The Akt/PKB pathway: molecular target for cancer drug discovery

The serine/threonine kinase Akt/PKB pathway presents an exciting new target for molecular therapeutics, as it functions as a cardinal nodal point for transducing extracellular (growth factor and insulin) and intracellular (receptor tyrosine kinases, Ras and Src) oncogenic signals. In addition, alter...

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Veröffentlicht in:	Oncogene 2005-11, Vol.24 (50), p.7482-7492
Hauptverfasser:	Cheng, Jin Q, Lindsley, Craig W, Cheng, George Z, Yang, Hua, Nicosia, Santo V
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Angiogenesis Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Cancer Cell Biology Cell cycle Cell growth Cell migration Cell Proliferation - drug effects Cell survival Chemoresistance Combinatorial chemistry Ectopic expression Genetic transformation Growth inhibition Human Genetics Humans Insulin Internal Medicine Kinases Medicine Medicine & Public Health Mesenchyme Neoplasms - drug therapy Neoplasms - genetics Neoplasms - physiopathology Oncology Pharmaceutical sciences Phosphorylation Protein-serine/threonine kinase Proteins Proto-Oncogene Proteins c-akt - drug effects Proto-Oncogene Proteins c-akt - physiology review Signal Transduction Transgenic mice Tumor cells Tyrosine
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