Structure-activity relationships of dengue antiviral polycyclic quinones
The virucidal and antiviral photoactivities of three compounds, hypericin, tetrabromohypericin and gymnochrome B, were evaluated against dengue viruses. All the three products were active, and both the virucidal and antiviral activities were enhanced by light. Gymnochrome B was more potent than hype...
Gespeichert in:
| Veröffentlicht in: | Southeast Asian journal of tropical medicine and public health 2005-07, Vol.36 (4), p.901-905 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 905 |
|---|---|
| container_issue | 4 |
| container_start_page | 901 |
| container_title | Southeast Asian journal of tropical medicine and public health |
| container_volume | 36 |
| creator | LAURENT, Dominique BAUMANN, Francine BENOIT, Anne Gaelle MORTELECQE, Alain NITATPATTANA, Narong DESVIGNES, Isabelle DEBITUS, Cécile LAILLE, Manola GONZALEZ, Jean-Paul CHUNGUE, Eliane |
| description | The virucidal and antiviral photoactivities of three compounds, hypericin, tetrabromohypericin and gymnochrome B, were evaluated against dengue viruses. All the three products were active, and both the virucidal and antiviral activities were enhanced by light. Gymnochrome B was more potent than hypericin and tetrabromohypericin. The presence of the side chains on the hypericin core of gymnochromes appears to be beneficial for both virucidal and antiviral activities. This enhanced activity is likely to be linked to a complementary mechanism independent of photoactivation. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_68808140</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68808140</sourcerecordid><originalsourceid>FETCH-LOGICAL-p181t-867538e7c1f0598eb6a84668a4be20f12685a873061d9a7937b6a7a77ca284743</originalsourceid><addsrcrecordid>eNpd0MtKAzEYBeAsFFurryCDoLuBJJPbLKWoFQou1PXwN81oSppMcxHm7R2xIrg6m4_D4ZygOSaU14QLOkPnKe0wZpi06gzNiKAt56yZo9VLjkXnEk0NOttPm8cqGgfZBp8-7JCq0Fdb49-LqcB_gwiuGoIb9aid1dWhWB-8SRfotAeXzOUxF-jt4f51uarXz49Py7t1PRBFcq2E5I0yUpMe81aZjQDFhFDANobinlChOCjZYEG2Lci2kZOQIKUGqphkzQLd_vQOMRyKSbnb26SNc-BNKKkTSmFFGJ7g9T-4CyX6aVtHMWGcYU4mdHVEZbM3226Idg9x7H4PmsDNEUDS4PoIXtv05yTlgrRt8wWzvW0f</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>201454051</pqid></control><display><type>article</type><title>Structure-activity relationships of dengue antiviral polycyclic quinones</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>LAURENT, Dominique ; BAUMANN, Francine ; BENOIT, Anne Gaelle ; MORTELECQE, Alain ; NITATPATTANA, Narong ; DESVIGNES, Isabelle ; DEBITUS, Cécile ; LAILLE, Manola ; GONZALEZ, Jean-Paul ; CHUNGUE, Eliane</creator><creatorcontrib>LAURENT, Dominique ; BAUMANN, Francine ; BENOIT, Anne Gaelle ; MORTELECQE, Alain ; NITATPATTANA, Narong ; DESVIGNES, Isabelle ; DEBITUS, Cécile ; LAILLE, Manola ; GONZALEZ, Jean-Paul ; CHUNGUE, Eliane</creatorcontrib><description>The virucidal and antiviral photoactivities of three compounds, hypericin, tetrabromohypericin and gymnochrome B, were evaluated against dengue viruses. All the three products were active, and both the virucidal and antiviral activities were enhanced by light. Gymnochrome B was more potent than hypericin and tetrabromohypericin. The presence of the side chains on the hypericin core of gymnochromes appears to be beneficial for both virucidal and antiviral activities. This enhanced activity is likely to be linked to a complementary mechanism independent of photoactivation.</description><identifier>ISSN: 0125-1562</identifier><identifier>PMID: 16295543</identifier><identifier>CODEN: SJTMAK</identifier><language>eng</language><publisher>Bangkok: Southeast Asian Ministers of Education Organization, Regional Tropical Medicine and Public Health Network</publisher><subject>Animals ; Arboviroses ; Biological and medical sciences ; Dengue fevers ; Dengue Virus ; Human viral diseases ; Infectious diseases ; Medical sciences ; Molecular Structure ; Polycyclic Aromatic Hydrocarbons ; Quinones ; Structure-Activity Relationship ; Tropical viral diseases ; Viral diseases</subject><ispartof>Southeast Asian journal of tropical medicine and public health, 2005-07, Vol.36 (4), p.901-905</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright Central Coordinating Board, SEAMEO-TROPMED Project Jul 2005</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17256199$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16295543$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LAURENT, Dominique</creatorcontrib><creatorcontrib>BAUMANN, Francine</creatorcontrib><creatorcontrib>BENOIT, Anne Gaelle</creatorcontrib><creatorcontrib>MORTELECQE, Alain</creatorcontrib><creatorcontrib>NITATPATTANA, Narong</creatorcontrib><creatorcontrib>DESVIGNES, Isabelle</creatorcontrib><creatorcontrib>DEBITUS, Cécile</creatorcontrib><creatorcontrib>LAILLE, Manola</creatorcontrib><creatorcontrib>GONZALEZ, Jean-Paul</creatorcontrib><creatorcontrib>CHUNGUE, Eliane</creatorcontrib><title>Structure-activity relationships of dengue antiviral polycyclic quinones</title><title>Southeast Asian journal of tropical medicine and public health</title><addtitle>Southeast Asian J Trop Med Public Health</addtitle><description>The virucidal and antiviral photoactivities of three compounds, hypericin, tetrabromohypericin and gymnochrome B, were evaluated against dengue viruses. All the three products were active, and both the virucidal and antiviral activities were enhanced by light. Gymnochrome B was more potent than hypericin and tetrabromohypericin. The presence of the side chains on the hypericin core of gymnochromes appears to be beneficial for both virucidal and antiviral activities. This enhanced activity is likely to be linked to a complementary mechanism independent of photoactivation.</description><subject>Animals</subject><subject>Arboviroses</subject><subject>Biological and medical sciences</subject><subject>Dengue fevers</subject><subject>Dengue Virus</subject><subject>Human viral diseases</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Polycyclic Aromatic Hydrocarbons</subject><subject>Quinones</subject><subject>Structure-Activity Relationship</subject><subject>Tropical viral diseases</subject><subject>Viral diseases</subject><issn>0125-1562</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpd0MtKAzEYBeAsFFurryCDoLuBJJPbLKWoFQou1PXwN81oSppMcxHm7R2xIrg6m4_D4ZygOSaU14QLOkPnKe0wZpi06gzNiKAt56yZo9VLjkXnEk0NOttPm8cqGgfZBp8-7JCq0Fdb49-LqcB_gwiuGoIb9aid1dWhWB-8SRfotAeXzOUxF-jt4f51uarXz49Py7t1PRBFcq2E5I0yUpMe81aZjQDFhFDANobinlChOCjZYEG2Lci2kZOQIKUGqphkzQLd_vQOMRyKSbnb26SNc-BNKKkTSmFFGJ7g9T-4CyX6aVtHMWGcYU4mdHVEZbM3226Idg9x7H4PmsDNEUDS4PoIXtv05yTlgrRt8wWzvW0f</recordid><startdate>200507</startdate><enddate>200507</enddate><creator>LAURENT, Dominique</creator><creator>BAUMANN, Francine</creator><creator>BENOIT, Anne Gaelle</creator><creator>MORTELECQE, Alain</creator><creator>NITATPATTANA, Narong</creator><creator>DESVIGNES, Isabelle</creator><creator>DEBITUS, Cécile</creator><creator>LAILLE, Manola</creator><creator>GONZALEZ, Jean-Paul</creator><creator>CHUNGUE, Eliane</creator><general>Southeast Asian Ministers of Education Organization, Regional Tropical Medicine and Public Health Network</general><general>Central Coordinating Board, SEAMEO-TROPMED Project</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7QL</scope><scope>7SS</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BVBZV</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PYCSY</scope><scope>7X8</scope></search><sort><creationdate>200507</creationdate><title>Structure-activity relationships of dengue antiviral polycyclic quinones</title><author>LAURENT, Dominique ; BAUMANN, Francine ; BENOIT, Anne Gaelle ; MORTELECQE, Alain ; NITATPATTANA, Narong ; DESVIGNES, Isabelle ; DEBITUS, Cécile ; LAILLE, Manola ; GONZALEZ, Jean-Paul ; CHUNGUE, Eliane</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p181t-867538e7c1f0598eb6a84668a4be20f12685a873061d9a7937b6a7a77ca284743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Arboviroses</topic><topic>Biological and medical sciences</topic><topic>Dengue fevers</topic><topic>Dengue Virus</topic><topic>Human viral diseases</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Molecular Structure</topic><topic>Polycyclic Aromatic Hydrocarbons</topic><topic>Quinones</topic><topic>Structure-Activity Relationship</topic><topic>Tropical viral diseases</topic><topic>Viral diseases</topic><toplevel>online_resources</toplevel><creatorcontrib>LAURENT, Dominique</creatorcontrib><creatorcontrib>BAUMANN, Francine</creatorcontrib><creatorcontrib>BENOIT, Anne Gaelle</creatorcontrib><creatorcontrib>MORTELECQE, Alain</creatorcontrib><creatorcontrib>NITATPATTANA, Narong</creatorcontrib><creatorcontrib>DESVIGNES, Isabelle</creatorcontrib><creatorcontrib>DEBITUS, Cécile</creatorcontrib><creatorcontrib>LAILLE, Manola</creatorcontrib><creatorcontrib>GONZALEZ, Jean-Paul</creatorcontrib><creatorcontrib>CHUNGUE, Eliane</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>East & South Asia Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Environmental Science Collection</collection><collection>MEDLINE - Academic</collection><jtitle>Southeast Asian journal of tropical medicine and public health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LAURENT, Dominique</au><au>BAUMANN, Francine</au><au>BENOIT, Anne Gaelle</au><au>MORTELECQE, Alain</au><au>NITATPATTANA, Narong</au><au>DESVIGNES, Isabelle</au><au>DEBITUS, Cécile</au><au>LAILLE, Manola</au><au>GONZALEZ, Jean-Paul</au><au>CHUNGUE, Eliane</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structure-activity relationships of dengue antiviral polycyclic quinones</atitle><jtitle>Southeast Asian journal of tropical medicine and public health</jtitle><addtitle>Southeast Asian J Trop Med Public Health</addtitle><date>2005-07</date><risdate>2005</risdate><volume>36</volume><issue>4</issue><spage>901</spage><epage>905</epage><pages>901-905</pages><issn>0125-1562</issn><coden>SJTMAK</coden><abstract>The virucidal and antiviral photoactivities of three compounds, hypericin, tetrabromohypericin and gymnochrome B, were evaluated against dengue viruses. All the three products were active, and both the virucidal and antiviral activities were enhanced by light. Gymnochrome B was more potent than hypericin and tetrabromohypericin. The presence of the side chains on the hypericin core of gymnochromes appears to be beneficial for both virucidal and antiviral activities. This enhanced activity is likely to be linked to a complementary mechanism independent of photoactivation.</abstract><cop>Bangkok</cop><pub>Southeast Asian Ministers of Education Organization, Regional Tropical Medicine and Public Health Network</pub><pmid>16295543</pmid><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0125-1562 |
| ispartof | Southeast Asian journal of tropical medicine and public health, 2005-07, Vol.36 (4), p.901-905 |
| issn | 0125-1562 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68808140 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Arboviroses Biological and medical sciences Dengue fevers Dengue Virus Human viral diseases Infectious diseases Medical sciences Molecular Structure Polycyclic Aromatic Hydrocarbons Quinones Structure-Activity Relationship Tropical viral diseases Viral diseases |
| title | Structure-activity relationships of dengue antiviral polycyclic quinones |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T01%3A51%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Structure-activity%20relationships%20of%20dengue%20antiviral%20polycyclic%20quinones&rft.jtitle=Southeast%20Asian%20journal%20of%20tropical%20medicine%20and%20public%20health&rft.au=LAURENT,%20Dominique&rft.date=2005-07&rft.volume=36&rft.issue=4&rft.spage=901&rft.epage=905&rft.pages=901-905&rft.issn=0125-1562&rft.coden=SJTMAK&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E68808140%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=201454051&rft_id=info:pmid/16295543&rfr_iscdi=true |