Involvement of Bcl-2 family, cytochrome c and caspase 3 in induction of apoptosis by beauvericin in human non-small cell lung cancer cells

Beauvericin (BEA), a cyclic hexadepsipeptide from Codyceps cicadae, possesses anti-convulsion, anti-arrhythmia, sedation, and anti-tumor activities. It has been reported that BEA induces apoptosis in several cancer cell lines. However, the molecular mechanism underlying the BEA-induced apoptotic pro...

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Veröffentlicht in:	Cancer letters 2005-12, Vol.230 (2), p.248-259
Hauptverfasser:	Lin, Hen-I., Lee, Yih-Jing, Chen, Bing-Fang, Tsai, Meng-Chao, Lu, Jen-Lin, Chou, Cheng-Jen, Jow, Guey-Mei
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis Bcl-2 Beauvericin Cancer therapies Carcinoma, Non-Small-Cell Lung Caspase 3 Caspases - metabolism Cell Line, Tumor Cell Survival - drug effects Chemicals Cytochrome c Cytochromes c - metabolism Cytotoxicity Depsipeptides - pharmacology DNA Fragmentation Humans In Situ Nick-End Labeling Lung cancer Lung Neoplasms Membrane Potentials - drug effects Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitochondria - physiology Permeability Proteins Proto-Oncogene Proteins c-bcl-2 - metabolism Studies
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