Site-specific accumulation of the cancer preventive dietary polyphenol ellagic acid in epithelial cells of the aerodigestive tract

Ellagic acid (EA), a polyphenol present in berries, has been demonstrated to prevent oesophageal and colon cancer in animals. To better understand the site‐specificity of these effects, we studied the accumulation and transport of [14C]EA in rat aerodigestive epithelial cells in‐vivo and in cultured...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2006-09, Vol.58 (9), p.1201-1209
Hauptverfasser:	Whitley, Alexander C., Sweet, Douglas H., Walle, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid - pharmacology Animals Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - blood Antineoplastic Agents, Phytogenic - pharmacokinetics Caco-2 Cells Colon - cytology Colon - drug effects Colon - metabolism Ellagic Acid - administration & dosage Ellagic Acid - blood Ellagic Acid - pharmacokinetics Epithelial Cells - chemistry Epithelial Cells - drug effects Epithelial Cells - metabolism Esophagus - cytology Esophagus - drug effects Esophagus - metabolism Gastrointestinal Tract - cytology Gastrointestinal Tract - metabolism Humans Hydrogen-Ion Concentration Injections, Intravenous Intestine, Small - cytology Intestine, Small - drug effects Intestine, Small - metabolism Intubation, Gastrointestinal Male Organic Anion Transport Protein 1 - antagonists & inhibitors Organic Anion Transport Protein 1 - genetics Organic Anion Transport Protein 1 - metabolism Organic Anion Transporters, Sodium-Independent - antagonists & inhibitors Organic Anion Transporters, Sodium-Independent - genetics Organic Anion Transporters, Sodium-Independent - metabolism Rats Rats, Inbred F344 RNA, Messenger - analysis Sulfobromophthalein - pharmacology Tissue Distribution
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