Control of multidrug resistance gene mdr1 and cancer resistance to chemotherapy by the longevity gene sirt1

Irreversible growth arrest (also called senescence) has emerged recently as a tumor suppressor mechanism and a key determinant of cancer chemotherapy outcome. Previous work from our laboratory suggested that the cellular ability to undergo or to escape senescence dictates its fate to become drug-sen...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2005-11, Vol.65 (22), p.10183-10187
Hauptverfasser:	FEI CHU, CHOU, Pauline M, XIN ZHENG, MIRKIN, Bernard L, REBBAA, Abdelhadi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Bone Neoplasms - drug therapy Bone Neoplasms - genetics Bone Neoplasms - metabolism Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Cell Line, Tumor Drug Resistance, Neoplasm - genetics Gene Expression Regulation, Neoplastic - genetics General aspects Genes, MDR - genetics Histone Deacetylases - biosynthesis Histone Deacetylases - genetics Humans Medical sciences Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism Neuroblastoma - drug therapy Neuroblastoma - genetics Neuroblastoma - metabolism Osteosarcoma - drug therapy Osteosarcoma - genetics Osteosarcoma - metabolism Pharmacology. Drug treatments RNA, Small Interfering - genetics Sirtuin 1 Sirtuins - biosynthesis Sirtuins - genetics Transfection
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