Influence of ischemia/hypoxia on the HIF-1 activity and expression of hypoxia-dependent genes in the cochlea of the newborn rat

Transcription factor HIF-1 (hypoxia-inducible factor-1) regulates the expression of genes which are involved in glucose supply, growth, metabolism, redox reactions and blood supply. Hypoxia and ischemia play an important role in the pathogenesis of tinnitus and hearing loss. Therefore, HIF-1 activit...

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Veröffentlicht in:	HNO 2006-09, Vol.54 (9), p.689-697
Hauptverfasser:	Mazurek, B, Rheinländer, C, Fuchs, F-U, Amarjargal, N, Kuban, R-J, Ungethüm, U, Haupt, H, Kietzmann, T, Gross, J
Format:	Artikel
Sprache:	ger
Schlagworte:	Animals Animals, Newborn Cell Hypoxia Cells, Cultured Cochlea - metabolism Gene Expression Regulation Hypoxia - metabolism Hypoxia-Inducible Factor 1 - metabolism Ischemia - metabolism Rats Rats, Wistar
Online-Zugang:	Volltext
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