&rft.epage=4204&rft.pages=4201-4204&rft.issn=1367-4803&rft.eissn=1460-2059&rft.coden=BOINFP&rft_id=info:doi/10.1093/bioinformatics/bti700&rft_dat=%3Cproquest_cross%3E19386860%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=198668074&rft_id=info:pmid/16204345&rfr_iscdi=true |