Chemopreventive properties of the ethanol extract of chinese licorice ( Glycyrrhiza uralensis) root: induction of apoptosis and G1 cell cycle arrest in MCF-7 human breast cancer cells
Much of the interest on the chemopreventive properties of licorice has been focused on the plant genius Glycyrrhiza glabra. In this study the ethanol extract of Chinese licorice root, Glycyrrhiza uralensis ( G. uralensis) was investigated for its estrogenic effect and the ability to inhibit cell pro...
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| Veröffentlicht in: | Cancer letters 2005-12, Vol.230 (2), p.239-247 |
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| creator | Jo, Eun-Hye Kim, Sung-Hoon Ra, Jeong-Chan Kim, Sung-Ran Cho, Sung-Dae Jung, Ji-Won Yang, Se-Ran Park, Joon-Suk Hwang, Jae-Woong Aruoma, Okezie I Kim, Tae-Yung Lee, Yong-Soon Kang, Kyung-Sun |
| description | Much of the interest on the chemopreventive properties of licorice has been focused on the plant genius
Glycyrrhiza glabra. In this study the ethanol extract of Chinese licorice root,
Glycyrrhiza uralensis (
G. uralensis) was investigated for its estrogenic effect and the ability to inhibit cell proliferation in the MCF-7 human breast cancer cell line. The extract of the root of
G. uralensis was fractionated in EtOH:H
2O (80:20) (80% ethanol). The extract exhibited estrogenic effects similar to 17β- estradiol (E2) and induced apoptosis at the same dose level (100
μg/ml) in MCF-7 breast cancer cells, results were associated with up-regulation of tumor suppressor gene p53 and pro-apoptotic protein Bax.
G. uralensis extract caused the up-regulation of p21
waf1/cip1 and down-regulation of cdk 2 and cyclin E and most significantly, induced G1 cell cycle arrest. This is the first study to show that the ethanolic extract of the root of
G. uralensis has an estrogen-like activity and anti-cancer effects against MCF-7 human breast cancer cells. Whilst the use of phytoestrogens to protect against hormone-dependent cancers or as a ‘natural’ alternative to hormone replacement therapy remains controversial, the data in this paper support the suggestion that extracts of root of the Chinese licorice
G. uralensis might be of importance in this debate. |
| doi_str_mv | 10.1016/j.canlet.2004.12.038 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68811450</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0304383505000133</els_id><sourcerecordid>3241574411</sourcerecordid><originalsourceid>FETCH-LOGICAL-c454t-a5ea486ce02b519a678d06d31e9fc62723dba65e1e539ae7bc2b2841d4a39c193</originalsourceid><addsrcrecordid>eNp9kc2KFDEUhYMoTs_oG4gEBBkXVea3fmYhSOO0wogbXYdU6jaVpiopk1Rj-2K-nim7QXDhKnDznZuTcxB6QUlJCa3eHkqj3QipZISIkrKS8OYR2tCmZkXdNuQx2hBORMEbLq_QdYwHQogUtXyKrmjF2rqmZIN-bQeY_BzgCC7ZI-A5-BlCshCx3-M0AIY0aOdHDD9S0CatYzNYBxHwaI0P1gC-xbvxZE4hDPanxkvQI7ho4xscvE932Lp-Mcl6t4r17Ofk8y3Wrsc7ig2MIzYnMwLWIUBMmceft_dFjYdl0g53AXSe5v8aCH_w-Aw92esxwvPLeYO-3X_4uv1YPHzZfdq-fyiMkCIVWoIWTWWAsE7SVld105Oq5xTavalYzXjf6UoCBclbDXVnWMcaQXuheWtoy2_Q6_PenMv3JXtTk42rA-3AL1FVTUOpkCSDr_4BD34JLntTVBLJayaEzJQ4Uyb4GAPs1RzspMNJUaLWWtVBnWtVa62KMpVrzbKXl-VLN0H_V3TpMQPvzgDkLI4WgorGQo6rtwFMUr23_3_hN9C4uA0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1505372445</pqid></control><display><type>article</type><title>Chemopreventive properties of the ethanol extract of chinese licorice ( Glycyrrhiza uralensis) root: induction of apoptosis and G1 cell cycle arrest in MCF-7 human breast cancer cells</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Jo, Eun-Hye ; Kim, Sung-Hoon ; Ra, Jeong-Chan ; Kim, Sung-Ran ; Cho, Sung-Dae ; Jung, Ji-Won ; Yang, Se-Ran ; Park, Joon-Suk ; Hwang, Jae-Woong ; Aruoma, Okezie I ; Kim, Tae-Yung ; Lee, Yong-Soon ; Kang, Kyung-Sun</creator><creatorcontrib>Jo, Eun-Hye ; Kim, Sung-Hoon ; Ra, Jeong-Chan ; Kim, Sung-Ran ; Cho, Sung-Dae ; Jung, Ji-Won ; Yang, Se-Ran ; Park, Joon-Suk ; Hwang, Jae-Woong ; Aruoma, Okezie I ; Kim, Tae-Yung ; Lee, Yong-Soon ; Kang, Kyung-Sun</creatorcontrib><description>Much of the interest on the chemopreventive properties of licorice has been focused on the plant genius
Glycyrrhiza glabra. In this study the ethanol extract of Chinese licorice root,
Glycyrrhiza uralensis (
G. uralensis) was investigated for its estrogenic effect and the ability to inhibit cell proliferation in the MCF-7 human breast cancer cell line. The extract of the root of
G. uralensis was fractionated in EtOH:H
2O (80:20) (80% ethanol). The extract exhibited estrogenic effects similar to 17β- estradiol (E2) and induced apoptosis at the same dose level (100
μg/ml) in MCF-7 breast cancer cells, results were associated with up-regulation of tumor suppressor gene p53 and pro-apoptotic protein Bax.
G. uralensis extract caused the up-regulation of p21
waf1/cip1 and down-regulation of cdk 2 and cyclin E and most significantly, induced G1 cell cycle arrest. This is the first study to show that the ethanolic extract of the root of
G. uralensis has an estrogen-like activity and anti-cancer effects against MCF-7 human breast cancer cells. Whilst the use of phytoestrogens to protect against hormone-dependent cancers or as a ‘natural’ alternative to hormone replacement therapy remains controversial, the data in this paper support the suggestion that extracts of root of the Chinese licorice
G. uralensis might be of importance in this debate.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/j.canlet.2004.12.038</identifier><identifier>PMID: 16297710</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Amino acids ; Anticarcinogenic Agents - pharmacology ; Apoptosis ; Breast cancer ; Breast Neoplasms ; Cell cycle arrest ; Cell growth ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Cell Survival - drug effects ; Chemoprevention ; Chinese licorice root ; Deoxyribonucleic acid ; DNA ; Enzymes ; Estrogens ; Ethanol ; Ethanol - chemistry ; G1 Phase - drug effects ; Glycyrrhiza - chemistry ; Glycyrrhiza uralensis ; Humans ; Mortality ; Phytoestrogens - pharmacology ; Plant Extracts - pharmacology ; Plant Roots - chemistry ; Receptors, Estrogen ; Veterinary medicine ; Yeast</subject><ispartof>Cancer letters, 2005-12, Vol.230 (2), p.239-247</ispartof><rights>2005 Elsevier Ireland Ltd</rights><rights>Copyright Elsevier Limited Dec 18, 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-a5ea486ce02b519a678d06d31e9fc62723dba65e1e539ae7bc2b2841d4a39c193</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.canlet.2004.12.038$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16297710$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jo, Eun-Hye</creatorcontrib><creatorcontrib>Kim, Sung-Hoon</creatorcontrib><creatorcontrib>Ra, Jeong-Chan</creatorcontrib><creatorcontrib>Kim, Sung-Ran</creatorcontrib><creatorcontrib>Cho, Sung-Dae</creatorcontrib><creatorcontrib>Jung, Ji-Won</creatorcontrib><creatorcontrib>Yang, Se-Ran</creatorcontrib><creatorcontrib>Park, Joon-Suk</creatorcontrib><creatorcontrib>Hwang, Jae-Woong</creatorcontrib><creatorcontrib>Aruoma, Okezie I</creatorcontrib><creatorcontrib>Kim, Tae-Yung</creatorcontrib><creatorcontrib>Lee, Yong-Soon</creatorcontrib><creatorcontrib>Kang, Kyung-Sun</creatorcontrib><title>Chemopreventive properties of the ethanol extract of chinese licorice ( Glycyrrhiza uralensis) root: induction of apoptosis and G1 cell cycle arrest in MCF-7 human breast cancer cells</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Much of the interest on the chemopreventive properties of licorice has been focused on the plant genius
Glycyrrhiza glabra. In this study the ethanol extract of Chinese licorice root,
Glycyrrhiza uralensis (
G. uralensis) was investigated for its estrogenic effect and the ability to inhibit cell proliferation in the MCF-7 human breast cancer cell line. The extract of the root of
G. uralensis was fractionated in EtOH:H
2O (80:20) (80% ethanol). The extract exhibited estrogenic effects similar to 17β- estradiol (E2) and induced apoptosis at the same dose level (100
μg/ml) in MCF-7 breast cancer cells, results were associated with up-regulation of tumor suppressor gene p53 and pro-apoptotic protein Bax.
G. uralensis extract caused the up-regulation of p21
waf1/cip1 and down-regulation of cdk 2 and cyclin E and most significantly, induced G1 cell cycle arrest. This is the first study to show that the ethanolic extract of the root of
G. uralensis has an estrogen-like activity and anti-cancer effects against MCF-7 human breast cancer cells. Whilst the use of phytoestrogens to protect against hormone-dependent cancers or as a ‘natural’ alternative to hormone replacement therapy remains controversial, the data in this paper support the suggestion that extracts of root of the Chinese licorice
G. uralensis might be of importance in this debate.</description><subject>Amino acids</subject><subject>Anticarcinogenic Agents - pharmacology</subject><subject>Apoptosis</subject><subject>Breast cancer</subject><subject>Breast Neoplasms</subject><subject>Cell cycle arrest</subject><subject>Cell growth</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Chemoprevention</subject><subject>Chinese licorice root</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Enzymes</subject><subject>Estrogens</subject><subject>Ethanol</subject><subject>Ethanol - chemistry</subject><subject>G1 Phase - drug effects</subject><subject>Glycyrrhiza - chemistry</subject><subject>Glycyrrhiza uralensis</subject><subject>Humans</subject><subject>Mortality</subject><subject>Phytoestrogens - pharmacology</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Roots - chemistry</subject><subject>Receptors, Estrogen</subject><subject>Veterinary medicine</subject><subject>Yeast</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2KFDEUhYMoTs_oG4gEBBkXVea3fmYhSOO0wogbXYdU6jaVpiopk1Rj-2K-nim7QXDhKnDznZuTcxB6QUlJCa3eHkqj3QipZISIkrKS8OYR2tCmZkXdNuQx2hBORMEbLq_QdYwHQogUtXyKrmjF2rqmZIN-bQeY_BzgCC7ZI-A5-BlCshCx3-M0AIY0aOdHDD9S0CatYzNYBxHwaI0P1gC-xbvxZE4hDPanxkvQI7ho4xscvE932Lp-Mcl6t4r17Ofk8y3Wrsc7ig2MIzYnMwLWIUBMmceft_dFjYdl0g53AXSe5v8aCH_w-Aw92esxwvPLeYO-3X_4uv1YPHzZfdq-fyiMkCIVWoIWTWWAsE7SVld105Oq5xTavalYzXjf6UoCBclbDXVnWMcaQXuheWtoy2_Q6_PenMv3JXtTk42rA-3AL1FVTUOpkCSDr_4BD34JLntTVBLJayaEzJQ4Uyb4GAPs1RzspMNJUaLWWtVBnWtVa62KMpVrzbKXl-VLN0H_V3TpMQPvzgDkLI4WgorGQo6rtwFMUr23_3_hN9C4uA0</recordid><startdate>20051218</startdate><enddate>20051218</enddate><creator>Jo, Eun-Hye</creator><creator>Kim, Sung-Hoon</creator><creator>Ra, Jeong-Chan</creator><creator>Kim, Sung-Ran</creator><creator>Cho, Sung-Dae</creator><creator>Jung, Ji-Won</creator><creator>Yang, Se-Ran</creator><creator>Park, Joon-Suk</creator><creator>Hwang, Jae-Woong</creator><creator>Aruoma, Okezie I</creator><creator>Kim, Tae-Yung</creator><creator>Lee, Yong-Soon</creator><creator>Kang, Kyung-Sun</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20051218</creationdate><title>Chemopreventive properties of the ethanol extract of chinese licorice ( Glycyrrhiza uralensis) root: induction of apoptosis and G1 cell cycle arrest in MCF-7 human breast cancer cells</title><author>Jo, Eun-Hye ; Kim, Sung-Hoon ; Ra, Jeong-Chan ; Kim, Sung-Ran ; Cho, Sung-Dae ; Jung, Ji-Won ; Yang, Se-Ran ; Park, Joon-Suk ; Hwang, Jae-Woong ; Aruoma, Okezie I ; Kim, Tae-Yung ; Lee, Yong-Soon ; Kang, Kyung-Sun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-a5ea486ce02b519a678d06d31e9fc62723dba65e1e539ae7bc2b2841d4a39c193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Amino acids</topic><topic>Anticarcinogenic Agents - pharmacology</topic><topic>Apoptosis</topic><topic>Breast cancer</topic><topic>Breast Neoplasms</topic><topic>Cell cycle arrest</topic><topic>Cell growth</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>Chemoprevention</topic><topic>Chinese licorice root</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Enzymes</topic><topic>Estrogens</topic><topic>Ethanol</topic><topic>Ethanol - chemistry</topic><topic>G1 Phase - drug effects</topic><topic>Glycyrrhiza - chemistry</topic><topic>Glycyrrhiza uralensis</topic><topic>Humans</topic><topic>Mortality</topic><topic>Phytoestrogens - pharmacology</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Roots - chemistry</topic><topic>Receptors, Estrogen</topic><topic>Veterinary medicine</topic><topic>Yeast</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jo, Eun-Hye</creatorcontrib><creatorcontrib>Kim, Sung-Hoon</creatorcontrib><creatorcontrib>Ra, Jeong-Chan</creatorcontrib><creatorcontrib>Kim, Sung-Ran</creatorcontrib><creatorcontrib>Cho, Sung-Dae</creatorcontrib><creatorcontrib>Jung, Ji-Won</creatorcontrib><creatorcontrib>Yang, Se-Ran</creatorcontrib><creatorcontrib>Park, Joon-Suk</creatorcontrib><creatorcontrib>Hwang, Jae-Woong</creatorcontrib><creatorcontrib>Aruoma, Okezie I</creatorcontrib><creatorcontrib>Kim, Tae-Yung</creatorcontrib><creatorcontrib>Lee, Yong-Soon</creatorcontrib><creatorcontrib>Kang, Kyung-Sun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jo, Eun-Hye</au><au>Kim, Sung-Hoon</au><au>Ra, Jeong-Chan</au><au>Kim, Sung-Ran</au><au>Cho, Sung-Dae</au><au>Jung, Ji-Won</au><au>Yang, Se-Ran</au><au>Park, Joon-Suk</au><au>Hwang, Jae-Woong</au><au>Aruoma, Okezie I</au><au>Kim, Tae-Yung</au><au>Lee, Yong-Soon</au><au>Kang, Kyung-Sun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemopreventive properties of the ethanol extract of chinese licorice ( Glycyrrhiza uralensis) root: induction of apoptosis and G1 cell cycle arrest in MCF-7 human breast cancer cells</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2005-12-18</date><risdate>2005</risdate><volume>230</volume><issue>2</issue><spage>239</spage><epage>247</epage><pages>239-247</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>Much of the interest on the chemopreventive properties of licorice has been focused on the plant genius
Glycyrrhiza glabra. In this study the ethanol extract of Chinese licorice root,
Glycyrrhiza uralensis (
G. uralensis) was investigated for its estrogenic effect and the ability to inhibit cell proliferation in the MCF-7 human breast cancer cell line. The extract of the root of
G. uralensis was fractionated in EtOH:H
2O (80:20) (80% ethanol). The extract exhibited estrogenic effects similar to 17β- estradiol (E2) and induced apoptosis at the same dose level (100
μg/ml) in MCF-7 breast cancer cells, results were associated with up-regulation of tumor suppressor gene p53 and pro-apoptotic protein Bax.
G. uralensis extract caused the up-regulation of p21
waf1/cip1 and down-regulation of cdk 2 and cyclin E and most significantly, induced G1 cell cycle arrest. This is the first study to show that the ethanolic extract of the root of
G. uralensis has an estrogen-like activity and anti-cancer effects against MCF-7 human breast cancer cells. Whilst the use of phytoestrogens to protect against hormone-dependent cancers or as a ‘natural’ alternative to hormone replacement therapy remains controversial, the data in this paper support the suggestion that extracts of root of the Chinese licorice
G. uralensis might be of importance in this debate.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>16297710</pmid><doi>10.1016/j.canlet.2004.12.038</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 2005-12, Vol.230 (2), p.239-247 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Amino acids Anticarcinogenic Agents - pharmacology Apoptosis Breast cancer Breast Neoplasms Cell cycle arrest Cell growth Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Chemoprevention Chinese licorice root Deoxyribonucleic acid DNA Enzymes Estrogens Ethanol Ethanol - chemistry G1 Phase - drug effects Glycyrrhiza - chemistry Glycyrrhiza uralensis Humans Mortality Phytoestrogens - pharmacology Plant Extracts - pharmacology Plant Roots - chemistry Receptors, Estrogen Veterinary medicine Yeast |
| title | Chemopreventive properties of the ethanol extract of chinese licorice ( Glycyrrhiza uralensis) root: induction of apoptosis and G1 cell cycle arrest in MCF-7 human breast cancer cells |
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