Type I insulin-like growth factor receptor as a therapeutic target in cancer

Data from experimental model systems and population studies have implicated type I insulin-like growth factor receptor (IGF1R) signaling in many different human cancers. Drugs to disrupt IGF1R function have been developed and are now entering clinical trial. This brief review will identify key areas...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2005-11, Vol.65 (22), p.10123-10127
Hauptverfasser:	MILLER, Bradley S, YEE, Douglas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences General aspects Humans Medical sciences Neoplasms - drug therapy Neoplasms - therapy Pharmacology. Drug treatments Receptor, IGF Type 1 - antagonists & inhibitors Receptor, IGF Type 1 - metabolism
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Beschreibung
Zusammenfassung:	Data from experimental model systems and population studies have implicated type I insulin-like growth factor receptor (IGF1R) signaling in many different human cancers. Drugs to disrupt IGF1R function have been developed and are now entering clinical trial. This brief review will identify key areas to consider as these clinical trials move forward.
ISSN:	0008-5472 1538-7445
DOI:	10.1158/0008-5472.can-05-2752