Intraepithelial gammadelta+ lymphocytes maintain the integrity of intestinal epithelial tight junctions in response to infection

Intestinal epithelial integrity and permeability is dependent on intercellular tight junction (TJ) complexes. How TJ integrity is regulated remains unclear, although phosphorylation and dephosphorylation of the integral membrane protein occludin is an important determinant of TJ formation and epithe...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2006-09, Vol.131 (3), p.818-829
Hauptverfasser:	Dalton, Jane E, Cruickshank, Sheena M, Egan, Charlotte E, Mears, Rainy, Newton, Darren J, Andrew, Elizabeth M, Lawrence, Beth, Howell, Gareth, Else, Kathryn J, Gubbels, Marc-Jan, Striepen, Boris, Smith, Judith E, White, Stanley J, Carding, Simon R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Cell Membrane Permeability - immunology Disease Models, Animal Immunohistochemistry Immunoprecipitation Intercellular Junctions - metabolism Intestinal Mucosa - immunology Intestinal Mucosa - metabolism Intestinal Mucosa - parasitology Male Membrane Proteins - metabolism Mice Mice, Inbred C57BL Occludin Phosphorylation Receptors, Antigen, T-Cell, gamma-delta - genetics Receptors, Antigen, T-Cell, gamma-delta - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA - genetics T-Lymphocytes - immunology T-Lymphocytes - metabolism Toxoplasma - isolation & purification Toxoplasma - pathogenicity Toxoplasmosis, Animal - immunology Toxoplasmosis, Animal - metabolism Toxoplasmosis, Animal - pathology
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