High plasma VEGF relates to low carbohydrate intake in patients with type 2 diabetes
Objective: Vascular endothelial growth factor (VEGF) has been suggested to enhance glucose transport across the blood-brain barrier, thereby increasing brain glucose supply. Increased brain glucose concentration is known to suppress food intake and to decrease body mass via action on hypothalamic re...
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| Veröffentlicht in: | International Journal of Obesity 2006-09, Vol.30 (9), p.1356-1361 |
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| creator | Hubold, C Oltmanns, K.M Schultes, B Jelkmann, W Born, J Fehm, H.L Schweiger, U Peters, A |
| description | Objective: Vascular endothelial growth factor (VEGF) has been suggested to enhance glucose transport across the blood-brain barrier, thereby increasing brain glucose supply. Increased brain glucose concentration is known to suppress food intake and to decrease body mass via action on hypothalamic regulation centers. Based on the crucial role of VEGF on brain glucose supply, we hypothesized that higher VEGF concentrations are associated with lower food intake and body mass in humans. Methods: Intending to investigate subjects with high variance of blood glucose, we examined patients with type 2 diabetes mellitus. Our hypothesis was tested in a population-based cohort of 190 subjects with type 2 diabetes. Plasma VEGF levels in conjunction with other parameters known to modulate food intake were measured and subsequently correlated with food intake patterns at a breakfast buffet as well as with body mass. Results: We found that subjects with higher concentrations of plasma VEGF had 17% less carbohydrate intake (P=0.003) and 4.8% lower body mass (P=0.017) than those with lower VEGF concentrations. Intake of protein and fat did not correlate with VEGF concentrations. These associations of plasma VEGF were confirmed in multiple linear regression analyses controlling for several parameters interacting with food intake. Conclusion: We conclude that high plasma VEGF concentrations are associated with less carbohydrate intake and lower body mass in type 2 diabetes. The role VEGF plays in facilitating glucose access to the brain represents a new aspect of food intake regulation and energy homeostasis, with relevance for diseases with body mass disturbances. |
| doi_str_mv | 10.1038/sj.ijo.0803293 |
| format | Article |
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Increased brain glucose concentration is known to suppress food intake and to decrease body mass via action on hypothalamic regulation centers. Based on the crucial role of VEGF on brain glucose supply, we hypothesized that higher VEGF concentrations are associated with lower food intake and body mass in humans. Methods: Intending to investigate subjects with high variance of blood glucose, we examined patients with type 2 diabetes mellitus. Our hypothesis was tested in a population-based cohort of 190 subjects with type 2 diabetes. Plasma VEGF levels in conjunction with other parameters known to modulate food intake were measured and subsequently correlated with food intake patterns at a breakfast buffet as well as with body mass. Results: We found that subjects with higher concentrations of plasma VEGF had 17% less carbohydrate intake (P=0.003) and 4.8% lower body mass (P=0.017) than those with lower VEGF concentrations. Intake of protein and fat did not correlate with VEGF concentrations. These associations of plasma VEGF were confirmed in multiple linear regression analyses controlling for several parameters interacting with food intake. Conclusion: We conclude that high plasma VEGF concentrations are associated with less carbohydrate intake and lower body mass in type 2 diabetes. The role VEGF plays in facilitating glucose access to the brain represents a new aspect of food intake regulation and energy homeostasis, with relevance for diseases with body mass disturbances.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/sj.ijo.0803293</identifier><identifier>PMID: 16534523</identifier><identifier>CODEN: IJOBDP</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Analysis of Variance ; Biological and medical sciences ; blood chemistry ; blood glucose ; blood-brain barrier ; Body mass ; Body mass index ; Carbohydrates ; cohort studies ; Cross-Sectional Studies ; Diabetes ; Diabetes Mellitus, Type 2 - blood ; Diabetes. Impaired glucose tolerance ; Diet, Carbohydrate-Restricted ; Eating behavior ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Enzymes ; Epidemiology ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Feeding Behavior ; Feeding. Feeding behavior ; Female ; Food ; food intake ; Fundamental and applied biological sciences. Psychology ; Glucose ; glucose transporters ; Health Promotion and Disease Prevention ; homeostasis ; Hormones ; human nutrition ; Humans ; Insulin ; Internal Medicine ; low carbohydrate diet ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; men ; Metabolic Diseases ; Middle Aged ; noninsulin-dependent diabetes mellitus ; Obesity ; obesity-related diseases ; original-article ; patients ; Permeability ; Plasma ; Proteins ; Public Health ; satiety ; Vascular endothelial growth factor ; Vascular Endothelial Growth Factor A - blood ; vascular endothelial growth factors ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; women</subject><ispartof>International Journal of Obesity, 2006-09, Vol.30 (9), p.1356-1361</ispartof><rights>Springer Nature Limited 2006</rights><rights>2006 INIST-CNRS</rights><rights>COPYRIGHT 2006 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Sep 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c605t-6b03f807f03d3118df069ab4321f9429cab9cb9f57953ee990a0e7dfd93da7cf3</citedby><cites>FETCH-LOGICAL-c605t-6b03f807f03d3118df069ab4321f9429cab9cb9f57953ee990a0e7dfd93da7cf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.ijo.0803293$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.ijo.0803293$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,2725,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18042937$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16534523$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hubold, C</creatorcontrib><creatorcontrib>Oltmanns, K.M</creatorcontrib><creatorcontrib>Schultes, B</creatorcontrib><creatorcontrib>Jelkmann, W</creatorcontrib><creatorcontrib>Born, J</creatorcontrib><creatorcontrib>Fehm, H.L</creatorcontrib><creatorcontrib>Schweiger, U</creatorcontrib><creatorcontrib>Peters, A</creatorcontrib><title>High plasma VEGF relates to low carbohydrate intake in patients with type 2 diabetes</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description>Objective: Vascular endothelial growth factor (VEGF) has been suggested to enhance glucose transport across the blood-brain barrier, thereby increasing brain glucose supply. Increased brain glucose concentration is known to suppress food intake and to decrease body mass via action on hypothalamic regulation centers. Based on the crucial role of VEGF on brain glucose supply, we hypothesized that higher VEGF concentrations are associated with lower food intake and body mass in humans. Methods: Intending to investigate subjects with high variance of blood glucose, we examined patients with type 2 diabetes mellitus. Our hypothesis was tested in a population-based cohort of 190 subjects with type 2 diabetes. Plasma VEGF levels in conjunction with other parameters known to modulate food intake were measured and subsequently correlated with food intake patterns at a breakfast buffet as well as with body mass. Results: We found that subjects with higher concentrations of plasma VEGF had 17% less carbohydrate intake (P=0.003) and 4.8% lower body mass (P=0.017) than those with lower VEGF concentrations. Intake of protein and fat did not correlate with VEGF concentrations. These associations of plasma VEGF were confirmed in multiple linear regression analyses controlling for several parameters interacting with food intake. Conclusion: We conclude that high plasma VEGF concentrations are associated with less carbohydrate intake and lower body mass in type 2 diabetes. The role VEGF plays in facilitating glucose access to the brain represents a new aspect of food intake regulation and energy homeostasis, with relevance for diseases with body mass disturbances.</description><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>blood chemistry</subject><subject>blood glucose</subject><subject>blood-brain barrier</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Carbohydrates</subject><subject>cohort studies</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diet, Carbohydrate-Restricted</subject><subject>Eating behavior</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Enzymes</subject><subject>Epidemiology</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Feeding Behavior</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Food</subject><subject>food intake</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucose</subject><subject>glucose transporters</subject><subject>Health Promotion and Disease Prevention</subject><subject>homeostasis</subject><subject>Hormones</subject><subject>human nutrition</subject><subject>Humans</subject><subject>Insulin</subject><subject>Internal Medicine</subject><subject>low carbohydrate diet</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>men</subject><subject>Metabolic Diseases</subject><subject>Middle Aged</subject><subject>noninsulin-dependent diabetes mellitus</subject><subject>Obesity</subject><subject>obesity-related diseases</subject><subject>original-article</subject><subject>patients</subject><subject>Permeability</subject><subject>Plasma</subject><subject>Proteins</subject><subject>Public Health</subject><subject>satiety</subject><subject>Vascular endothelial growth factor</subject><subject>Vascular Endothelial Growth Factor A - blood</subject><subject>vascular endothelial growth factors</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>women</subject><issn>0307-0565</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkk1vEzEQhlcIREPhyg2wQPSWdLxe79rHquoHUiUOtFytWa-dOGzWqe1VlX-Po0RNQUXIh5E8z_uOZzxF8Z7CjAITp3E5c0s_AwGslOxFMaFVU095JZuXxQQYNFPgNT8q3sS4BADOoXxdHNGas4qXbFLcXrv5gqx7jCskPy-uLkkwPSYTSfKk9w9EY2j9YtOFfEnckPDXNpA1JmeGFMmDSwuSNmtDStI5bE3Wvi1eWeyjebePx8Xd5cXt-fX05vvVt_Ozm6mugadp3QKzAhoLrGOUis5CLbGtWEmtrEqpsZW6lZY3kjNjpAQE03S2k6zDRlt2XJzsfNfB348mJrVyUZu-x8H4MapaCApSNP8FqWSVrIBn8PNf4NKPYchNqJLKMr-Klhn6soPm2BvlButTQL11VGdUiIo1EkSmZs9Q-XRm5bQfjHX5_g_ByRPBwmCfFtH3Y3J-iM866-BjDMaqdXArDBtFQW23QsWlyluh9luRBR_3XY3tynQHfL8GGfi6BzBq7G3AQbt44ATk72DbOZ7uuJhTw9yEw3j-WfrDTjFgGoN5tDzkP-3yFr3CechV736UQBnQbFcLyn4DmwLfWg</recordid><startdate>20060901</startdate><enddate>20060901</enddate><creator>Hubold, C</creator><creator>Oltmanns, K.M</creator><creator>Schultes, B</creator><creator>Jelkmann, W</creator><creator>Born, J</creator><creator>Fehm, H.L</creator><creator>Schweiger, U</creator><creator>Peters, A</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20060901</creationdate><title>High plasma VEGF relates to low carbohydrate intake in patients with type 2 diabetes</title><author>Hubold, C ; Oltmanns, K.M ; Schultes, B ; Jelkmann, W ; Born, J ; Fehm, H.L ; Schweiger, U ; Peters, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c605t-6b03f807f03d3118df069ab4321f9429cab9cb9f57953ee990a0e7dfd93da7cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>blood chemistry</topic><topic>blood glucose</topic><topic>blood-brain barrier</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Carbohydrates</topic><topic>cohort studies</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diet, Carbohydrate-Restricted</topic><topic>Eating behavior</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Enzymes</topic><topic>Epidemiology</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Feeding Behavior</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Food</topic><topic>food intake</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucose</topic><topic>glucose transporters</topic><topic>Health Promotion and Disease Prevention</topic><topic>homeostasis</topic><topic>Hormones</topic><topic>human nutrition</topic><topic>Humans</topic><topic>Insulin</topic><topic>Internal Medicine</topic><topic>low carbohydrate diet</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>men</topic><topic>Metabolic Diseases</topic><topic>Middle Aged</topic><topic>noninsulin-dependent diabetes mellitus</topic><topic>Obesity</topic><topic>obesity-related diseases</topic><topic>original-article</topic><topic>patients</topic><topic>Permeability</topic><topic>Plasma</topic><topic>Proteins</topic><topic>Public Health</topic><topic>satiety</topic><topic>Vascular endothelial growth factor</topic><topic>Vascular Endothelial Growth Factor A - blood</topic><topic>vascular endothelial growth factors</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hubold, C</creatorcontrib><creatorcontrib>Oltmanns, K.M</creatorcontrib><creatorcontrib>Schultes, B</creatorcontrib><creatorcontrib>Jelkmann, W</creatorcontrib><creatorcontrib>Born, J</creatorcontrib><creatorcontrib>Fehm, H.L</creatorcontrib><creatorcontrib>Schweiger, U</creatorcontrib><creatorcontrib>Peters, A</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hubold, C</au><au>Oltmanns, K.M</au><au>Schultes, B</au><au>Jelkmann, W</au><au>Born, J</au><au>Fehm, H.L</au><au>Schweiger, U</au><au>Peters, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High plasma VEGF relates to low carbohydrate intake in patients with type 2 diabetes</atitle><jtitle>International Journal of Obesity</jtitle><stitle>Int J Obes</stitle><addtitle>Int J Obes (Lond)</addtitle><date>2006-09-01</date><risdate>2006</risdate><volume>30</volume><issue>9</issue><spage>1356</spage><epage>1361</epage><pages>1356-1361</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><coden>IJOBDP</coden><abstract>Objective: Vascular endothelial growth factor (VEGF) has been suggested to enhance glucose transport across the blood-brain barrier, thereby increasing brain glucose supply. Increased brain glucose concentration is known to suppress food intake and to decrease body mass via action on hypothalamic regulation centers. Based on the crucial role of VEGF on brain glucose supply, we hypothesized that higher VEGF concentrations are associated with lower food intake and body mass in humans. Methods: Intending to investigate subjects with high variance of blood glucose, we examined patients with type 2 diabetes mellitus. Our hypothesis was tested in a population-based cohort of 190 subjects with type 2 diabetes. Plasma VEGF levels in conjunction with other parameters known to modulate food intake were measured and subsequently correlated with food intake patterns at a breakfast buffet as well as with body mass. Results: We found that subjects with higher concentrations of plasma VEGF had 17% less carbohydrate intake (P=0.003) and 4.8% lower body mass (P=0.017) than those with lower VEGF concentrations. Intake of protein and fat did not correlate with VEGF concentrations. These associations of plasma VEGF were confirmed in multiple linear regression analyses controlling for several parameters interacting with food intake. Conclusion: We conclude that high plasma VEGF concentrations are associated with less carbohydrate intake and lower body mass in type 2 diabetes. The role VEGF plays in facilitating glucose access to the brain represents a new aspect of food intake regulation and energy homeostasis, with relevance for diseases with body mass disturbances.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>16534523</pmid><doi>10.1038/sj.ijo.0803293</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis of Variance Biological and medical sciences blood chemistry blood glucose blood-brain barrier Body mass Body mass index Carbohydrates cohort studies Cross-Sectional Studies Diabetes Diabetes Mellitus, Type 2 - blood Diabetes. Impaired glucose tolerance Diet, Carbohydrate-Restricted Eating behavior Endocrine pancreas. Apud cells (diseases) Endocrinopathies Enzymes Epidemiology Etiopathogenesis. Screening. Investigations. Target tissue resistance Feeding Behavior Feeding. Feeding behavior Female Food food intake Fundamental and applied biological sciences. Psychology Glucose glucose transporters Health Promotion and Disease Prevention homeostasis Hormones human nutrition Humans Insulin Internal Medicine low carbohydrate diet Male Medical sciences Medicine Medicine & Public Health men Metabolic Diseases Middle Aged noninsulin-dependent diabetes mellitus Obesity obesity-related diseases original-article patients Permeability Plasma Proteins Public Health satiety Vascular endothelial growth factor Vascular Endothelial Growth Factor A - blood vascular endothelial growth factors Vertebrates: anatomy and physiology, studies on body, several organs or systems women |
| title | High plasma VEGF relates to low carbohydrate intake in patients with type 2 diabetes |
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