Interactions of cationic porphyrins with double-stranded oligodeoxynucleotides: a study by electrospray ionisation mass spectrometry
Electrospray ionisation mass spectrometry (ESI‐MS), electrospray ionisation tandem mass spectrometry (ESI‐MS/MS) and Ultraviolet‐visible (UV–vis) spectroscopy were used to investigate the non‐covalent interactions between small oligonucleotide duplexes with the GC motif and a group of cationic meso(...
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| Veröffentlicht in: | Journal of mass spectrometry. 2005-11, Vol.40 (11), p.1439-1447 |
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| container_title | Journal of mass spectrometry. |
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| creator | Ramos, Catarina I. V. Barros, Cristina M. Fernandes, Ana M. Santana-Marques, M. G. Correia, A. J. Ferrer Tomé, João P. C. Carrilho, Maria do Carmo T. Faustino, Maria Amparo F. Tomé, Augusto C. Neves, M. G. P. M. S. Cavaleiro, J. A. S. |
| description | Electrospray ionisation mass spectrometry (ESI‐MS), electrospray ionisation tandem mass spectrometry (ESI‐MS/MS) and Ultraviolet‐visible (UV–vis) spectroscopy were used to investigate the non‐covalent interactions between small oligonucleotide duplexes with the GC motif and a group of cationic meso(N‐methylpyridynium‐4‐yl)porphyrins (four free bases with one to four positive charges, and the zinc complex of the tetracationic free base).
The results obtained point to outside binding of the porphyrins, with the binding strength increasing with the number of positive charges. Fragmentations involving losses from both chains were observed for the porphyrins with N‐methylpyridinium‐4‐yl groups in opposite meso positions. Copyright © 2005 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/jms.936 |
| format | Article |
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The results obtained point to outside binding of the porphyrins, with the binding strength increasing with the number of positive charges. Fragmentations involving losses from both chains were observed for the porphyrins with N‐methylpyridinium‐4‐yl groups in opposite meso positions. Copyright © 2005 John Wiley & Sons, Ltd.</description><identifier>ISSN: 1076-5174</identifier><identifier>EISSN: 1096-9888</identifier><identifier>DOI: 10.1002/jms.936</identifier><identifier>PMID: 16261648</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Base Sequence ; Biological and medical sciences ; cationic porphyrins ; Cations - chemistry ; Cations - metabolism ; electrospray ; Fundamental and applied biological sciences. Psychology ; Interactions. Associations ; Intermolecular phenomena ; Models, Molecular ; Molecular biophysics ; Molecular Sequence Data ; non-covalent adducts ; Oligodeoxyribonucleotides - chemistry ; Oligodeoxyribonucleotides - metabolism ; oligonucleotides ; outside binding ; Porphyrins - chemistry ; Porphyrins - metabolism ; Spectrometry, Mass, Electrospray Ionization</subject><ispartof>Journal of mass spectrometry., 2005-11, Vol.40 (11), p.1439-1447</ispartof><rights>Copyright © 2005 John Wiley & Sons, Ltd.</rights><rights>2006 INIST-CNRS</rights><rights>Copyright 2005 John Wiley & Sons, Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4146-52e9b92c1a9e40b14d0b671df0178e52f7982f61c2127c86a1838ba9cff4d0eb3</citedby><cites>FETCH-LOGICAL-c4146-52e9b92c1a9e40b14d0b671df0178e52f7982f61c2127c86a1838ba9cff4d0eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjms.936$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjms.936$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17239312$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16261648$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ramos, Catarina I. V.</creatorcontrib><creatorcontrib>Barros, Cristina M.</creatorcontrib><creatorcontrib>Fernandes, Ana M.</creatorcontrib><creatorcontrib>Santana-Marques, M. G.</creatorcontrib><creatorcontrib>Correia, A. J. Ferrer</creatorcontrib><creatorcontrib>Tomé, João P. C.</creatorcontrib><creatorcontrib>Carrilho, Maria do Carmo T.</creatorcontrib><creatorcontrib>Faustino, Maria Amparo F.</creatorcontrib><creatorcontrib>Tomé, Augusto C.</creatorcontrib><creatorcontrib>Neves, M. G. P. M. S.</creatorcontrib><creatorcontrib>Cavaleiro, J. A. S.</creatorcontrib><title>Interactions of cationic porphyrins with double-stranded oligodeoxynucleotides: a study by electrospray ionisation mass spectrometry</title><title>Journal of mass spectrometry.</title><addtitle>J. Mass Spectrom</addtitle><description>Electrospray ionisation mass spectrometry (ESI‐MS), electrospray ionisation tandem mass spectrometry (ESI‐MS/MS) and Ultraviolet‐visible (UV–vis) spectroscopy were used to investigate the non‐covalent interactions between small oligonucleotide duplexes with the GC motif and a group of cationic meso(N‐methylpyridynium‐4‐yl)porphyrins (four free bases with one to four positive charges, and the zinc complex of the tetracationic free base).
The results obtained point to outside binding of the porphyrins, with the binding strength increasing with the number of positive charges. Fragmentations involving losses from both chains were observed for the porphyrins with N‐methylpyridinium‐4‐yl groups in opposite meso positions. Copyright © 2005 John Wiley & Sons, Ltd.</description><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>cationic porphyrins</subject><subject>Cations - chemistry</subject><subject>Cations - metabolism</subject><subject>electrospray</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Interactions. Associations</subject><subject>Intermolecular phenomena</subject><subject>Models, Molecular</subject><subject>Molecular biophysics</subject><subject>Molecular Sequence Data</subject><subject>non-covalent adducts</subject><subject>Oligodeoxyribonucleotides - chemistry</subject><subject>Oligodeoxyribonucleotides - metabolism</subject><subject>oligonucleotides</subject><subject>outside binding</subject><subject>Porphyrins - chemistry</subject><subject>Porphyrins - metabolism</subject><subject>Spectrometry, Mass, Electrospray Ionization</subject><issn>1076-5174</issn><issn>1096-9888</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1TAQhSMEoqUg_gHyBligFNvJ9YMdusClDx4SIJaW40yoSxIHT6I2e344TnNFV4jVjGY-naOZk2WPGT1mlPKXlx0e60LcyQ4Z1SLXSqm7Sy9FvmGyPMgeIF5SSrUuxf3sgAkumCjVYfb7pB8hWjf60CMJDXF2ab0jQ4jDxRx9Gl_58YLUYapayHGMtq-hJqH1P0IN4XruJ9dCGH0N-IpYguNUz6SaCbTgxhhwiHYmiyjeaJPOIhIcbpYdjHF-mN1rbIvwaF-Psm_v3n7dvs_PP-1Otq_Pc1eyMl3CQVeaO2Y1lLRiZU0rIVndUCYVbHgjteKNYI4zLp0SlqlCVVa7pkkoVMVR9mzVHWL4NQGOpvPooG1tD2FCI5RKX-Hlf0GmSy6l4Al8voIu3YkRGjNE39k4G0bNkoxJyZiUTCKf7CWnqoP6lttHkYCne8Cis22T3uw83nKSF7pgi-WLlbvyLcz_8jOnH76stvlKexzh-i9t408jZCE35vvHndmenX1-w3bSnBZ_AK56txQ</recordid><startdate>200511</startdate><enddate>200511</enddate><creator>Ramos, Catarina I. V.</creator><creator>Barros, Cristina M.</creator><creator>Fernandes, Ana M.</creator><creator>Santana-Marques, M. G.</creator><creator>Correia, A. J. Ferrer</creator><creator>Tomé, João P. C.</creator><creator>Carrilho, Maria do Carmo T.</creator><creator>Faustino, Maria Amparo F.</creator><creator>Tomé, Augusto C.</creator><creator>Neves, M. G. P. M. S.</creator><creator>Cavaleiro, J. A. S.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200511</creationdate><title>Interactions of cationic porphyrins with double-stranded oligodeoxynucleotides: a study by electrospray ionisation mass spectrometry</title><author>Ramos, Catarina I. V. ; Barros, Cristina M. ; Fernandes, Ana M. ; Santana-Marques, M. G. ; Correia, A. J. Ferrer ; Tomé, João P. C. ; Carrilho, Maria do Carmo T. ; Faustino, Maria Amparo F. ; Tomé, Augusto C. ; Neves, M. G. P. M. S. ; Cavaleiro, J. A. S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4146-52e9b92c1a9e40b14d0b671df0178e52f7982f61c2127c86a1838ba9cff4d0eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>cationic porphyrins</topic><topic>Cations - chemistry</topic><topic>Cations - metabolism</topic><topic>electrospray</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Interactions. Associations</topic><topic>Intermolecular phenomena</topic><topic>Models, Molecular</topic><topic>Molecular biophysics</topic><topic>Molecular Sequence Data</topic><topic>non-covalent adducts</topic><topic>Oligodeoxyribonucleotides - chemistry</topic><topic>Oligodeoxyribonucleotides - metabolism</topic><topic>oligonucleotides</topic><topic>outside binding</topic><topic>Porphyrins - chemistry</topic><topic>Porphyrins - metabolism</topic><topic>Spectrometry, Mass, Electrospray Ionization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramos, Catarina I. V.</creatorcontrib><creatorcontrib>Barros, Cristina M.</creatorcontrib><creatorcontrib>Fernandes, Ana M.</creatorcontrib><creatorcontrib>Santana-Marques, M. G.</creatorcontrib><creatorcontrib>Correia, A. J. Ferrer</creatorcontrib><creatorcontrib>Tomé, João P. C.</creatorcontrib><creatorcontrib>Carrilho, Maria do Carmo T.</creatorcontrib><creatorcontrib>Faustino, Maria Amparo F.</creatorcontrib><creatorcontrib>Tomé, Augusto C.</creatorcontrib><creatorcontrib>Neves, M. G. P. M. S.</creatorcontrib><creatorcontrib>Cavaleiro, J. A. S.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of mass spectrometry.</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ramos, Catarina I. V.</au><au>Barros, Cristina M.</au><au>Fernandes, Ana M.</au><au>Santana-Marques, M. G.</au><au>Correia, A. J. Ferrer</au><au>Tomé, João P. C.</au><au>Carrilho, Maria do Carmo T.</au><au>Faustino, Maria Amparo F.</au><au>Tomé, Augusto C.</au><au>Neves, M. G. P. M. S.</au><au>Cavaleiro, J. A. S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interactions of cationic porphyrins with double-stranded oligodeoxynucleotides: a study by electrospray ionisation mass spectrometry</atitle><jtitle>Journal of mass spectrometry.</jtitle><addtitle>J. Mass Spectrom</addtitle><date>2005-11</date><risdate>2005</risdate><volume>40</volume><issue>11</issue><spage>1439</spage><epage>1447</epage><pages>1439-1447</pages><issn>1076-5174</issn><eissn>1096-9888</eissn><abstract>Electrospray ionisation mass spectrometry (ESI‐MS), electrospray ionisation tandem mass spectrometry (ESI‐MS/MS) and Ultraviolet‐visible (UV–vis) spectroscopy were used to investigate the non‐covalent interactions between small oligonucleotide duplexes with the GC motif and a group of cationic meso(N‐methylpyridynium‐4‐yl)porphyrins (four free bases with one to four positive charges, and the zinc complex of the tetracationic free base).
The results obtained point to outside binding of the porphyrins, with the binding strength increasing with the number of positive charges. Fragmentations involving losses from both chains were observed for the porphyrins with N‐methylpyridinium‐4‐yl groups in opposite meso positions. Copyright © 2005 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>16261648</pmid><doi>10.1002/jms.936</doi><tpages>9</tpages></addata></record> |
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| ispartof | Journal of mass spectrometry., 2005-11, Vol.40 (11), p.1439-1447 |
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| subjects | Base Sequence Biological and medical sciences cationic porphyrins Cations - chemistry Cations - metabolism electrospray Fundamental and applied biological sciences. Psychology Interactions. Associations Intermolecular phenomena Models, Molecular Molecular biophysics Molecular Sequence Data non-covalent adducts Oligodeoxyribonucleotides - chemistry Oligodeoxyribonucleotides - metabolism oligonucleotides outside binding Porphyrins - chemistry Porphyrins - metabolism Spectrometry, Mass, Electrospray Ionization |
| title | Interactions of cationic porphyrins with double-stranded oligodeoxynucleotides: a study by electrospray ionisation mass spectrometry |
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