Memory Impairment in Obese Zucker Rats: An Investigation of Cognitive Function in an Animal Model of Insulin Resistance and Obesity
The genetically obese Zucker rat is a widely investigated model of pathological changes associated with type 2 diabetes. To assess cognitive function, obese and lean Zucker rats were tested on a variable-interval delayed alternation test of learning and memory. There were no group differences in lea...
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| Veröffentlicht in: | Behavioral neuroscience 2005-10, Vol.119 (5), p.1389-1395 |
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| container_title | Behavioral neuroscience |
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| creator | Winocur, Gordon Greenwood, Carol E Piroli, Gerardo G Grillo, Claudia A Reagan, Lawrence P McEwen, Bruce S Reznikov, Leah R |
| description | The genetically obese Zucker rat is a widely investigated model of pathological changes associated with type 2 diabetes. To assess cognitive function, obese and lean Zucker rats were tested on a variable-interval delayed alternation test of learning and memory. There were no group differences in learning the alternation rule or at short intervals, but obese rats were impaired at longer intervals where performance is hippocampus dependent. Plasma membrane association of the insulin sensitive glucose transporter, GLUT4, was reduced in the hippocampus of obese rats in the absence of changes in total GLUT4 and insulin receptor expression. These results parallel those of human studies in pointing to the susceptibility of the hippocampus and related structures to the adverse environment of diabetes mellitus. |
| doi_str_mv | 10.1037/0735-7044.119.5.1389 |
| format | Article |
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To assess cognitive function, obese and lean Zucker rats were tested on a variable-interval delayed alternation test of learning and memory. There were no group differences in learning the alternation rule or at short intervals, but obese rats were impaired at longer intervals where performance is hippocampus dependent. Plasma membrane association of the insulin sensitive glucose transporter, GLUT4, was reduced in the hippocampus of obese rats in the absence of changes in total GLUT4 and insulin receptor expression. These results parallel those of human studies in pointing to the susceptibility of the hippocampus and related structures to the adverse environment of diabetes mellitus.</description><identifier>ISSN: 0735-7044</identifier><identifier>EISSN: 1939-0084</identifier><identifier>DOI: 10.1037/0735-7044.119.5.1389</identifier><identifier>PMID: 16300445</identifier><identifier>CODEN: BENEDJ</identifier><language>eng</language><publisher>Washington, DC: American Psychological Association</publisher><subject>Analysis of Variance ; Animal ; Animal Learning ; Animal Models ; Animals ; Behavior, Animal ; Biological and medical sciences ; Blood Glucose ; Blotting, Western - methods ; Cell Membrane - metabolism ; Choice Behavior - physiology ; Cognition & reasoning ; Cognition - physiology ; Cognitive Ability ; Cognitive Impairment ; Diabetes ; Diabetes Mellitus, Type 2 - metabolism ; Diabetes Mellitus, Type 2 - physiopathology ; Disease Models, Animal ; Fundamental and applied biological sciences. Psychology ; Insulin ; Insulin Resistance - physiology ; Learning. Memory ; Memory ; Memory Disorders - metabolism ; Memory Disorders - physiopathology ; Obesity ; Obesity - physiopathology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Psychomotor Performance ; Rats ; Rats, Zucker ; Receptor, Insulin - metabolism ; Receptors, AMPA - metabolism ; Reinforcement Schedule ; Rodents ; Time Factors ; Type 2 Diabetes</subject><ispartof>Behavioral neuroscience, 2005-10, Vol.119 (5), p.1389-1395</ispartof><rights>2005 American Psychological Association</rights><rights>2006 INIST-CNRS</rights><rights>Copyright American Psychological Association Oct 2005</rights><rights>2005, American Psychological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a489t-6ad9347d41dfe63629064cec76612893e68a12f5f0b6f36e8da90256b4e3d6513</citedby><cites>FETCH-LOGICAL-a489t-6ad9347d41dfe63629064cec76612893e68a12f5f0b6f36e8da90256b4e3d6513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17277602$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16300445$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Disterhoft, John F</contributor><creatorcontrib>Winocur, Gordon</creatorcontrib><creatorcontrib>Greenwood, Carol E</creatorcontrib><creatorcontrib>Piroli, Gerardo G</creatorcontrib><creatorcontrib>Grillo, Claudia A</creatorcontrib><creatorcontrib>Reagan, Lawrence P</creatorcontrib><creatorcontrib>McEwen, Bruce S</creatorcontrib><creatorcontrib>Reznikov, Leah R</creatorcontrib><title>Memory Impairment in Obese Zucker Rats: An Investigation of Cognitive Function in an Animal Model of Insulin Resistance and Obesity</title><title>Behavioral neuroscience</title><addtitle>Behav Neurosci</addtitle><description>The genetically obese Zucker rat is a widely investigated model of pathological changes associated with type 2 diabetes. To assess cognitive function, obese and lean Zucker rats were tested on a variable-interval delayed alternation test of learning and memory. There were no group differences in learning the alternation rule or at short intervals, but obese rats were impaired at longer intervals where performance is hippocampus dependent. Plasma membrane association of the insulin sensitive glucose transporter, GLUT4, was reduced in the hippocampus of obese rats in the absence of changes in total GLUT4 and insulin receptor expression. These results parallel those of human studies in pointing to the susceptibility of the hippocampus and related structures to the adverse environment of diabetes mellitus.</description><subject>Analysis of Variance</subject><subject>Animal</subject><subject>Animal Learning</subject><subject>Animal Models</subject><subject>Animals</subject><subject>Behavior, Animal</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose</subject><subject>Blotting, Western - methods</subject><subject>Cell Membrane - metabolism</subject><subject>Choice Behavior - physiology</subject><subject>Cognition & reasoning</subject><subject>Cognition - physiology</subject><subject>Cognitive Ability</subject><subject>Cognitive Impairment</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Disease Models, Animal</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Insulin</subject><subject>Insulin Resistance - physiology</subject><subject>Learning. Memory</subject><subject>Memory</subject><subject>Memory Disorders - metabolism</subject><subject>Memory Disorders - physiopathology</subject><subject>Obesity</subject><subject>Obesity - physiopathology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Psychomotor Performance</subject><subject>Rats</subject><subject>Rats, Zucker</subject><subject>Receptor, Insulin - metabolism</subject><subject>Receptors, AMPA - metabolism</subject><subject>Reinforcement Schedule</subject><subject>Rodents</subject><subject>Time Factors</subject><subject>Type 2 Diabetes</subject><issn>0735-7044</issn><issn>1939-0084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U2LFDEQBuAgijuu_gORRnBuPVY6SSU5yuLHwsqC6MVLSKerodf-Muk-zL83zQwuLqKn5PBUJVUvYy85HDgI_Ra0UKUGKQ-c24M6cGHsI7bjVtgSwMjHbPebXLBnKd0BgASpnrILjiLfpdqx_WcapngsrofZd3GgcSm6sbitKVHxfQ0_KBZf_JKesyet7xO9OJ-X7NuH91-vPpU3tx-vr97dlF4au5ToGyukbiRvWkKBlQWUgYJG5JWxgtB4XrWqhRpbgWQab6FSWEsSDSouLtn-1HeO08-V0uKGLgXqez_StCaHxnAFWP0XcisNt0pm-PoBvJvWOOYhHHIphVay-heqIO_VGLQZyRMKcUopUuvm2A0-Hh0Ht0Xitn27bd8uR-KU2yLJZa_Ovdd6oOa-6JxBBm_OwKfg-zb6MXTp3ulKa4Ttk-XJ-dm7OR2Dj0sXekphjTEH5-qR_nx4_3f_EP4CJS-sKA</recordid><startdate>20051001</startdate><enddate>20051001</enddate><creator>Winocur, Gordon</creator><creator>Greenwood, Carol E</creator><creator>Piroli, Gerardo G</creator><creator>Grillo, Claudia A</creator><creator>Reagan, Lawrence P</creator><creator>McEwen, Bruce S</creator><creator>Reznikov, Leah R</creator><general>American Psychological Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7RZ</scope><scope>PSYQQ</scope><scope>7X8</scope></search><sort><creationdate>20051001</creationdate><title>Memory Impairment in Obese Zucker Rats</title><author>Winocur, Gordon ; Greenwood, Carol E ; Piroli, Gerardo G ; Grillo, Claudia A ; Reagan, Lawrence P ; McEwen, Bruce S ; Reznikov, Leah R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a489t-6ad9347d41dfe63629064cec76612893e68a12f5f0b6f36e8da90256b4e3d6513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Analysis of Variance</topic><topic>Animal</topic><topic>Animal Learning</topic><topic>Animal Models</topic><topic>Animals</topic><topic>Behavior, Animal</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose</topic><topic>Blotting, Western - methods</topic><topic>Cell Membrane - metabolism</topic><topic>Choice Behavior - physiology</topic><topic>Cognition & reasoning</topic><topic>Cognition - physiology</topic><topic>Cognitive Ability</topic><topic>Cognitive Impairment</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Disease Models, Animal</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Insulin</topic><topic>Insulin Resistance - physiology</topic><topic>Learning. Memory</topic><topic>Memory</topic><topic>Memory Disorders - metabolism</topic><topic>Memory Disorders - physiopathology</topic><topic>Obesity</topic><topic>Obesity - physiopathology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Psychomotor Performance</topic><topic>Rats</topic><topic>Rats, Zucker</topic><topic>Receptor, Insulin - metabolism</topic><topic>Receptors, AMPA - metabolism</topic><topic>Reinforcement Schedule</topic><topic>Rodents</topic><topic>Time Factors</topic><topic>Type 2 Diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Winocur, Gordon</creatorcontrib><creatorcontrib>Greenwood, Carol E</creatorcontrib><creatorcontrib>Piroli, Gerardo G</creatorcontrib><creatorcontrib>Grillo, Claudia A</creatorcontrib><creatorcontrib>Reagan, Lawrence P</creatorcontrib><creatorcontrib>McEwen, Bruce S</creatorcontrib><creatorcontrib>Reznikov, Leah R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>APA PsycArticles®</collection><collection>ProQuest One Psychology</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioral neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Winocur, Gordon</au><au>Greenwood, Carol E</au><au>Piroli, Gerardo G</au><au>Grillo, Claudia A</au><au>Reagan, Lawrence P</au><au>McEwen, Bruce S</au><au>Reznikov, Leah R</au><au>Disterhoft, John F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Memory Impairment in Obese Zucker Rats: An Investigation of Cognitive Function in an Animal Model of Insulin Resistance and Obesity</atitle><jtitle>Behavioral neuroscience</jtitle><addtitle>Behav Neurosci</addtitle><date>2005-10-01</date><risdate>2005</risdate><volume>119</volume><issue>5</issue><spage>1389</spage><epage>1395</epage><pages>1389-1395</pages><issn>0735-7044</issn><eissn>1939-0084</eissn><coden>BENEDJ</coden><abstract>The genetically obese Zucker rat is a widely investigated model of pathological changes associated with type 2 diabetes. To assess cognitive function, obese and lean Zucker rats were tested on a variable-interval delayed alternation test of learning and memory. There were no group differences in learning the alternation rule or at short intervals, but obese rats were impaired at longer intervals where performance is hippocampus dependent. Plasma membrane association of the insulin sensitive glucose transporter, GLUT4, was reduced in the hippocampus of obese rats in the absence of changes in total GLUT4 and insulin receptor expression. These results parallel those of human studies in pointing to the susceptibility of the hippocampus and related structures to the adverse environment of diabetes mellitus.</abstract><cop>Washington, DC</cop><pub>American Psychological Association</pub><pmid>16300445</pmid><doi>10.1037/0735-7044.119.5.1389</doi><tpages>7</tpages></addata></record> |
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| subjects | Analysis of Variance Animal Animal Learning Animal Models Animals Behavior, Animal Biological and medical sciences Blood Glucose Blotting, Western - methods Cell Membrane - metabolism Choice Behavior - physiology Cognition & reasoning Cognition - physiology Cognitive Ability Cognitive Impairment Diabetes Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - physiopathology Disease Models, Animal Fundamental and applied biological sciences. Psychology Insulin Insulin Resistance - physiology Learning. Memory Memory Memory Disorders - metabolism Memory Disorders - physiopathology Obesity Obesity - physiopathology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychomotor Performance Rats Rats, Zucker Receptor, Insulin - metabolism Receptors, AMPA - metabolism Reinforcement Schedule Rodents Time Factors Type 2 Diabetes |
| title | Memory Impairment in Obese Zucker Rats: An Investigation of Cognitive Function in an Animal Model of Insulin Resistance and Obesity |
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