Synthesis and antimalarial activities of some furoxan sulfones and related furazans
Furoxan derivatives bearing a sulfone moiety at position 3 or 4 were synthesized and tested for their antimalarial action on the chloroquine-sensitive D10 and the chloroquine-resistent W2 strains of Plasmodium falciparum. The furazan analogues were considered for comparison. The most active compound...
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| Veröffentlicht in: | European journal of medicinal chemistry 2005-12, Vol.40 (12), p.1335-1340 |
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| container_issue | 12 |
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| container_title | European journal of medicinal chemistry |
| container_volume | 40 |
| creator | Galli, Ubaldina Lazzarato, Loretta Bertinaria, Massimo Sorba, Giovanni Gasco, Alberto Parapini, Silvia Taramelli, Donatella |
| description | Furoxan derivatives bearing a sulfone moiety at position 3 or 4 were synthesized and tested for their antimalarial action on the chloroquine-sensitive D10 and the chloroquine-resistent W2 strains of
Plasmodium falciparum. The furazan analogues were considered for comparison. The most active compounds were the products in which the –SO
2R groups are at the 3-position of the furoxan system. These latter substances displayed an antimalarial activity in the μM range, possibly related in part to their ability to release NO. |
| doi_str_mv | 10.1016/j.ejmech.2005.05.001 |
| format | Article |
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2R groups are at the 3-position of the furoxan system. These latter substances displayed an antimalarial activity in the μM range, possibly related in part to their ability to release NO.</description><subject>Animals</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antimalarial</subject><subject>Antimalarials - chemical synthesis</subject><subject>Antimalarials - chemistry</subject><subject>Antimalarials - pharmacology</subject><subject>Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Furoxanyl sulfones</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Nitric oxide</subject><subject>Oxadiazoles - chemical synthesis</subject><subject>Oxadiazoles - chemistry</subject><subject>Oxadiazoles - pharmacology</subject><subject>Parasitic Sensitivity Tests</subject><subject>Pharmacology. 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| fulltext | fulltext |
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| ispartof | European journal of medicinal chemistry, 2005-12, Vol.40 (12), p.1335-1340 |
| issn | 0223-5234 1768-3254 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antimalarial Antimalarials - chemical synthesis Antimalarials - chemistry Antimalarials - pharmacology Antiparasitic agents Biological and medical sciences Furoxanyl sulfones Medical sciences Molecular Structure Nitric oxide Oxadiazoles - chemical synthesis Oxadiazoles - chemistry Oxadiazoles - pharmacology Parasitic Sensitivity Tests Pharmacology. Drug treatments Plasmodium falciparum Plasmodium falciparum - drug effects Structure-Activity Relationship |
| title | Synthesis and antimalarial activities of some furoxan sulfones and related furazans |
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