Mechanical ventilation of very low birth weight infants: Is volume or pressure a better target variable?
To compare the efficacy and safety of volume-controlled (VC) ventilation to time-cycled pressure-limited (TCPL) ventilation in very low birth weight infants with respiratory distress syndrome (RDS). Newborns weighing between 600 and 1500 g and with a gestational age of 24 to 31 weeks who had RDS wer...
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| Veröffentlicht in: | The Journal of pediatrics 2006-09, Vol.149 (3), p.308-313 |
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| container_title | The Journal of pediatrics |
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| creator | Singh, Jaideep Sinha, Sunil K. Clarke, Paul Byrne, Steve Donn, Steven M. |
| description | To compare the efficacy and safety of volume-controlled (VC) ventilation to time-cycled pressure-limited (TCPL) ventilation in very low birth weight infants with respiratory distress syndrome (RDS).
Newborns weighing between 600 and 1500 g and with a gestational age of 24 to 31 weeks who had RDS were randomized to receive either VC or TCPL ventilation and treated with a standardized protocol. The 2 modalities were compared by determining the time required to achieve a predetermined success criterion, on the basis of either the alveolar-arterial oxygen gradient |
| doi_str_mv | 10.1016/j.jpeds.2006.01.044 |
| format | Article |
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Newborns weighing between 600 and 1500 g and with a gestational age of 24 to 31 weeks who had RDS were randomized to receive either VC or TCPL ventilation and treated with a standardized protocol. The 2 modalities were compared by determining the time required to achieve a predetermined success criterion, on the basis of either the alveolar-arterial oxygen gradient <100 mm Hg or the mean airway pressure <8 cm H
2O. Secondary outcomes included mortality, duration of mechanical ventilation, and complications commonly associated with ventilation.
The mean time to reach the success criterion was 23 hours in the VC group versus 33 hours in the TCPL group (
P = .15). This difference was more striking in babies weighing <1000g (21 versus 58 hours;
P = .03). Mean duration of ventilation with VC was 255 hours versus 327 hours with TCPL (
P = .60). There were 5 deaths in the VC group and 10 deaths in the TCPL group (
P = .10). The incidence of other complications was similar.
VC ventilation is safe and efficacious in very low birth weight infants and may have advantages when compared with TCPL, especially in smaller infants.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/j.jpeds.2006.01.044</identifier><identifier>PMID: 16939738</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Biological and medical sciences ; Diseases of mother, fetus and pregnancy ; Female ; General aspects ; Gynecology. Andrology. Obstetrics ; Humans ; Infant, Newborn ; Infant, Premature ; Infant, Very Low Birth Weight ; Lung Volume Measurements ; Male ; Medical sciences ; Pregnancy. Fetus. Placenta ; Pulmonary Gas Exchange - physiology ; Respiration, Artificial - methods ; Respiratory Distress Syndrome, Newborn - mortality ; Respiratory Distress Syndrome, Newborn - physiopathology ; Respiratory Distress Syndrome, Newborn - therapy ; Survival Rate ; Treatment Outcome</subject><ispartof>The Journal of pediatrics, 2006-09, Vol.149 (3), p.308-313</ispartof><rights>2006 Mosby, Inc.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-e8fe64f1f0fed8507f1fafac332c546bbfdfa1b9a9d4eefadfffead4248ec3ce3</citedby><cites>FETCH-LOGICAL-c387t-e8fe64f1f0fed8507f1fafac332c546bbfdfa1b9a9d4eefadfffead4248ec3ce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022347606000710$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18118472$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16939738$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Singh, Jaideep</creatorcontrib><creatorcontrib>Sinha, Sunil K.</creatorcontrib><creatorcontrib>Clarke, Paul</creatorcontrib><creatorcontrib>Byrne, Steve</creatorcontrib><creatorcontrib>Donn, Steven M.</creatorcontrib><title>Mechanical ventilation of very low birth weight infants: Is volume or pressure a better target variable?</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>To compare the efficacy and safety of volume-controlled (VC) ventilation to time-cycled pressure-limited (TCPL) ventilation in very low birth weight infants with respiratory distress syndrome (RDS).
Newborns weighing between 600 and 1500 g and with a gestational age of 24 to 31 weeks who had RDS were randomized to receive either VC or TCPL ventilation and treated with a standardized protocol. The 2 modalities were compared by determining the time required to achieve a predetermined success criterion, on the basis of either the alveolar-arterial oxygen gradient <100 mm Hg or the mean airway pressure <8 cm H
2O. Secondary outcomes included mortality, duration of mechanical ventilation, and complications commonly associated with ventilation.
The mean time to reach the success criterion was 23 hours in the VC group versus 33 hours in the TCPL group (
P = .15). This difference was more striking in babies weighing <1000g (21 versus 58 hours;
P = .03). Mean duration of ventilation with VC was 255 hours versus 327 hours with TCPL (
P = .60). There were 5 deaths in the VC group and 10 deaths in the TCPL group (
P = .10). The incidence of other complications was similar.
VC ventilation is safe and efficacious in very low birth weight infants and may have advantages when compared with TCPL, especially in smaller infants.</description><subject>Biological and medical sciences</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Female</subject><subject>General aspects</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infant, Very Low Birth Weight</subject><subject>Lung Volume Measurements</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Pulmonary Gas Exchange - physiology</subject><subject>Respiration, Artificial - methods</subject><subject>Respiratory Distress Syndrome, Newborn - mortality</subject><subject>Respiratory Distress Syndrome, Newborn - physiopathology</subject><subject>Respiratory Distress Syndrome, Newborn - therapy</subject><subject>Survival Rate</subject><subject>Treatment Outcome</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVJabZpf0Eh6JLe7I4sRZYLpZTQj0BKL-1ZjOVRVovX2kjyhvz7ersLufU0M_C8M8PD2DsBtQChP2zqzY6GXDcAugZRg1Iv2EpA11baSHnGVgBNU0nV6nP2OucNAHQK4BU7F7qTXSvNiq1_klvjFByOfE9TCSOWECce_TKmJz7GR96HVNb8kcL9uvAweZxK_shvM9_Hcd4Sj4nvEuU8J-LIeyqFEi-Y7qnwPaaA_Uif37CXHsdMb0_1gv359vX3zY_q7tf325svd5WTpi0VGU9aeeHB02CuoV1a9OikbNy10n3vB4-i77AbFJHHwXtPOKhGGXLSkbxg7497dyk-zJSL3YbsaBxxojhnq40B3apmAeURdCnmnMjbXQpbTE9WgD0Ithv7T7A9CLYg7CJ4SV2e1s_9lobnzMnoAlydAMyLVJ9wciE_c0YIo9rD-U9HjhYZ-0DJZhdocjSERK7YIYb_PvIXqUmeGg</recordid><startdate>20060901</startdate><enddate>20060901</enddate><creator>Singh, Jaideep</creator><creator>Sinha, Sunil K.</creator><creator>Clarke, Paul</creator><creator>Byrne, Steve</creator><creator>Donn, Steven M.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060901</creationdate><title>Mechanical ventilation of very low birth weight infants: Is volume or pressure a better target variable?</title><author>Singh, Jaideep ; Sinha, Sunil K. ; Clarke, Paul ; Byrne, Steve ; Donn, Steven M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-e8fe64f1f0fed8507f1fafac332c546bbfdfa1b9a9d4eefadfffead4248ec3ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Biological and medical sciences</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Female</topic><topic>General aspects</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Infant, Very Low Birth Weight</topic><topic>Lung Volume Measurements</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Pulmonary Gas Exchange - physiology</topic><topic>Respiration, Artificial - methods</topic><topic>Respiratory Distress Syndrome, Newborn - mortality</topic><topic>Respiratory Distress Syndrome, Newborn - physiopathology</topic><topic>Respiratory Distress Syndrome, Newborn - therapy</topic><topic>Survival Rate</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Singh, Jaideep</creatorcontrib><creatorcontrib>Sinha, Sunil K.</creatorcontrib><creatorcontrib>Clarke, Paul</creatorcontrib><creatorcontrib>Byrne, Steve</creatorcontrib><creatorcontrib>Donn, Steven M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Singh, Jaideep</au><au>Sinha, Sunil K.</au><au>Clarke, Paul</au><au>Byrne, Steve</au><au>Donn, Steven M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mechanical ventilation of very low birth weight infants: Is volume or pressure a better target variable?</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>2006-09-01</date><risdate>2006</risdate><volume>149</volume><issue>3</issue><spage>308</spage><epage>313</epage><pages>308-313</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>To compare the efficacy and safety of volume-controlled (VC) ventilation to time-cycled pressure-limited (TCPL) ventilation in very low birth weight infants with respiratory distress syndrome (RDS).
Newborns weighing between 600 and 1500 g and with a gestational age of 24 to 31 weeks who had RDS were randomized to receive either VC or TCPL ventilation and treated with a standardized protocol. The 2 modalities were compared by determining the time required to achieve a predetermined success criterion, on the basis of either the alveolar-arterial oxygen gradient <100 mm Hg or the mean airway pressure <8 cm H
2O. Secondary outcomes included mortality, duration of mechanical ventilation, and complications commonly associated with ventilation.
The mean time to reach the success criterion was 23 hours in the VC group versus 33 hours in the TCPL group (
P = .15). This difference was more striking in babies weighing <1000g (21 versus 58 hours;
P = .03). Mean duration of ventilation with VC was 255 hours versus 327 hours with TCPL (
P = .60). There were 5 deaths in the VC group and 10 deaths in the TCPL group (
P = .10). The incidence of other complications was similar.
VC ventilation is safe and efficacious in very low birth weight infants and may have advantages when compared with TCPL, especially in smaller infants.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>16939738</pmid><doi>10.1016/j.jpeds.2006.01.044</doi><tpages>6</tpages></addata></record> |
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| subjects | Biological and medical sciences Diseases of mother, fetus and pregnancy Female General aspects Gynecology. Andrology. Obstetrics Humans Infant, Newborn Infant, Premature Infant, Very Low Birth Weight Lung Volume Measurements Male Medical sciences Pregnancy. Fetus. Placenta Pulmonary Gas Exchange - physiology Respiration, Artificial - methods Respiratory Distress Syndrome, Newborn - mortality Respiratory Distress Syndrome, Newborn - physiopathology Respiratory Distress Syndrome, Newborn - therapy Survival Rate Treatment Outcome |
| title | Mechanical ventilation of very low birth weight infants: Is volume or pressure a better target variable? |
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