Logic of the Yeast Metabolic Cycle: Temporal Compartmentalization of Cellular Processes
Budding yeast grown under continuous, nutrient-limited conditions exhibit robust, highly periodic cycles in the form of respiratory bursts. Microarray studies reveal that over half of the yeast genome is expressed periodically during these metabolic cycles. Genes encoding proteins having a common fu...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2005-11, Vol.310 (5751), p.1152-1158 |
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| creator | Tu, Benjamin P. Kudlicki, Andrzej Rowicka, Maga McKnight, Steven L. |
| description | Budding yeast grown under continuous, nutrient-limited conditions exhibit robust, highly periodic cycles in the form of respiratory bursts. Microarray studies reveal that over half of the yeast genome is expressed periodically during these metabolic cycles. Genes encoding proteins having a common function exhibit similar temporal expression patterns, and genes specifying functions associated with energy and metabolism tend to be expressed with exceptionally robust periodicity. Essential cellular and metabolic events occur in synchrony with the metabolic cycle, demonstrating that key processes in a simple eukaryotic cell are compartmentalized in time. |
| doi_str_mv | 10.1126/science.1120499 |
| format | Article |
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Microarray studies reveal that over half of the yeast genome is expressed periodically during these metabolic cycles. Genes encoding proteins having a common function exhibit similar temporal expression patterns, and genes specifying functions associated with energy and metabolism tend to be expressed with exceptionally robust periodicity. Essential cellular and metabolic events occur in synchrony with the metabolic cycle, demonstrating that key processes in a simple eukaryotic cell are compartmentalized in time.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1120499</identifier><identifier>PMID: 16254148</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Association for the Advancement of Science</publisher><subject>Algorithms ; Analysis ; Biological and medical sciences ; Cell cycle ; Cell Division ; Cellular metabolism ; Cluster Analysis ; DNA, Fungal ; Eukaryotes ; Exhibits ; Fundamental and applied biological sciences. Psychology ; Gene expression ; Gene Expression Profiling ; Gene Expression Regulation, Fungal ; Genes ; Growth, nutrition, metabolism, transports, enzymes. Molecular biology ; Metabolism ; Microbiology ; Mitochondria - metabolism ; Multivariate Analysis ; Mycology ; Oligonucleotide Array Sequence Analysis ; Oscillation ; Periodicity ; Protein metabolism ; Proteins ; Regulatory Sequences, Nucleic Acid ; Reprography ; Ribosomal proteins ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae - metabolism ; Saccharomyces cerevisiae Proteins - genetics ; Saccharomyces cerevisiae Proteins - metabolism ; Superclusters ; Transcripts (Written Records) ; Yeast ; Yeast fungi ; Yeasts ; Yeasts (Fungi)</subject><ispartof>Science (American Association for the Advancement of Science), 2005-11, Vol.310 (5751), p.1152-1158</ispartof><rights>Copyright 2005 American Association for the Advancement of Science</rights><rights>2006 INIST-CNRS</rights><rights>COPYRIGHT 2005 American Association for the Advancement of Science</rights><rights>COPYRIGHT 2005 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Nov 18, 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c713t-4715bf574421adcde976ecfcc4c830db28d461ec251390bbb1331905b3e4969e3</citedby><cites>FETCH-LOGICAL-c713t-4715bf574421adcde976ecfcc4c830db28d461ec251390bbb1331905b3e4969e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3843059$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3843059$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>315,781,785,804,2885,2886,27929,27930,58022,58255</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17293949$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16254148$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tu, Benjamin P.</creatorcontrib><creatorcontrib>Kudlicki, Andrzej</creatorcontrib><creatorcontrib>Rowicka, Maga</creatorcontrib><creatorcontrib>McKnight, Steven L.</creatorcontrib><title>Logic of the Yeast Metabolic Cycle: Temporal Compartmentalization of Cellular Processes</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Budding yeast grown under continuous, nutrient-limited conditions exhibit robust, highly periodic cycles in the form of respiratory bursts. Microarray studies reveal that over half of the yeast genome is expressed periodically during these metabolic cycles. Genes encoding proteins having a common function exhibit similar temporal expression patterns, and genes specifying functions associated with energy and metabolism tend to be expressed with exceptionally robust periodicity. Essential cellular and metabolic events occur in synchrony with the metabolic cycle, demonstrating that key processes in a simple eukaryotic cell are compartmentalized in time.</description><subject>Algorithms</subject><subject>Analysis</subject><subject>Biological and medical sciences</subject><subject>Cell cycle</subject><subject>Cell Division</subject><subject>Cellular metabolism</subject><subject>Cluster Analysis</subject><subject>DNA, Fungal</subject><subject>Eukaryotes</subject><subject>Exhibits</subject><subject>Fundamental and applied biological sciences. 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Microarray studies reveal that over half of the yeast genome is expressed periodically during these metabolic cycles. Genes encoding proteins having a common function exhibit similar temporal expression patterns, and genes specifying functions associated with energy and metabolism tend to be expressed with exceptionally robust periodicity. Essential cellular and metabolic events occur in synchrony with the metabolic cycle, demonstrating that key processes in a simple eukaryotic cell are compartmentalized in time.</abstract><cop>Washington, DC</cop><pub>American Association for the Advancement of Science</pub><pmid>16254148</pmid><doi>10.1126/science.1120499</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2005-11, Vol.310 (5751), p.1152-1158 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68817463 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; Science journals (American Association for the Advancement of Science = AAAS) |
| subjects | Algorithms Analysis Biological and medical sciences Cell cycle Cell Division Cellular metabolism Cluster Analysis DNA, Fungal Eukaryotes Exhibits Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Profiling Gene Expression Regulation, Fungal Genes Growth, nutrition, metabolism, transports, enzymes. Molecular biology Metabolism Microbiology Mitochondria - metabolism Multivariate Analysis Mycology Oligonucleotide Array Sequence Analysis Oscillation Periodicity Protein metabolism Proteins Regulatory Sequences, Nucleic Acid Reprography Ribosomal proteins Saccharomyces cerevisiae Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Superclusters Transcripts (Written Records) Yeast Yeast fungi Yeasts Yeasts (Fungi) |
| title | Logic of the Yeast Metabolic Cycle: Temporal Compartmentalization of Cellular Processes |
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