Brain Magnetic Resonance Spectroscopy in Tourette's Disorder
Although abnormalities of neural circuits involving the cortex, striatum, and thalamus are hypothesized to underlie Tourette's disorder, the neuronal abnormalities within components of these circuits are unknown. The purpose of this study was to examine the cellular neurochemistry within these...
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| Veröffentlicht in: | Journal of the American Academy of Child and Adolescent Psychiatry 2005-12, Vol.44 (12), p.1301-1308 |
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| creator | DEVITO, TIMOTHY J. DROST, DICK J. PAVLOSKY, WILLIAM NEUFELD, RICHARD W.J. RAJAKUMAR, NAGALINGAM MCKINLAY, B. DUNCAN WILLIAMSON, PETER C. NICOLSON, ROB |
| description | Although abnormalities of neural circuits involving the cortex, striatum, and thalamus are hypothesized to underlie Tourette's disorder, the neuronal abnormalities within components of these circuits are unknown. The purpose of this study was to examine the cellular neurochemistry within these circuits in Tourette's disorder using proton magnetic resonance spectroscopy, a method that has not previously been used in neurobiological investigations of the disorder.
Proton magnetic resonance spectroscopic imaging examinations were conducted in 25 males with Tourette's disorder (age 10.9 ± 2.0 years) and 32 male comparison subjects (age 11.5 ± 2.7 years). Spectra from frontal cortex, caudate nucleus, putamen, and thalamus were analyzed, and N-acetylaspartate, creatine, choline, myoinositol, and glutamate + glutamine were quantified and compared between the groups.
Patients with Tourette's disorder demonstrated a reduction in N-acetylaspartate and choline in the left putamen, along with reduced levels of creatine bilaterally in the putamen. In the frontal cortex, patients had significantly lower concentrations of N-acetylaspartate bilaterally, lower levels of creatine on the right side, and reduced myoinositol on the left side.
The results of this study suggest compromised neuronal integrity and deficits in density of neuronal and nonneuronal cells in components of the neural circuits implicated in Tourette's disorder. |
| doi_str_mv | 10.1097/01.chi.0000181046.52078.f4 |
| format | Article |
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Proton magnetic resonance spectroscopic imaging examinations were conducted in 25 males with Tourette's disorder (age 10.9 ± 2.0 years) and 32 male comparison subjects (age 11.5 ± 2.7 years). Spectra from frontal cortex, caudate nucleus, putamen, and thalamus were analyzed, and N-acetylaspartate, creatine, choline, myoinositol, and glutamate + glutamine were quantified and compared between the groups.
Patients with Tourette's disorder demonstrated a reduction in N-acetylaspartate and choline in the left putamen, along with reduced levels of creatine bilaterally in the putamen. In the frontal cortex, patients had significantly lower concentrations of N-acetylaspartate bilaterally, lower levels of creatine on the right side, and reduced myoinositol on the left side.
The results of this study suggest compromised neuronal integrity and deficits in density of neuronal and nonneuronal cells in components of the neural circuits implicated in Tourette's disorder.</description><identifier>ISSN: 0890-8567</identifier><identifier>EISSN: 1527-5418</identifier><identifier>DOI: 10.1097/01.chi.0000181046.52078.f4</identifier><identifier>PMID: 16292123</identifier><identifier>CODEN: JAAPEE</identifier><language>eng</language><publisher>Hagerstown, MD: Elsevier Inc</publisher><subject>Adolescent ; Adult and adolescent clinical studies ; Aspartic Acid - analogs & derivatives ; Aspartic Acid - metabolism ; basal ganglia ; Biochemistry ; Biological and medical sciences ; Biological Influences ; Brain ; Brain - physiopathology ; Brain Mapping ; Canada ; Chemistry ; Child ; Choline - metabolism ; Corpus Striatum - physiopathology ; Creatine - metabolism ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Dominance, Cerebral - physiology ; Energy Metabolism - physiology ; Female ; Foreign Countries ; Frontal Lobe - physiopathology ; Glutamic Acid - metabolism ; Glutamine - metabolism ; Humans ; Inositol - metabolism ; Magnetic Resonance Spectroscopy ; Male ; Males ; Medical sciences ; motor cortex ; Nerve Net - physiopathology ; Neurological Impairments ; Neurology ; Neurons ; Neurons - physiology ; Neuropsychology ; NMR ; Nuclear magnetic resonance ; Ontario ; Organic mental disorders. Neuropsychology ; Patients ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Reference Values ; Spectroscopy ; thalamus ; Thalamus - physiopathology ; Tourette Syndrome - diagnosis ; Tourette Syndrome - physiopathology ; Tourette's disorder</subject><ispartof>Journal of the American Academy of Child and Adolescent Psychiatry, 2005-12, Vol.44 (12), p.1301-1308</ispartof><rights>2005 The American Academy of Child and Adolescent Psychiatry</rights><rights>2006 INIST-CNRS</rights><rights>Copyright Lippincott Williams & Wilkins Dec 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-8c1c47aa99ec9f9d88aa9b74a5a1ee6c6810b6f3c035fd24cf040c0f48e27f6d3</citedby><cites>FETCH-LOGICAL-c456t-8c1c47aa99ec9f9d88aa9b74a5a1ee6c6810b6f3c035fd24cf040c0f48e27f6d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0890856709622437$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,30976,65534</link.rule.ids><backlink>$$Uhttp://eric.ed.gov/ERICWebPortal/detail?accno=EJ728064$$DView record in ERIC$$Hfree_for_read</backlink><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17333771$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16292123$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DEVITO, TIMOTHY J.</creatorcontrib><creatorcontrib>DROST, DICK J.</creatorcontrib><creatorcontrib>PAVLOSKY, WILLIAM</creatorcontrib><creatorcontrib>NEUFELD, RICHARD W.J.</creatorcontrib><creatorcontrib>RAJAKUMAR, NAGALINGAM</creatorcontrib><creatorcontrib>MCKINLAY, B. DUNCAN</creatorcontrib><creatorcontrib>WILLIAMSON, PETER C.</creatorcontrib><creatorcontrib>NICOLSON, ROB</creatorcontrib><title>Brain Magnetic Resonance Spectroscopy in Tourette's Disorder</title><title>Journal of the American Academy of Child and Adolescent Psychiatry</title><addtitle>J Am Acad Child Adolesc Psychiatry</addtitle><description>Although abnormalities of neural circuits involving the cortex, striatum, and thalamus are hypothesized to underlie Tourette's disorder, the neuronal abnormalities within components of these circuits are unknown. The purpose of this study was to examine the cellular neurochemistry within these circuits in Tourette's disorder using proton magnetic resonance spectroscopy, a method that has not previously been used in neurobiological investigations of the disorder.
Proton magnetic resonance spectroscopic imaging examinations were conducted in 25 males with Tourette's disorder (age 10.9 ± 2.0 years) and 32 male comparison subjects (age 11.5 ± 2.7 years). Spectra from frontal cortex, caudate nucleus, putamen, and thalamus were analyzed, and N-acetylaspartate, creatine, choline, myoinositol, and glutamate + glutamine were quantified and compared between the groups.
Patients with Tourette's disorder demonstrated a reduction in N-acetylaspartate and choline in the left putamen, along with reduced levels of creatine bilaterally in the putamen. In the frontal cortex, patients had significantly lower concentrations of N-acetylaspartate bilaterally, lower levels of creatine on the right side, and reduced myoinositol on the left side.
The results of this study suggest compromised neuronal integrity and deficits in density of neuronal and nonneuronal cells in components of the neural circuits implicated in Tourette's disorder.</description><subject>Adolescent</subject><subject>Adult and adolescent clinical studies</subject><subject>Aspartic Acid - analogs & derivatives</subject><subject>Aspartic Acid - metabolism</subject><subject>basal ganglia</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Biological Influences</subject><subject>Brain</subject><subject>Brain - physiopathology</subject><subject>Brain Mapping</subject><subject>Canada</subject><subject>Chemistry</subject><subject>Child</subject><subject>Choline - metabolism</subject><subject>Corpus Striatum - physiopathology</subject><subject>Creatine - metabolism</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Dominance, Cerebral - physiology</subject><subject>Energy Metabolism - physiology</subject><subject>Female</subject><subject>Foreign Countries</subject><subject>Frontal Lobe - physiopathology</subject><subject>Glutamic Acid - metabolism</subject><subject>Glutamine - metabolism</subject><subject>Humans</subject><subject>Inositol - metabolism</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Males</subject><subject>Medical sciences</subject><subject>motor cortex</subject><subject>Nerve Net - physiopathology</subject><subject>Neurological Impairments</subject><subject>Neurology</subject><subject>Neurons</subject><subject>Neurons - physiology</subject><subject>Neuropsychology</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Ontario</subject><subject>Organic mental disorders. Neuropsychology</subject><subject>Patients</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Reference Values</subject><subject>Spectroscopy</subject><subject>thalamus</subject><subject>Thalamus - physiopathology</subject><subject>Tourette Syndrome - diagnosis</subject><subject>Tourette Syndrome - physiopathology</subject><subject>Tourette's disorder</subject><issn>0890-8567</issn><issn>1527-5418</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqNkUuLFDEQgIO4uOPqPxBpFtRTt3l1khYvui-VFUHXc8hUVzTLTPeY9Aj7761xGgc8bS4J1Fepqq8YOxW8Ebyzr7lo4GdqOB3hBNemaSW3ron6AVuIVtq61cI9ZAvuOl671thj9riU2x1vnXvEjoWRnRRSLdjb9zmkofocfgw4Jai-YhmHMABW3zYIUx4LjJu7ipCbcZtxmvBVqc5TGXOP-Qk7imFV8Ol8n7Dvlxc3Zx_q6y9XH8_eXdegWzPVDgRoG0LXIXSx652j99Lq0AaBaMDQEEsTFXDVxl5qiFxz4FE7lDaaXp2wl_t_N3n8tcUy-XUqgKtVGHDcFm-c4063isDT_8Bb6nqg3jyNa5TppCXozR4Cmq5kjH6T0zrkOy-43wn2XHgS7A-C_V_BPmpKfj5X2C7X2B9SZ6MEvJiBUCCsYiaZqRw4q5SyVhD3bM9hTvAvfPHJSsfNrs75HCavvxNmXyAh7aVPmfbi-zHdp90_neOjEA</recordid><startdate>20051201</startdate><enddate>20051201</enddate><creator>DEVITO, TIMOTHY J.</creator><creator>DROST, DICK J.</creator><creator>PAVLOSKY, WILLIAM</creator><creator>NEUFELD, RICHARD W.J.</creator><creator>RAJAKUMAR, NAGALINGAM</creator><creator>MCKINLAY, B. DUNCAN</creator><creator>WILLIAMSON, PETER C.</creator><creator>NICOLSON, ROB</creator><general>Elsevier Inc</general><general>Lippincott Williams & Wilkins</general><general>Lippincott</general><general>Elsevier BV</general><scope>7SW</scope><scope>BJH</scope><scope>BNH</scope><scope>BNI</scope><scope>BNJ</scope><scope>BNO</scope><scope>ERI</scope><scope>PET</scope><scope>REK</scope><scope>WWN</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20051201</creationdate><title>Brain Magnetic Resonance Spectroscopy in Tourette's Disorder</title><author>DEVITO, TIMOTHY J. ; DROST, DICK J. ; PAVLOSKY, WILLIAM ; NEUFELD, RICHARD W.J. ; RAJAKUMAR, NAGALINGAM ; MCKINLAY, B. DUNCAN ; WILLIAMSON, PETER C. ; NICOLSON, ROB</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-8c1c47aa99ec9f9d88aa9b74a5a1ee6c6810b6f3c035fd24cf040c0f48e27f6d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult and adolescent clinical studies</topic><topic>Aspartic Acid - analogs & derivatives</topic><topic>Aspartic Acid - metabolism</topic><topic>basal ganglia</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Biological Influences</topic><topic>Brain</topic><topic>Brain - physiopathology</topic><topic>Brain Mapping</topic><topic>Canada</topic><topic>Chemistry</topic><topic>Child</topic><topic>Choline - metabolism</topic><topic>Corpus Striatum - physiopathology</topic><topic>Creatine - metabolism</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Dominance, Cerebral - physiology</topic><topic>Energy Metabolism - physiology</topic><topic>Female</topic><topic>Foreign Countries</topic><topic>Frontal Lobe - physiopathology</topic><topic>Glutamic Acid - metabolism</topic><topic>Glutamine - metabolism</topic><topic>Humans</topic><topic>Inositol - metabolism</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Males</topic><topic>Medical sciences</topic><topic>motor cortex</topic><topic>Nerve Net - physiopathology</topic><topic>Neurological Impairments</topic><topic>Neurology</topic><topic>Neurons</topic><topic>Neurons - physiology</topic><topic>Neuropsychology</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Ontario</topic><topic>Organic mental disorders. Neuropsychology</topic><topic>Patients</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Reference Values</topic><topic>Spectroscopy</topic><topic>thalamus</topic><topic>Thalamus - physiopathology</topic><topic>Tourette Syndrome - diagnosis</topic><topic>Tourette Syndrome - physiopathology</topic><topic>Tourette's disorder</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DEVITO, TIMOTHY J.</creatorcontrib><creatorcontrib>DROST, DICK J.</creatorcontrib><creatorcontrib>PAVLOSKY, WILLIAM</creatorcontrib><creatorcontrib>NEUFELD, RICHARD W.J.</creatorcontrib><creatorcontrib>RAJAKUMAR, NAGALINGAM</creatorcontrib><creatorcontrib>MCKINLAY, B. 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DUNCAN</au><au>WILLIAMSON, PETER C.</au><au>NICOLSON, ROB</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><ericid>EJ728064</ericid><atitle>Brain Magnetic Resonance Spectroscopy in Tourette's Disorder</atitle><jtitle>Journal of the American Academy of Child and Adolescent Psychiatry</jtitle><addtitle>J Am Acad Child Adolesc Psychiatry</addtitle><date>2005-12-01</date><risdate>2005</risdate><volume>44</volume><issue>12</issue><spage>1301</spage><epage>1308</epage><pages>1301-1308</pages><issn>0890-8567</issn><eissn>1527-5418</eissn><coden>JAAPEE</coden><abstract>Although abnormalities of neural circuits involving the cortex, striatum, and thalamus are hypothesized to underlie Tourette's disorder, the neuronal abnormalities within components of these circuits are unknown. The purpose of this study was to examine the cellular neurochemistry within these circuits in Tourette's disorder using proton magnetic resonance spectroscopy, a method that has not previously been used in neurobiological investigations of the disorder.
Proton magnetic resonance spectroscopic imaging examinations were conducted in 25 males with Tourette's disorder (age 10.9 ± 2.0 years) and 32 male comparison subjects (age 11.5 ± 2.7 years). Spectra from frontal cortex, caudate nucleus, putamen, and thalamus were analyzed, and N-acetylaspartate, creatine, choline, myoinositol, and glutamate + glutamine were quantified and compared between the groups.
Patients with Tourette's disorder demonstrated a reduction in N-acetylaspartate and choline in the left putamen, along with reduced levels of creatine bilaterally in the putamen. In the frontal cortex, patients had significantly lower concentrations of N-acetylaspartate bilaterally, lower levels of creatine on the right side, and reduced myoinositol on the left side.
The results of this study suggest compromised neuronal integrity and deficits in density of neuronal and nonneuronal cells in components of the neural circuits implicated in Tourette's disorder.</abstract><cop>Hagerstown, MD</cop><pub>Elsevier Inc</pub><pmid>16292123</pmid><doi>10.1097/01.chi.0000181046.52078.f4</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of the American Academy of Child and Adolescent Psychiatry, 2005-12, Vol.44 (12), p.1301-1308 |
| issn | 0890-8567 1527-5418 |
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| source | Applied Social Sciences Index & Abstracts (ASSIA); MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adolescent Adult and adolescent clinical studies Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism basal ganglia Biochemistry Biological and medical sciences Biological Influences Brain Brain - physiopathology Brain Mapping Canada Chemistry Child Choline - metabolism Corpus Striatum - physiopathology Creatine - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dominance, Cerebral - physiology Energy Metabolism - physiology Female Foreign Countries Frontal Lobe - physiopathology Glutamic Acid - metabolism Glutamine - metabolism Humans Inositol - metabolism Magnetic Resonance Spectroscopy Male Males Medical sciences motor cortex Nerve Net - physiopathology Neurological Impairments Neurology Neurons Neurons - physiology Neuropsychology NMR Nuclear magnetic resonance Ontario Organic mental disorders. Neuropsychology Patients Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Reference Values Spectroscopy thalamus Thalamus - physiopathology Tourette Syndrome - diagnosis Tourette Syndrome - physiopathology Tourette's disorder |
| title | Brain Magnetic Resonance Spectroscopy in Tourette's Disorder |
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