Sphingosine-1-Phosphate Agonists Increase Macrophage Homing, Lymphocyte Contacts, and Endothelial Junctional Complex Formation in Murine Lymph Nodes

The sphingosine-1-phosphate (S1P) receptor agonist, phosphorylated FTY720 (FTY-P), causes lymphopenia, lymphocyte sequestration in mesenteric lymph nodes (MLNs), and immunosuppression. Using multiple techniques to analyze MLN cells harvested from mice treated with S1P receptor agonists, we saw a red...

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Veröffentlicht in:	Journal of Immunology 2005-12, Vol.175 (11), p.7151-7161
Hauptverfasser:	Singer, Irwin I, Tian, Min, Wickham, L. Alexandra, Lin, Jeffrey, Matheravidathu, Scaria S, Forrest, Michael J, Mandala, Suzanne, Quackenbush, Elizabeth J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Communication - immunology Endothelial Cells - drug effects Endothelial Cells - immunology Endothelial Cells - ultrastructure Endothelium, Lymphatic - drug effects Endothelium, Lymphatic - ultrastructure Endothelium, Vascular - drug effects Endothelium, Vascular - ultrastructure Female Fingolimod Hydrochloride Fluorescent Antibody Technique Immunosuppressive Agents - pharmacology Lymph Nodes - drug effects Lymph Nodes - immunology Lymphocytes - drug effects Lymphocytes - immunology Lymphocytes - metabolism Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Mesentery - immunology Mice Mice, Inbred C57BL Microscopy, Electron, Transmission Microscopy, Immunoelectron Phosphorylation Propylene Glycols - pharmacology Receptors, Lysosphingolipid - drug effects Receptors, Lysosphingolipid - immunology Receptors, Lysosphingolipid - metabolism Sphingosine - analogs & derivatives Tight Junctions - immunology Tight Junctions - ultrastructure
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