Evaluation of the role of AMP-activated protein kinase and its downstream targets in mammalian hibernation

Mammalian hibernation requires an extensive reorganization of metabolism that typically includes a greater than 95% reduction in metabolic rate, selective inhibition of many ATP-consuming metabolic activities and a change in fuel use to a primary dependence on the oxidation of lipid reserves. We inv...

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Veröffentlicht in:	Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 2005-12, Vol.142 (4), p.374-382
Hauptverfasser:	Horman, Sandrine, Hussain, Nusrat, Dilworth, Stephen M., Storey, Kenneth B., Rider, Mark H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyl-CoA carboxylase Acetyl-CoA Carboxylase - metabolism Adipose Tissue - enzymology Adipose Tissue - metabolism AMP-Activated Protein Kinases Animals Elongation factor-2 Glycogen Synthase - immunology Glycogen Synthase - metabolism Ground squirrels Hibernation - genetics Hibernation - physiology Hormone-sensitive lipase Metabolic rate suppression Multienzyme Complexes - immunology Multienzyme Complexes - metabolism Multienzyme Complexes - physiology Peptide Elongation Factor 2 - immunology Peptide Elongation Factor 2 - metabolism Phosphorylation Protein phosphorylation Protein-Serine-Threonine Kinases - immunology Protein-Serine-Threonine Kinases - metabolism Protein-Serine-Threonine Kinases - physiology Sciuridae - physiology Serine - metabolism Sterol Esterase - immunology Sterol Esterase - metabolism Temperature Threonine - metabolism
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