Specific adducts recognised by a monoclonal antibody against cisplatin-modified DNA

Numerous clinical or experimental studies have employed monoclonal antibody CP9/19 for quantification of cisplatin DNA adducts. The nature of adducts recognised by CP9/19 on polymeric DNA were defined using synthetic deoxynucleotides reacted with cisplatin. Total adduct levels were determined by ato...

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Veröffentlicht in:	Biochemical pharmacology 2005-12, Vol.70 (12), p.1717-1725
Hauptverfasser:	Meczes, Emma L., Azim-Araghi, Ali, Ottley, Christopher J., Pearson, D. Graham, Tilby, Michael J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - immunology Antineoplastic agents Biological and medical sciences Chromatography, Ion Exchange Cisplatin Cisplatin - metabolism DNA adduct DNA Adducts - analysis DNA Adducts - immunology Enzyme-Linked Immunosorbent Assay General aspects Humans ICP-MS Immunoassay Ion-exchange chromatography Medical sciences Oligodeoxyribonucleotides - immunology Oligonucleotide Pharmacology. Drug treatments
Online-Zugang:	Volltext
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