The PDZ/coiled-coil domain containing protein PIST modulates insulin secretion in MIN6 insulinoma cells by interacting with somatostatin receptor subtype 5

The multi-domain protein PIST (protein interacting specifically with Tc10) interacts with the SSTR5 (somatostatin receptor 5) and is responsible for its intracellular localization. Here, we show that PIST is expressed in pancreatic β-cells and interacts with SSTR5 in these cells. PIST expression in...

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Veröffentlicht in:	FEBS letters 2005-11, Vol.579 (28), p.6305-6310
Hauptverfasser:	Wente, Wolf, Efanov, Alexander M., Treinies, Iris, Zitzer, Heike, Gromada, Jesper, Richter, Dietmar, Kreienkamp, Hans-Jürgen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins - analysis Carrier Proteins - genetics Carrier Proteins - metabolism Cell Membrane - chemistry Cell Membrane - metabolism CFTR cystic fibrosis transmembrane regulator EGFP enhanced green fluorescent protein G-protein coupled receptor Glucose - pharmacology glutathione S-transferase GPCR GST hGH human growth hormone Humans Insulin - metabolism Insulin Secretion Insulin-Secreting Cells - chemistry Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Insulinoma Islets Membrane Proteins - analysis Membrane Proteins - genetics Membrane Proteins - metabolism Mice PDZ PIST protein interacting specifically with Tc10 Protein Structure, Tertiary PSD-95/discs large/zonula occludens 1 Rats Rats, Wistar Receptors, Somatostatin - agonists Receptors, Somatostatin - analysis Receptors, Somatostatin - metabolism somatostatin Somatostatin - pharmacology somatostatin receptor 5 Somatostatin subtype 5 receptor SST SSTR5
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