Beneficial effects of aminoguanidine on peritoneal microcirculation and tissue remodelling in a rat model of PD
Background. The formation of glucose degradation products (GDPs) and accumulation of advanced glycation end products (AGEs) partly contribute to the bioincompatibility of peritoneal dialysis fluids (PDF). Aminoguanidine (AG) scavenges GDPs and prevents the formation of AGEs. Methods. In a peritoneal...
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| creator | Zareie, Mohammad Tangelder, Geert-Jan ter Wee, Piet M. Hekking, Liesbeth HP van Lambalgen, Anton A. Keuning, Eelco D. Schadee-Eestermans, Inge L. Schalkwijk, Casper G. Beelen, Robert HJ van den Born, Jacob |
| description | Background. The formation of glucose degradation products (GDPs) and accumulation of advanced glycation end products (AGEs) partly contribute to the bioincompatibility of peritoneal dialysis fluids (PDF). Aminoguanidine (AG) scavenges GDPs and prevents the formation of AGEs. Methods. In a peritoneal dialysis (PD) rat model, we evaluated the effects of the addition of AG to the PDF on microcirculation and morphology of the peritoneum, by intravital microscopy and quantitative morphometric analysis. Results. AG-bicarbonate effectively scavenged different GDPs from PDF. Daily exposure to PDF for 5 weeks resulted in a significant increase in leucocyte rolling in mesenteric venules, which could be reduced for ∼50% by addition of AG-bicarbonate (P |
| doi_str_mv | 10.1093/ndt/gfi138 |
| format | Article |
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The formation of glucose degradation products (GDPs) and accumulation of advanced glycation end products (AGEs) partly contribute to the bioincompatibility of peritoneal dialysis fluids (PDF). Aminoguanidine (AG) scavenges GDPs and prevents the formation of AGEs. Methods. In a peritoneal dialysis (PD) rat model, we evaluated the effects of the addition of AG to the PDF on microcirculation and morphology of the peritoneum, by intravital microscopy and quantitative morphometric analysis. Results. AG-bicarbonate effectively scavenged different GDPs from PDF. Daily exposure to PDF for 5 weeks resulted in a significant increase in leucocyte rolling in mesenteric venules, which could be reduced for ∼50% by addition of AG-bicarbonate (P<0.02). Vascular leakage was found in rats treated with PDF/AG-bicarbonate, but not with PDF alone. Evaluation of visceral and parietal peritoneum showed the induction of angiogenesis and fibrosis after PDF instillation. PDF/AG-bicarbonate significantly reduced vessel density in omentum and parietal peritoneum (P<0.04), but not in mesentery. PDF-induced fibrosis was significantly reduced by AG (P<0.02). PDF instillation led to AGE accumulation in mesentery, which was inhibited by supplementation of AG. Since addition of AG-bicarbonate to PDF raised pH from 5.2 to 8.5, a similar experiment was performed with AG-hydrochloride that did not change the fluid acidity. We could reproduce most of the results obtained with AG-bicarbonate; however, AG-hydrochloride induced no microvascular leakage and had a minor effect on angiogenesis. Conclusion. The supplementation of either AG reduced a number of PDF-induced alterations in our model, emphasizing the involvement of GDPs and/or AGEs in the PDF-induced peritoneal injury.</description><identifier>ISSN: 0931-0509</identifier><identifier>EISSN: 1460-2385</identifier><identifier>DOI: 10.1093/ndt/gfi138</identifier><identifier>PMID: 16204296</identifier><identifier>CODEN: NDTREA</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>aminoguanidine ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; angiogenesis ; Animals ; Biological and medical sciences ; Dialysis Solutions - pharmacology ; Disease Models, Animal ; Emergency and intensive care: renal failure. Dialysis management ; Enzyme Inhibitors - pharmacology ; fibrosis ; Fibrosis - etiology ; Fibrosis - pathology ; Fibrosis - prevention & control ; Glomerulonephritis ; Glycation End Products, Advanced - antagonists & inhibitors ; Guanidines - pharmacology ; Intensive care medicine ; Male ; Medical sciences ; Microcirculation - drug effects ; Microscopy, Electron ; Neovascularization, Pathologic - prevention & control ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Nitric Oxide Synthase - antagonists & inhibitors ; Oxidative Stress - drug effects ; peritoneal dialysis ; Peritoneal Dialysis - adverse effects ; Peritoneal Dialysis - methods ; Peritoneal Diseases - etiology ; Peritoneal Diseases - metabolism ; Peritoneal Diseases - prevention & control ; Peritoneum - blood supply ; Peritoneum - ultrastructure ; Pharmacology. Drug treatments ; Rats ; Rats, Wistar ; Urinary system</subject><ispartof>Nephrology, dialysis, transplantation, 2005-12, Vol.20 (12), p.2783-2792</ispartof><rights>2006 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Dec 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-5c69fbb8ccd254eec6da4dd8dce9c4d8a22d2a2a6298e3b9d9d5388686263af73</citedby><cites>FETCH-LOGICAL-c416t-5c69fbb8ccd254eec6da4dd8dce9c4d8a22d2a2a6298e3b9d9d5388686263af73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17320204$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16204296$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zareie, Mohammad</creatorcontrib><creatorcontrib>Tangelder, Geert-Jan</creatorcontrib><creatorcontrib>ter Wee, Piet M.</creatorcontrib><creatorcontrib>Hekking, Liesbeth HP</creatorcontrib><creatorcontrib>van Lambalgen, Anton A.</creatorcontrib><creatorcontrib>Keuning, Eelco D.</creatorcontrib><creatorcontrib>Schadee-Eestermans, Inge L.</creatorcontrib><creatorcontrib>Schalkwijk, Casper G.</creatorcontrib><creatorcontrib>Beelen, Robert HJ</creatorcontrib><creatorcontrib>van den Born, Jacob</creatorcontrib><title>Beneficial effects of aminoguanidine on peritoneal microcirculation and tissue remodelling in a rat model of PD</title><title>Nephrology, dialysis, transplantation</title><addtitle>Nephrol. Dial. Transplant</addtitle><description>Background. The formation of glucose degradation products (GDPs) and accumulation of advanced glycation end products (AGEs) partly contribute to the bioincompatibility of peritoneal dialysis fluids (PDF). Aminoguanidine (AG) scavenges GDPs and prevents the formation of AGEs. Methods. In a peritoneal dialysis (PD) rat model, we evaluated the effects of the addition of AG to the PDF on microcirculation and morphology of the peritoneum, by intravital microscopy and quantitative morphometric analysis. Results. AG-bicarbonate effectively scavenged different GDPs from PDF. Daily exposure to PDF for 5 weeks resulted in a significant increase in leucocyte rolling in mesenteric venules, which could be reduced for ∼50% by addition of AG-bicarbonate (P<0.02). Vascular leakage was found in rats treated with PDF/AG-bicarbonate, but not with PDF alone. Evaluation of visceral and parietal peritoneum showed the induction of angiogenesis and fibrosis after PDF instillation. PDF/AG-bicarbonate significantly reduced vessel density in omentum and parietal peritoneum (P<0.04), but not in mesentery. PDF-induced fibrosis was significantly reduced by AG (P<0.02). PDF instillation led to AGE accumulation in mesentery, which was inhibited by supplementation of AG. Since addition of AG-bicarbonate to PDF raised pH from 5.2 to 8.5, a similar experiment was performed with AG-hydrochloride that did not change the fluid acidity. We could reproduce most of the results obtained with AG-bicarbonate; however, AG-hydrochloride induced no microvascular leakage and had a minor effect on angiogenesis. Conclusion. The supplementation of either AG reduced a number of PDF-induced alterations in our model, emphasizing the involvement of GDPs and/or AGEs in the PDF-induced peritoneal injury.</description><subject>aminoguanidine</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>angiogenesis</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Dialysis Solutions - pharmacology</subject><subject>Disease Models, Animal</subject><subject>Emergency and intensive care: renal failure. Dialysis management</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>fibrosis</subject><subject>Fibrosis - etiology</subject><subject>Fibrosis - pathology</subject><subject>Fibrosis - prevention & control</subject><subject>Glomerulonephritis</subject><subject>Glycation End Products, Advanced - antagonists & inhibitors</subject><subject>Guanidines - pharmacology</subject><subject>Intensive care medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microcirculation - drug effects</subject><subject>Microscopy, Electron</subject><subject>Neovascularization, Pathologic - prevention & control</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Nitric Oxide Synthase - antagonists & inhibitors</subject><subject>Oxidative Stress - drug effects</subject><subject>peritoneal dialysis</subject><subject>Peritoneal Dialysis - adverse effects</subject><subject>Peritoneal Dialysis - methods</subject><subject>Peritoneal Diseases - etiology</subject><subject>Peritoneal Diseases - metabolism</subject><subject>Peritoneal Diseases - prevention & control</subject><subject>Peritoneum - blood supply</subject><subject>Peritoneum - ultrastructure</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Urinary system</subject><issn>0931-0509</issn><issn>1460-2385</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0VtrFDEUB_Agit1WX_wAEgT7IIzNZSaTPNZqW2HxAt7wJWSTkyV1JlmTDOi3N3UXCz4Fzv_H4eQchJ5Q8pISxc-iq2dbHyiX99CK9oJ0jMvhPlq1kHZkIOoIHZdyQwhRbBwfoiMqGOmZEiuUXkEEH2wwEwbvwdaCk8dmDjFtFxODCxFwingHOdQUobk52JxsyHaZTA0tM9HhGkpZAGeYk4NpCnGLQ0twNhX_Ld22_fD6EXrgzVTg8eE9QZ8v33y6uO7W76_eXpyvO9tTUbvBCuU3G2mtY0MPYIUzvXPSWVC2d9Iw5phhRjAlgW-UU27gUgopmODGj_wEne777nL6uUCpeg7FtsFMhLQULaRs2xl5g8_-gzdpybHNphmVVAx87Bt6sUft46Vk8HqXw2zyb02Jvr2BbjfQ-xs0_PTQcdnM4O7oYekNPD8AU6yZfDbRhnLnRs5Io811exdKhV__cpN_aDHycdDX377rj8P6y1dx9U5f8j_bnaC5</recordid><startdate>20051201</startdate><enddate>20051201</enddate><creator>Zareie, Mohammad</creator><creator>Tangelder, Geert-Jan</creator><creator>ter Wee, Piet M.</creator><creator>Hekking, Liesbeth HP</creator><creator>van Lambalgen, Anton A.</creator><creator>Keuning, Eelco D.</creator><creator>Schadee-Eestermans, Inge L.</creator><creator>Schalkwijk, Casper G.</creator><creator>Beelen, Robert HJ</creator><creator>van den Born, Jacob</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20051201</creationdate><title>Beneficial effects of aminoguanidine on peritoneal microcirculation and tissue remodelling in a rat model of PD</title><author>Zareie, Mohammad ; Tangelder, Geert-Jan ; ter Wee, Piet M. ; Hekking, Liesbeth HP ; van Lambalgen, Anton A. ; Keuning, Eelco D. ; Schadee-Eestermans, Inge L. ; Schalkwijk, Casper G. ; Beelen, Robert HJ ; van den Born, Jacob</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-5c69fbb8ccd254eec6da4dd8dce9c4d8a22d2a2a6298e3b9d9d5388686263af73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>aminoguanidine</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>angiogenesis</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Dialysis Solutions - pharmacology</topic><topic>Disease Models, Animal</topic><topic>Emergency and intensive care: renal failure. Dialysis management</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>fibrosis</topic><topic>Fibrosis - etiology</topic><topic>Fibrosis - pathology</topic><topic>Fibrosis - prevention & control</topic><topic>Glomerulonephritis</topic><topic>Glycation End Products, Advanced - antagonists & inhibitors</topic><topic>Guanidines - pharmacology</topic><topic>Intensive care medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microcirculation - drug effects</topic><topic>Microscopy, Electron</topic><topic>Neovascularization, Pathologic - prevention & control</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Nitric Oxide Synthase - antagonists & inhibitors</topic><topic>Oxidative Stress - drug effects</topic><topic>peritoneal dialysis</topic><topic>Peritoneal Dialysis - adverse effects</topic><topic>Peritoneal Dialysis - methods</topic><topic>Peritoneal Diseases - etiology</topic><topic>Peritoneal Diseases - metabolism</topic><topic>Peritoneal Diseases - prevention & control</topic><topic>Peritoneum - blood supply</topic><topic>Peritoneum - ultrastructure</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Urinary system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zareie, Mohammad</creatorcontrib><creatorcontrib>Tangelder, Geert-Jan</creatorcontrib><creatorcontrib>ter Wee, Piet M.</creatorcontrib><creatorcontrib>Hekking, Liesbeth HP</creatorcontrib><creatorcontrib>van Lambalgen, Anton A.</creatorcontrib><creatorcontrib>Keuning, Eelco D.</creatorcontrib><creatorcontrib>Schadee-Eestermans, Inge L.</creatorcontrib><creatorcontrib>Schalkwijk, Casper G.</creatorcontrib><creatorcontrib>Beelen, Robert HJ</creatorcontrib><creatorcontrib>van den Born, Jacob</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Nephrology, dialysis, transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zareie, Mohammad</au><au>Tangelder, Geert-Jan</au><au>ter Wee, Piet M.</au><au>Hekking, Liesbeth HP</au><au>van Lambalgen, Anton A.</au><au>Keuning, Eelco D.</au><au>Schadee-Eestermans, Inge L.</au><au>Schalkwijk, Casper G.</au><au>Beelen, Robert HJ</au><au>van den Born, Jacob</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Beneficial effects of aminoguanidine on peritoneal microcirculation and tissue remodelling in a rat model of PD</atitle><jtitle>Nephrology, dialysis, transplantation</jtitle><addtitle>Nephrol. Dial. Transplant</addtitle><date>2005-12-01</date><risdate>2005</risdate><volume>20</volume><issue>12</issue><spage>2783</spage><epage>2792</epage><pages>2783-2792</pages><issn>0931-0509</issn><eissn>1460-2385</eissn><coden>NDTREA</coden><abstract>Background. The formation of glucose degradation products (GDPs) and accumulation of advanced glycation end products (AGEs) partly contribute to the bioincompatibility of peritoneal dialysis fluids (PDF). Aminoguanidine (AG) scavenges GDPs and prevents the formation of AGEs. Methods. In a peritoneal dialysis (PD) rat model, we evaluated the effects of the addition of AG to the PDF on microcirculation and morphology of the peritoneum, by intravital microscopy and quantitative morphometric analysis. Results. AG-bicarbonate effectively scavenged different GDPs from PDF. Daily exposure to PDF for 5 weeks resulted in a significant increase in leucocyte rolling in mesenteric venules, which could be reduced for ∼50% by addition of AG-bicarbonate (P<0.02). Vascular leakage was found in rats treated with PDF/AG-bicarbonate, but not with PDF alone. Evaluation of visceral and parietal peritoneum showed the induction of angiogenesis and fibrosis after PDF instillation. PDF/AG-bicarbonate significantly reduced vessel density in omentum and parietal peritoneum (P<0.04), but not in mesentery. PDF-induced fibrosis was significantly reduced by AG (P<0.02). PDF instillation led to AGE accumulation in mesentery, which was inhibited by supplementation of AG. Since addition of AG-bicarbonate to PDF raised pH from 5.2 to 8.5, a similar experiment was performed with AG-hydrochloride that did not change the fluid acidity. We could reproduce most of the results obtained with AG-bicarbonate; however, AG-hydrochloride induced no microvascular leakage and had a minor effect on angiogenesis. Conclusion. The supplementation of either AG reduced a number of PDF-induced alterations in our model, emphasizing the involvement of GDPs and/or AGEs in the PDF-induced peritoneal injury.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>16204296</pmid><doi>10.1093/ndt/gfi138</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Nephrology, dialysis, transplantation, 2005-12, Vol.20 (12), p.2783-2792 |
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| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | aminoguanidine Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy angiogenesis Animals Biological and medical sciences Dialysis Solutions - pharmacology Disease Models, Animal Emergency and intensive care: renal failure. Dialysis management Enzyme Inhibitors - pharmacology fibrosis Fibrosis - etiology Fibrosis - pathology Fibrosis - prevention & control Glomerulonephritis Glycation End Products, Advanced - antagonists & inhibitors Guanidines - pharmacology Intensive care medicine Male Medical sciences Microcirculation - drug effects Microscopy, Electron Neovascularization, Pathologic - prevention & control Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Nitric Oxide Synthase - antagonists & inhibitors Oxidative Stress - drug effects peritoneal dialysis Peritoneal Dialysis - adverse effects Peritoneal Dialysis - methods Peritoneal Diseases - etiology Peritoneal Diseases - metabolism Peritoneal Diseases - prevention & control Peritoneum - blood supply Peritoneum - ultrastructure Pharmacology. Drug treatments Rats Rats, Wistar Urinary system |
| title | Beneficial effects of aminoguanidine on peritoneal microcirculation and tissue remodelling in a rat model of PD |
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