The N-Terminal A/B domain of the thyroid hormone receptor-beta2 isoform influences ligand-dependent recruitment of coactivators to the ligand-binding domain

Thyroid hormone receptors (TRs), expressed as TRalpha1, TRbeta1, and TRbeta2 isoforms, are members of the steroid hormone nuclear receptor gene superfamily, which comprises ligand-dependent transcription factors. The TR isoforms differ primarily in their N-terminal (A/B) domains, suggesting that the...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 2006-09, Vol.20 (9), p.2036-2051
Hauptverfasser:	Tian, Henghe, Mahajan, Muktar A, Wong, Chun Tung, Habeos, Ioanis, Samuels, Herbert H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites CREB-Binding Protein - genetics CREB-Binding Protein - metabolism Gene Deletion HeLa Cells Histone Acetyltransferases Humans Ligands Mutation - genetics Nuclear Receptor Coactivator 1 Protein Isoforms - genetics Protein Isoforms - metabolism Rats Thyroid Hormone Receptors beta - genetics Thyroid Hormone Receptors beta - metabolism Transcription Factors - genetics Transcription Factors - metabolism
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