Effect of zolpidem on the efficacy of continuous positive airway pressure as treatment for obstructive sleep apnea
Assess the effect of the hypnotic zolpidem on the efficacy of nasal continuous positive airway pressure for treatment of Obstructive Sleep Apnea. Randomized double blind placebo controlled, cross-over study. Veterans Administration Medical Center. 16 patients with severe obstructive sleep apnea (apn...
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| Veröffentlicht in: | Sleep (New York, N.Y.) N.Y.), 2006-08, Vol.29 (8), p.1052-1056 |
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| creator | BERRY, Richard B PATEL, Prakash B |
| description | Assess the effect of the hypnotic zolpidem on the efficacy of nasal continuous positive airway pressure for treatment of Obstructive Sleep Apnea.
Randomized double blind placebo controlled, cross-over study.
Veterans Administration Medical Center.
16 patients with severe obstructive sleep apnea (apnea+ hypopnea index > 30/hr), on CPAP therapy for at least 6 months.
Three sleep studies were performed over three consecutive weeks. On night one the pressure level required to prevent apnea, hypopnea, and snoring was determined. On the second and third study nights, either placebo (P) or 10 mg of zolpidem (Z) was given (random order) and subjects slept on the CPAP level determined on the first night.
Sleep architecture, apnea + hypopnea index, arterial oxygen saturation.
The sleep architecture was similar on the placebo and zolpidem nights except for a decrease in the sleep latency ( P: 23.5 +/- 4.7; Z: 13.1 +/- 3.3 minutes, P < 0.02) and a small decrease in the arousal index (P < 0.03) on zolpidem nights. The was no significant difference between placebo and zolpidem nights in the apnea + hypopnea index (P: 4.8 +/- 1.4 versus Z : 2.7 +/- 0.47 events/hour), oxygen desaturation index (1.46 +/- 0.53 versus 0.81 +/- 0.29 desaturations/hour), or the lowest SaO2 (91.4 +/- 0.6 versus 91.0 +/- 0.7%).
Acute administration of zolpidem 10 mg does not impair the efficacy of an effective level of CPAP in patients with severe obstructive sleep apnea. |
| doi_str_mv | 10.1093/sleep/29.8.1052 |
| format | Article |
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Randomized double blind placebo controlled, cross-over study.
Veterans Administration Medical Center.
16 patients with severe obstructive sleep apnea (apnea+ hypopnea index > 30/hr), on CPAP therapy for at least 6 months.
Three sleep studies were performed over three consecutive weeks. On night one the pressure level required to prevent apnea, hypopnea, and snoring was determined. On the second and third study nights, either placebo (P) or 10 mg of zolpidem (Z) was given (random order) and subjects slept on the CPAP level determined on the first night.
Sleep architecture, apnea + hypopnea index, arterial oxygen saturation.
The sleep architecture was similar on the placebo and zolpidem nights except for a decrease in the sleep latency ( P: 23.5 +/- 4.7; Z: 13.1 +/- 3.3 minutes, P < 0.02) and a small decrease in the arousal index (P < 0.03) on zolpidem nights. The was no significant difference between placebo and zolpidem nights in the apnea + hypopnea index (P: 4.8 +/- 1.4 versus Z : 2.7 +/- 0.47 events/hour), oxygen desaturation index (1.46 +/- 0.53 versus 0.81 +/- 0.29 desaturations/hour), or the lowest SaO2 (91.4 +/- 0.6 versus 91.0 +/- 0.7%).
Acute administration of zolpidem 10 mg does not impair the efficacy of an effective level of CPAP in patients with severe obstructive sleep apnea.</description><identifier>ISSN: 0161-8105</identifier><identifier>EISSN: 1550-9109</identifier><identifier>DOI: 10.1093/sleep/29.8.1052</identifier><identifier>PMID: 16944674</identifier><identifier>CODEN: SLEED6</identifier><language>eng</language><publisher>Rochester, MN: American Academy of Sleep Medicine</publisher><subject>Adult ; Arousal - drug effects ; Biological and medical sciences ; Body Mass Index ; Combined Modality Therapy ; Continuous Positive Airway Pressure ; Cross-Over Studies ; Diseases of the upper aerodigestive tract ; Double-Blind Method ; Ent and stomatology ; Female ; Humans ; Hypnotics and Sedatives - therapeutic use ; Male ; Medical sciences ; Middle Aged ; Obesity - complications ; Oxygen - blood ; Pneumology ; Polysomnography - drug effects ; Pyridines - therapeutic use ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Respiratory system : syndromes and miscellaneous diseases ; Sleep Apnea, Obstructive - therapy ; Sleep Initiation and Maintenance Disorders - drug therapy ; Snoring - therapy ; Treatment Outcome ; Zolpidem</subject><ispartof>Sleep (New York, N.Y.), 2006-08, Vol.29 (8), p.1052-1056</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-9437e54fccf3596a46bd157e4bd781e7c222f13b11c5679ec9e75410ede282643</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18035205$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16944674$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BERRY, Richard B</creatorcontrib><creatorcontrib>PATEL, Prakash B</creatorcontrib><title>Effect of zolpidem on the efficacy of continuous positive airway pressure as treatment for obstructive sleep apnea</title><title>Sleep (New York, N.Y.)</title><addtitle>Sleep</addtitle><description>Assess the effect of the hypnotic zolpidem on the efficacy of nasal continuous positive airway pressure for treatment of Obstructive Sleep Apnea.
Randomized double blind placebo controlled, cross-over study.
Veterans Administration Medical Center.
16 patients with severe obstructive sleep apnea (apnea+ hypopnea index > 30/hr), on CPAP therapy for at least 6 months.
Three sleep studies were performed over three consecutive weeks. On night one the pressure level required to prevent apnea, hypopnea, and snoring was determined. On the second and third study nights, either placebo (P) or 10 mg of zolpidem (Z) was given (random order) and subjects slept on the CPAP level determined on the first night.
Sleep architecture, apnea + hypopnea index, arterial oxygen saturation.
The sleep architecture was similar on the placebo and zolpidem nights except for a decrease in the sleep latency ( P: 23.5 +/- 4.7; Z: 13.1 +/- 3.3 minutes, P < 0.02) and a small decrease in the arousal index (P < 0.03) on zolpidem nights. The was no significant difference between placebo and zolpidem nights in the apnea + hypopnea index (P: 4.8 +/- 1.4 versus Z : 2.7 +/- 0.47 events/hour), oxygen desaturation index (1.46 +/- 0.53 versus 0.81 +/- 0.29 desaturations/hour), or the lowest SaO2 (91.4 +/- 0.6 versus 91.0 +/- 0.7%).
Acute administration of zolpidem 10 mg does not impair the efficacy of an effective level of CPAP in patients with severe obstructive sleep apnea.</description><subject>Adult</subject><subject>Arousal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Combined Modality Therapy</subject><subject>Continuous Positive Airway Pressure</subject><subject>Cross-Over Studies</subject><subject>Diseases of the upper aerodigestive tract</subject><subject>Double-Blind Method</subject><subject>Ent and stomatology</subject><subject>Female</subject><subject>Humans</subject><subject>Hypnotics and Sedatives - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Obesity - complications</subject><subject>Oxygen - blood</subject><subject>Pneumology</subject><subject>Polysomnography - drug effects</subject><subject>Pyridines - therapeutic use</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>Sleep Apnea, Obstructive - therapy</subject><subject>Sleep Initiation and Maintenance Disorders - drug therapy</subject><subject>Snoring - therapy</subject><subject>Treatment Outcome</subject><subject>Zolpidem</subject><issn>0161-8105</issn><issn>1550-9109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1r3DAQxUVoyW43OecWdGlvzurTto5l2bSBhVzas5DlEVWxLVeSW7Z_fbQfkNPweL95zDyEHih5okTxbRoA5i1TT23Rkt2gNZWSVKqYH9Ca0JpWbTFW6FNKv0nRQvFbtKK1EqJuxBrFvXNgMw4O_w_D7HsYcZhw_gUYnPPW2OPJs2HKflrCkvAcks_-L2Dj4z9zxHOElJZYdMI5gskjTBm7EHHoUo6LPcPnQ7GZJzB36KMzQ4L769ygn8_7H7vv1eH128vu66GygrNcKcEbkMJZ67hUtRF111PZgOj6pqXQWMaYo7yj1Mq6UWAVNFJQAj2wltWCb9CXS-4cw58FUtajTxaGwUxQHtF12xIhCC_g9gLaGFKK4PQc_WjiUVOiTzXr8_WaKd3qU81l4_EavXQj9O_8tdcCfL4CJlkzuGgm69M71xIuGZH8DWXWiJE</recordid><startdate>20060801</startdate><enddate>20060801</enddate><creator>BERRY, Richard B</creator><creator>PATEL, Prakash B</creator><general>American Academy of Sleep Medicine</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060801</creationdate><title>Effect of zolpidem on the efficacy of continuous positive airway pressure as treatment for obstructive sleep apnea</title><author>BERRY, Richard B ; PATEL, Prakash B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-9437e54fccf3596a46bd157e4bd781e7c222f13b11c5679ec9e75410ede282643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Arousal - drug effects</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Combined Modality Therapy</topic><topic>Continuous Positive Airway Pressure</topic><topic>Cross-Over Studies</topic><topic>Diseases of the upper aerodigestive tract</topic><topic>Double-Blind Method</topic><topic>Ent and stomatology</topic><topic>Female</topic><topic>Humans</topic><topic>Hypnotics and Sedatives - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Obesity - complications</topic><topic>Oxygen - blood</topic><topic>Pneumology</topic><topic>Polysomnography - drug effects</topic><topic>Pyridines - therapeutic use</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>Sleep Apnea, Obstructive - therapy</topic><topic>Sleep Initiation and Maintenance Disorders - drug therapy</topic><topic>Snoring - therapy</topic><topic>Treatment Outcome</topic><topic>Zolpidem</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BERRY, Richard B</creatorcontrib><creatorcontrib>PATEL, Prakash B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Sleep (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BERRY, Richard B</au><au>PATEL, Prakash B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of zolpidem on the efficacy of continuous positive airway pressure as treatment for obstructive sleep apnea</atitle><jtitle>Sleep (New York, N.Y.)</jtitle><addtitle>Sleep</addtitle><date>2006-08-01</date><risdate>2006</risdate><volume>29</volume><issue>8</issue><spage>1052</spage><epage>1056</epage><pages>1052-1056</pages><issn>0161-8105</issn><eissn>1550-9109</eissn><coden>SLEED6</coden><abstract>Assess the effect of the hypnotic zolpidem on the efficacy of nasal continuous positive airway pressure for treatment of Obstructive Sleep Apnea.
Randomized double blind placebo controlled, cross-over study.
Veterans Administration Medical Center.
16 patients with severe obstructive sleep apnea (apnea+ hypopnea index > 30/hr), on CPAP therapy for at least 6 months.
Three sleep studies were performed over three consecutive weeks. On night one the pressure level required to prevent apnea, hypopnea, and snoring was determined. On the second and third study nights, either placebo (P) or 10 mg of zolpidem (Z) was given (random order) and subjects slept on the CPAP level determined on the first night.
Sleep architecture, apnea + hypopnea index, arterial oxygen saturation.
The sleep architecture was similar on the placebo and zolpidem nights except for a decrease in the sleep latency ( P: 23.5 +/- 4.7; Z: 13.1 +/- 3.3 minutes, P < 0.02) and a small decrease in the arousal index (P < 0.03) on zolpidem nights. The was no significant difference between placebo and zolpidem nights in the apnea + hypopnea index (P: 4.8 +/- 1.4 versus Z : 2.7 +/- 0.47 events/hour), oxygen desaturation index (1.46 +/- 0.53 versus 0.81 +/- 0.29 desaturations/hour), or the lowest SaO2 (91.4 +/- 0.6 versus 91.0 +/- 0.7%).
Acute administration of zolpidem 10 mg does not impair the efficacy of an effective level of CPAP in patients with severe obstructive sleep apnea.</abstract><cop>Rochester, MN</cop><pub>American Academy of Sleep Medicine</pub><pmid>16944674</pmid><doi>10.1093/sleep/29.8.1052</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Sleep (New York, N.Y.), 2006-08, Vol.29 (8), p.1052-1056 |
| issn | 0161-8105 1550-9109 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Arousal - drug effects Biological and medical sciences Body Mass Index Combined Modality Therapy Continuous Positive Airway Pressure Cross-Over Studies Diseases of the upper aerodigestive tract Double-Blind Method Ent and stomatology Female Humans Hypnotics and Sedatives - therapeutic use Male Medical sciences Middle Aged Obesity - complications Oxygen - blood Pneumology Polysomnography - drug effects Pyridines - therapeutic use Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Respiratory system : syndromes and miscellaneous diseases Sleep Apnea, Obstructive - therapy Sleep Initiation and Maintenance Disorders - drug therapy Snoring - therapy Treatment Outcome Zolpidem |
| title | Effect of zolpidem on the efficacy of continuous positive airway pressure as treatment for obstructive sleep apnea |
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