The involvement of non-B DNA structures in gross chromosomal rearrangements

Non-B DNA conformations adopted by certain types of DNA sequences promote genetic instabilities, especially gross rearrangements including translocations. We conclude the following: (a) slipped (hairpin) structures, cruciforms, triplexes, tetraplexes and i-motifs, and left-handed Z-DNA are formed in...

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Veröffentlicht in:	DNA repair 2006-09, Vol.5 (9), p.1161-1170
Hauptverfasser:	Bacolla, Albino, Wojciechowska, Marzena, Kosmider, Beata, Larson, Jacquelynn E., Wells, Robert D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Chromosome Aberrations Chromosome Deletion DNA - chemistry Genetic Diseases, Inborn - genetics Genomic Instability Gross deletions Hereditary diseases Humans Low copy repeats (LCRs) Models, Genetic Molecular Conformation Molecular Sequence Data Myotonic Dystrophy - genetics Non-B DNA conformations Syndrome Translocation, Genetic Triplet and tetranucleotide repeats
Online-Zugang:	Volltext
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