Differential regulation of corticotropin-releasing factor receptor type 1 (CRF 1 receptor) mRNA via protein kinase A and mitogen-activated protein kinase pathways in rat anterior pituitary cells

Corticotropin-releasing factor (CRF) receptor type 1 (CRF 1 receptor) mRNA levels are down-regulated by CRF via the cyclic AMP-protein kinase A (PKA) pathway. In this study, we focused on the involvement of both the mitogen-activated protein (MAP) kinase pathway and PKA in this regulation. Real-time...

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Veröffentlicht in:	Molecular and cellular endocrinology 2005-11, Vol.243 (1), p.74-79
Hauptverfasser:	Moriyama, Takako, Kageyama, Kazunori, Kasagi, Yoko, Iwasaki, Yasumasa, Nigawara, Takeshi, Sakihara, Satoru, Suda, Toshihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anterior pituitary Cells, Cultured Corticotropin-releasing factor Corticotropin-releasing factor receptor Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Cyclic AMP-Dependent Protein Kinases - metabolism Dactinomycin - pharmacology Down-Regulation Imidazoles - pharmacology Male Mitogen-activated protein kinase Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism mRNA stability Pituitary Gland, Anterior - cytology Pituitary Gland, Anterior - drug effects Pituitary Gland, Anterior - metabolism Protein kinase A Pyridines - pharmacology Rats Rats, Wistar Receptors, Corticotropin-Releasing Hormone - genetics Receptors, Corticotropin-Releasing Hormone - metabolism RNA Stability RNA, Messenger - metabolism
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