Antihypertensive 1,4-Dihydropyridines as Correctors of the Cystic Fibrosis Transmembrane Conductance Regulator Channel Gating Defect Caused by Cystic Fibrosis Mutations

Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel gene. CF mutations like ΔF508 cause both a mistrafficking of the protein and a gating defect. Other mutations, like G551D, cause only a gating defect. Our aim was to find chemica...

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Veröffentlicht in:	Molecular pharmacology 2005-12, Vol.68 (6), p.1736-1746
Hauptverfasser:	Pedemonte, Nicoletta, Diena, Tullia, Caci, Emanuela, Nieddu, Erika, Mazzei, Mauro, Ravazzolo, Roberto, Zegarra-Moran, Olga, Galietta, Luis J.V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antihypertensive Agents - pharmacology Cystic Fibrosis - drug therapy Cystic Fibrosis - genetics Cystic Fibrosis Transmembrane Conductance Regulator - genetics Dihydropyridines - pharmacology Electrophysiology Ion Channel Gating - drug effects Ion Channel Gating - genetics Mice Mutation Rats Rats, Inbred F344 Thyroid Gland - cytology Transfection
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