HLA class II restricted T-cell receptor gene transfer generates CD4+ T cells with helper activity as well as cytotoxic capacity

Both cytotoxic T cells and helper T cells are important in immune responses against pathogens and malignant cells. In hematological malignancies which express HLA class II molecules, immunotherapy may be directed to HLA class II restricted antigens. We investigated whether it is possible to engineer...

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Veröffentlicht in:	Gene therapy 2005-12, Vol.12 (23), p.1686-1695
Hauptverfasser:	van der Veken, L T, Hoogeboom, M, de Paus, R A, Willemze, R, Falkenburg, J H F, Heemskerk, M H M
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antigen receptors, T cell Antigens Applied cell therapy and gene therapy Biological and medical sciences Biomedical and Life Sciences Biomedicine Biotechnology CD4 antigen CD8 antigen Cell Biology Cells, Cultured Clone Cells Cytokines Cytolytic activity Cytotoxicity DNA helicase DNA Primers Feasibility studies Fundamental and applied biological sciences. Psychology Gene Expression Gene Therapy Gene transfer Genes, MHC Class II Genetic aspects Genetic Engineering Genetic Therapy - methods Genetic transformation Genetic Vectors - administration & dosage Genetic Vectors - genetics Health. Pharmaceutical industry Hematologic Neoplasms - immunology Hematologic Neoplasms - therapy Histocompatibility antigen HLA Histocompatibility antigens HLA histocompatibility antigens Human Genetics Humans Immunotherapy Immunotherapy - methods Industrial applications and implications. Economical aspects Lymphocytes Lymphocytes T Male Medical sciences Minor histocompatibility antigens Nanotechnology Peripheral blood Physiological aspects Receptors Receptors, Antigen, T-Cell - genetics research-article Retroviridae - genetics RNA helicase T cell receptors T cells T-Lymphocytes - immunology T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Helper-Inducer - immunology Transduction, Genetic - methods Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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