Antipanic efficacy of paroxetine and polymorphism within the promoter of the serotonin transporter gene

Serotonin selective reuptake inhibitors (SSRIs) are the drugs of choice in the treatment of panic disorder (PD). The serotonin transporter (5-HTT) is a prime target for SSRIs. A functional polymorphism within the promoter region of the 5-HTT gene, leading to different transcriptional efficiency, was...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2005-12, Vol.30 (12), p.2230-2235
Hauptverfasser:	PERNA, Giampaolo, FAVARON, Elisa, DI BELLA, Daniela, BUSSI, Riccardo, BELLODI, Laura
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alleles Antidepressive Agents, Second-Generation - therapeutic use Biological and medical sciences Drugs Fear - psychology Female Gene Frequency Genotype Humans Male Medical sciences Panic attacks Panic Disorder - drug therapy Panic Disorder - genetics Panic Disorder - psychology Paroxetine - therapeutic use Polymorphism Promoter Regions, Genetic - genetics Psychiatric Status Rating Scales Reverse Transcriptase Polymerase Chain Reaction Serotonin Serotonin Plasma Membrane Transport Proteins - genetics Surveys and Questionnaires
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