The role of oxidative stress in postoperative delirium
This study aimed to determine a marker that predicts delirium using preoperative oxidative processes in patients undergoing cardiopulmonary bypass surgery. Twelve of the 50 patients included in the study showed signs of delirium during postoperative follow-up. The Delirium Rating Scale was used in p...
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| Veröffentlicht in: | General hospital psychiatry 2006-09, Vol.28 (5), p.418-423 |
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| creator | Karlidag, Rifat Unal, Suheyla Sezer, Ozlem H. Bay Karabulut, Aysun Battaloğlu, Bektaş But, Abdülkadir Ozcan, Cemal |
| description | This study aimed to determine a marker that predicts delirium using preoperative oxidative processes in patients undergoing cardiopulmonary bypass surgery.
Twelve of the 50 patients included in the study showed signs of delirium during postoperative follow-up. The Delirium Rating Scale was used in patients with delirium according to
DSM-IV-TR in the postoperative period. Venous blood samples were obtained from the patients the day before and the day after the surgery to determine plasma antioxidant enzyme levels.
While there were no differences in preoperative superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) levels in both groups, catalase (CAT) levels were significantly lower in the delirium group. Postoperative SOD and MDA levels were also higher in the delirium group, while the GSH-Px levels were found to be lower when compared with those during the preoperative period. In the nondelirium group, the postoperative MDA and GSH-Px levels were found to be lower than preoperative levels, and postoperative SOD levels were found to be higher than preoperative levels. CAT levels were lower in the delirium group when the pre- and postoperative levels were compared in both groups. The postoperative levels of SOD, GSH-Px and CAT in the nondelirium group and MDA in the delirium group were significantly higher than preoperative levels.
Patients with low preoperative CAT levels appeared to be more susceptible to delirium than patients with higher CAT levels. |
| doi_str_mv | 10.1016/j.genhosppsych.2006.06.002 |
| format | Article |
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Twelve of the 50 patients included in the study showed signs of delirium during postoperative follow-up. The Delirium Rating Scale was used in patients with delirium according to
DSM-IV-TR in the postoperative period. Venous blood samples were obtained from the patients the day before and the day after the surgery to determine plasma antioxidant enzyme levels.
While there were no differences in preoperative superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) levels in both groups, catalase (CAT) levels were significantly lower in the delirium group. Postoperative SOD and MDA levels were also higher in the delirium group, while the GSH-Px levels were found to be lower when compared with those during the preoperative period. In the nondelirium group, the postoperative MDA and GSH-Px levels were found to be lower than preoperative levels, and postoperative SOD levels were found to be higher than preoperative levels. CAT levels were lower in the delirium group when the pre- and postoperative levels were compared in both groups. The postoperative levels of SOD, GSH-Px and CAT in the nondelirium group and MDA in the delirium group were significantly higher than preoperative levels.
Patients with low preoperative CAT levels appeared to be more susceptible to delirium than patients with higher CAT levels.</description><identifier>ISSN: 0163-8343</identifier><identifier>EISSN: 1873-7714</identifier><identifier>DOI: 10.1016/j.genhosppsych.2006.06.002</identifier><identifier>PMID: 16950378</identifier><identifier>CODEN: GHPSDB</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult and adolescent clinical studies ; Aged ; Antioxidant enzymes ; Antioxidants - physiology ; Biological and medical sciences ; Brain - physiopathology ; Cardiopulmonary Bypass - adverse effects ; Cardiopulmonary bypass surgery ; Catalase - blood ; Coronary Disease - surgery ; Delirium ; Delirium - diagnosis ; Delirium - physiopathology ; Delirium - psychology ; Female ; Free radicals ; Free Radicals - blood ; Glutathione Peroxidase - blood ; Humans ; Lipid Peroxidation - physiology ; Male ; Malondialdehyde - blood ; Medical sciences ; Middle Aged ; Neurons - physiology ; Organic mental disorders. Neuropsychology ; Oxidative Stress - physiology ; Postoperative Complications - diagnosis ; Postoperative Complications - physiopathology ; Postoperative Complications - psychology ; Predictive Value of Tests ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Risk Factors ; Superoxide Dismutase - blood</subject><ispartof>General hospital psychiatry, 2006-09, Vol.28 (5), p.418-423</ispartof><rights>2006 Elsevier Inc.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-aa63fece03a614057a1b52970a284d076bf382f06bc4df9b05211d7b97c0d56f3</citedby><cites>FETCH-LOGICAL-c408t-aa63fece03a614057a1b52970a284d076bf382f06bc4df9b05211d7b97c0d56f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S016383430600096X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18447100$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16950378$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karlidag, Rifat</creatorcontrib><creatorcontrib>Unal, Suheyla</creatorcontrib><creatorcontrib>Sezer, Ozlem H.</creatorcontrib><creatorcontrib>Bay Karabulut, Aysun</creatorcontrib><creatorcontrib>Battaloğlu, Bektaş</creatorcontrib><creatorcontrib>But, Abdülkadir</creatorcontrib><creatorcontrib>Ozcan, Cemal</creatorcontrib><title>The role of oxidative stress in postoperative delirium</title><title>General hospital psychiatry</title><addtitle>Gen Hosp Psychiatry</addtitle><description>This study aimed to determine a marker that predicts delirium using preoperative oxidative processes in patients undergoing cardiopulmonary bypass surgery.
Twelve of the 50 patients included in the study showed signs of delirium during postoperative follow-up. The Delirium Rating Scale was used in patients with delirium according to
DSM-IV-TR in the postoperative period. Venous blood samples were obtained from the patients the day before and the day after the surgery to determine plasma antioxidant enzyme levels.
While there were no differences in preoperative superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) levels in both groups, catalase (CAT) levels were significantly lower in the delirium group. Postoperative SOD and MDA levels were also higher in the delirium group, while the GSH-Px levels were found to be lower when compared with those during the preoperative period. In the nondelirium group, the postoperative MDA and GSH-Px levels were found to be lower than preoperative levels, and postoperative SOD levels were found to be higher than preoperative levels. CAT levels were lower in the delirium group when the pre- and postoperative levels were compared in both groups. The postoperative levels of SOD, GSH-Px and CAT in the nondelirium group and MDA in the delirium group were significantly higher than preoperative levels.
Patients with low preoperative CAT levels appeared to be more susceptible to delirium than patients with higher CAT levels.</description><subject>Adult and adolescent clinical studies</subject><subject>Aged</subject><subject>Antioxidant enzymes</subject><subject>Antioxidants - physiology</subject><subject>Biological and medical sciences</subject><subject>Brain - physiopathology</subject><subject>Cardiopulmonary Bypass - adverse effects</subject><subject>Cardiopulmonary bypass surgery</subject><subject>Catalase - blood</subject><subject>Coronary Disease - surgery</subject><subject>Delirium</subject><subject>Delirium - diagnosis</subject><subject>Delirium - physiopathology</subject><subject>Delirium - psychology</subject><subject>Female</subject><subject>Free radicals</subject><subject>Free Radicals - blood</subject><subject>Glutathione Peroxidase - blood</subject><subject>Humans</subject><subject>Lipid Peroxidation - physiology</subject><subject>Male</subject><subject>Malondialdehyde - blood</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurons - physiology</subject><subject>Organic mental disorders. Neuropsychology</subject><subject>Oxidative Stress - physiology</subject><subject>Postoperative Complications - diagnosis</subject><subject>Postoperative Complications - physiopathology</subject><subject>Postoperative Complications - psychology</subject><subject>Predictive Value of Tests</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Risk Factors</subject><subject>Superoxide Dismutase - blood</subject><issn>0163-8343</issn><issn>1873-7714</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMFq3DAQhkVpaTZpXyGYQnvzdmTJktxbSJu0EOglPQtZGnW1eC1H4w3N29fLLiTHwMDA8M3Mz8fYJw5rDlx93a7_4rjJNE305DfrBkCtDwXNG7biRotaay7fstUCi9oIKc7YOdEWANqmFe_ZGVddC0KbFVP3G6xKHrDKscr_UnBzesSK5oJEVRqrKdOcJyzHecAhlbTffWDvohsIP576Bftz8-P--md99_v21_XVXe0lmLl2TomIHkE4xSW02vG-bToNrjEygFZ9FKaJoHovQ-z6JR_nQfed9hBaFcUF-3K8O5X8sEea7S6Rx2FwI-Y9WWUMbzvJF_DbEfQlExWMdipp58qT5WAP1uzWvrRmD9bsoaBZli9PX_b9DsPz6knTAnw-AY68G2Jxo0_0zBkpNQdYuO9HDhcnjwmLJZ9w9BhSQT_bkNNr8vwH1lCR_A</recordid><startdate>20060901</startdate><enddate>20060901</enddate><creator>Karlidag, Rifat</creator><creator>Unal, Suheyla</creator><creator>Sezer, Ozlem H.</creator><creator>Bay Karabulut, Aysun</creator><creator>Battaloğlu, Bektaş</creator><creator>But, Abdülkadir</creator><creator>Ozcan, Cemal</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060901</creationdate><title>The role of oxidative stress in postoperative delirium</title><author>Karlidag, Rifat ; Unal, Suheyla ; Sezer, Ozlem H. ; Bay Karabulut, Aysun ; Battaloğlu, Bektaş ; But, Abdülkadir ; Ozcan, Cemal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-aa63fece03a614057a1b52970a284d076bf382f06bc4df9b05211d7b97c0d56f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Aged</topic><topic>Antioxidant enzymes</topic><topic>Antioxidants - physiology</topic><topic>Biological and medical sciences</topic><topic>Brain - physiopathology</topic><topic>Cardiopulmonary Bypass - adverse effects</topic><topic>Cardiopulmonary bypass surgery</topic><topic>Catalase - blood</topic><topic>Coronary Disease - surgery</topic><topic>Delirium</topic><topic>Delirium - diagnosis</topic><topic>Delirium - physiopathology</topic><topic>Delirium - psychology</topic><topic>Female</topic><topic>Free radicals</topic><topic>Free Radicals - blood</topic><topic>Glutathione Peroxidase - blood</topic><topic>Humans</topic><topic>Lipid Peroxidation - physiology</topic><topic>Male</topic><topic>Malondialdehyde - blood</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurons - physiology</topic><topic>Organic mental disorders. Neuropsychology</topic><topic>Oxidative Stress - physiology</topic><topic>Postoperative Complications - diagnosis</topic><topic>Postoperative Complications - physiopathology</topic><topic>Postoperative Complications - psychology</topic><topic>Predictive Value of Tests</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Risk Factors</topic><topic>Superoxide Dismutase - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karlidag, Rifat</creatorcontrib><creatorcontrib>Unal, Suheyla</creatorcontrib><creatorcontrib>Sezer, Ozlem H.</creatorcontrib><creatorcontrib>Bay Karabulut, Aysun</creatorcontrib><creatorcontrib>Battaloğlu, Bektaş</creatorcontrib><creatorcontrib>But, Abdülkadir</creatorcontrib><creatorcontrib>Ozcan, Cemal</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>General hospital psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karlidag, Rifat</au><au>Unal, Suheyla</au><au>Sezer, Ozlem H.</au><au>Bay Karabulut, Aysun</au><au>Battaloğlu, Bektaş</au><au>But, Abdülkadir</au><au>Ozcan, Cemal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of oxidative stress in postoperative delirium</atitle><jtitle>General hospital psychiatry</jtitle><addtitle>Gen Hosp Psychiatry</addtitle><date>2006-09-01</date><risdate>2006</risdate><volume>28</volume><issue>5</issue><spage>418</spage><epage>423</epage><pages>418-423</pages><issn>0163-8343</issn><eissn>1873-7714</eissn><coden>GHPSDB</coden><abstract>This study aimed to determine a marker that predicts delirium using preoperative oxidative processes in patients undergoing cardiopulmonary bypass surgery.
Twelve of the 50 patients included in the study showed signs of delirium during postoperative follow-up. The Delirium Rating Scale was used in patients with delirium according to
DSM-IV-TR in the postoperative period. Venous blood samples were obtained from the patients the day before and the day after the surgery to determine plasma antioxidant enzyme levels.
While there were no differences in preoperative superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) levels in both groups, catalase (CAT) levels were significantly lower in the delirium group. Postoperative SOD and MDA levels were also higher in the delirium group, while the GSH-Px levels were found to be lower when compared with those during the preoperative period. In the nondelirium group, the postoperative MDA and GSH-Px levels were found to be lower than preoperative levels, and postoperative SOD levels were found to be higher than preoperative levels. CAT levels were lower in the delirium group when the pre- and postoperative levels were compared in both groups. The postoperative levels of SOD, GSH-Px and CAT in the nondelirium group and MDA in the delirium group were significantly higher than preoperative levels.
Patients with low preoperative CAT levels appeared to be more susceptible to delirium than patients with higher CAT levels.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>16950378</pmid><doi>10.1016/j.genhosppsych.2006.06.002</doi><tpages>6</tpages></addata></record> |
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| ispartof | General hospital psychiatry, 2006-09, Vol.28 (5), p.418-423 |
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| subjects | Adult and adolescent clinical studies Aged Antioxidant enzymes Antioxidants - physiology Biological and medical sciences Brain - physiopathology Cardiopulmonary Bypass - adverse effects Cardiopulmonary bypass surgery Catalase - blood Coronary Disease - surgery Delirium Delirium - diagnosis Delirium - physiopathology Delirium - psychology Female Free radicals Free Radicals - blood Glutathione Peroxidase - blood Humans Lipid Peroxidation - physiology Male Malondialdehyde - blood Medical sciences Middle Aged Neurons - physiology Organic mental disorders. Neuropsychology Oxidative Stress - physiology Postoperative Complications - diagnosis Postoperative Complications - physiopathology Postoperative Complications - psychology Predictive Value of Tests Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Risk Factors Superoxide Dismutase - blood |
| title | The role of oxidative stress in postoperative delirium |
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