Structure and regulation of Kit protein-tyrosine kinase—The stem cell factor receptor

Signaling by stem cell factor and Kit, its receptor, play important roles in gametogenesis, hematopoiesis, mast cell development and function, and melanogenesis. Moreover, human and mouse embryonic stem cells express Kit transcripts. Stem cell factor exists as both a soluble and a membrane-bound gly...

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Veröffentlicht in:	Biochemical and biophysical research communications 2005-12, Vol.338 (3), p.1307-1315
1. Verfasser:	Roskoski, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Abl Activation loop Acute myelogenous leukemia Animals Bcr-Abl Benzamides Cell signaling Chronic myelogenous leukemia Dysgerminoma Flt3 Germ cells Gleevec Humans Imatinib Mesylate Mast cells Mutation - genetics Nasal T-cell lymphoma Neoplasms - genetics Neoplasms - metabolism Neoplasms - therapy Oncogene Piperazines - pharmacology Proto-oncogene Proto-Oncogene Proteins c-kit - chemistry Proto-Oncogene Proteins c-kit - genetics Proto-Oncogene Proteins c-kit - metabolism Pyrimidines - pharmacology Seminoma Signal Transduction STI-571 Targeted cancer therapy
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