Anxiolytic-like effects of short-term postnatal protein malnutrition in the elevated plus-maze test
Given that protein malnutrition induces structural, neurochemical and functional changes in the CNS, the present study aimed to investigate the effects of short-term early protein malnutrition on the behavior and reactivity to diazepam (DZ) in the elevated plus-maze test (EPM). Male Wistar rats ( n...
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| Veröffentlicht in: | Behavioural brain research 2006-10, Vol.173 (2), p.310-314 |
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| creator | Françolin-Silva, Ana Laura da Silva Hernandes, Andréa Fukuda, Marisa Tomoe Hebihara Valadares, Camila Tavares Almeida, Sebastião Sousa |
| description | Given that protein malnutrition induces structural, neurochemical and functional changes in the CNS, the present study aimed to investigate the effects of short-term early protein malnutrition on the behavior and reactivity to diazepam (DZ) in the elevated plus-maze test (EPM). Male Wistar rats (
n
=
176) from well-nourished (16%-protein) or malnourished litters (6%-protein) were distributed in five different groups: W (well-nourished), M7 (malnourished for 7 days), M14 (malnourished for 14 days), M21 (malnourished for 21 days) and M28 (malnourished for 28 days) since birthday. EPM results showed that the longer the exposition to the deficient diet, the lower the anxiety of malnourished animals, a result similar to that produced by the treatment with DZ. This anxiolytic-like effect suggested that short-term malnutrition may affect neural and/or neurochemical systems believed to underlie behavioral expression in anxiogenic experimental situations. |
| doi_str_mv | 10.1016/j.bbr.2006.06.042 |
| format | Article |
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n
=
176) from well-nourished (16%-protein) or malnourished litters (6%-protein) were distributed in five different groups: W (well-nourished), M7 (malnourished for 7 days), M14 (malnourished for 14 days), M21 (malnourished for 21 days) and M28 (malnourished for 28 days) since birthday. EPM results showed that the longer the exposition to the deficient diet, the lower the anxiety of malnourished animals, a result similar to that produced by the treatment with DZ. This anxiolytic-like effect suggested that short-term malnutrition may affect neural and/or neurochemical systems believed to underlie behavioral expression in anxiogenic experimental situations.</description><identifier>ISSN: 0166-4328</identifier><identifier>EISSN: 1872-7549</identifier><identifier>DOI: 10.1016/j.bbr.2006.06.042</identifier><identifier>PMID: 16919816</identifier><identifier>CODEN: BBREDI</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Animals ; Animals, Newborn ; Anti-Anxiety Agents - pharmacology ; Anxiety ; Behavior, Animal - drug effects ; Biological and medical sciences ; Body Weight - drug effects ; Body Weight - physiology ; Diazepam ; Diazepam - pharmacology ; Dose-Response Relationship, Drug ; Elevated plus-maze ; Exploratory Behavior - drug effects ; Exploratory Behavior - physiology ; Male ; Maze Learning - drug effects ; Maze Learning - physiology ; Medical sciences ; Metabolic diseases ; Neuropharmacology ; Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...) ; Pharmacology. Drug treatments ; Protein-Energy Malnutrition - physiopathology ; Psycholeptics: tranquillizer, neuroleptic ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Rats ; Rats, Wistar ; Short-term postnatal protein malnutrition</subject><ispartof>Behavioural brain research, 2006-10, Vol.173 (2), p.310-314</ispartof><rights>2006 Elsevier B.V.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-106a6fc667fd8d48ab1f4e8d92d3e30ce779c845f612dd691a7e79e681c16363</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0166432806003640$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18090376$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16919816$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Françolin-Silva, Ana Laura</creatorcontrib><creatorcontrib>da Silva Hernandes, Andréa</creatorcontrib><creatorcontrib>Fukuda, Marisa Tomoe Hebihara</creatorcontrib><creatorcontrib>Valadares, Camila Tavares</creatorcontrib><creatorcontrib>Almeida, Sebastião Sousa</creatorcontrib><title>Anxiolytic-like effects of short-term postnatal protein malnutrition in the elevated plus-maze test</title><title>Behavioural brain research</title><addtitle>Behav Brain Res</addtitle><description>Given that protein malnutrition induces structural, neurochemical and functional changes in the CNS, the present study aimed to investigate the effects of short-term early protein malnutrition on the behavior and reactivity to diazepam (DZ) in the elevated plus-maze test (EPM). Male Wistar rats (
n
=
176) from well-nourished (16%-protein) or malnourished litters (6%-protein) were distributed in five different groups: W (well-nourished), M7 (malnourished for 7 days), M14 (malnourished for 14 days), M21 (malnourished for 21 days) and M28 (malnourished for 28 days) since birthday. EPM results showed that the longer the exposition to the deficient diet, the lower the anxiety of malnourished animals, a result similar to that produced by the treatment with DZ. This anxiolytic-like effect suggested that short-term malnutrition may affect neural and/or neurochemical systems believed to underlie behavioral expression in anxiogenic experimental situations.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Anti-Anxiety Agents - pharmacology</subject><subject>Anxiety</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Body Weight - drug effects</subject><subject>Body Weight - physiology</subject><subject>Diazepam</subject><subject>Diazepam - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Elevated plus-maze</subject><subject>Exploratory Behavior - drug effects</subject><subject>Exploratory Behavior - physiology</subject><subject>Male</subject><subject>Maze Learning - drug effects</subject><subject>Maze Learning - physiology</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Neuropharmacology</subject><subject>Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)</subject><subject>Pharmacology. Drug treatments</subject><subject>Protein-Energy Malnutrition - physiopathology</subject><subject>Psycholeptics: tranquillizer, neuroleptic</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Short-term postnatal protein malnutrition</subject><issn>0166-4328</issn><issn>1872-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2LFDEQhoMo7rj6A7xILnrrMZXOJGk8LYu6Cwte9h4ySYXNmO4ek_Ti-utNMwN7UygoCp63vl5C3gPbAgP5-bDd7_OWMya3awj-gmxAK96pnRhekk1jZCd6ri_Im1IOjDHBdvCaXIAcYNAgN8RdTb_jnJ5qdF2KP5FiCOhqoXOg5WHOtauYR3qcS51stYke81wxTnS0aVpqjjXOE211fWjahI-2oqfHtJRutH-QViz1LXkVbCr47pwvyf23r_fXN93dj--311d3nRPAawdMWhmclCp47YW2ewgCtR-477FnDpUanBa7IIF73y6wCtWAUoMD2cv-knw6tW0r_lraXDPG4jAlO-G8FCO1ZnzH4L8gDL0AxXkD4QS6PJeSMZhjjqPNTwaYWR0wB9McMKsDZg2xaj6cmy_7Ef2z4vzyBnw8A7Y4m0K2k4vlmdNsYL1auS8nDtvLHiNmU1zEyaGPuTlk_Bz_scZfd4CkpA</recordid><startdate>20061016</startdate><enddate>20061016</enddate><creator>Françolin-Silva, Ana Laura</creator><creator>da Silva Hernandes, Andréa</creator><creator>Fukuda, Marisa Tomoe Hebihara</creator><creator>Valadares, Camila Tavares</creator><creator>Almeida, Sebastião Sousa</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20061016</creationdate><title>Anxiolytic-like effects of short-term postnatal protein malnutrition in the elevated plus-maze test</title><author>Françolin-Silva, Ana Laura ; da Silva Hernandes, Andréa ; Fukuda, Marisa Tomoe Hebihara ; Valadares, Camila Tavares ; Almeida, Sebastião Sousa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-106a6fc667fd8d48ab1f4e8d92d3e30ce779c845f612dd691a7e79e681c16363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Anti-Anxiety Agents - pharmacology</topic><topic>Anxiety</topic><topic>Behavior, Animal - drug effects</topic><topic>Biological and medical sciences</topic><topic>Body Weight - drug effects</topic><topic>Body Weight - physiology</topic><topic>Diazepam</topic><topic>Diazepam - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Elevated plus-maze</topic><topic>Exploratory Behavior - drug effects</topic><topic>Exploratory Behavior - physiology</topic><topic>Male</topic><topic>Maze Learning - drug effects</topic><topic>Maze Learning - physiology</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Neuropharmacology</topic><topic>Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)</topic><topic>Pharmacology. Drug treatments</topic><topic>Protein-Energy Malnutrition - physiopathology</topic><topic>Psycholeptics: tranquillizer, neuroleptic</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Short-term postnatal protein malnutrition</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Françolin-Silva, Ana Laura</creatorcontrib><creatorcontrib>da Silva Hernandes, Andréa</creatorcontrib><creatorcontrib>Fukuda, Marisa Tomoe Hebihara</creatorcontrib><creatorcontrib>Valadares, Camila Tavares</creatorcontrib><creatorcontrib>Almeida, Sebastião Sousa</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioural brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Françolin-Silva, Ana Laura</au><au>da Silva Hernandes, Andréa</au><au>Fukuda, Marisa Tomoe Hebihara</au><au>Valadares, Camila Tavares</au><au>Almeida, Sebastião Sousa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anxiolytic-like effects of short-term postnatal protein malnutrition in the elevated plus-maze test</atitle><jtitle>Behavioural brain research</jtitle><addtitle>Behav Brain Res</addtitle><date>2006-10-16</date><risdate>2006</risdate><volume>173</volume><issue>2</issue><spage>310</spage><epage>314</epage><pages>310-314</pages><issn>0166-4328</issn><eissn>1872-7549</eissn><coden>BBREDI</coden><abstract>Given that protein malnutrition induces structural, neurochemical and functional changes in the CNS, the present study aimed to investigate the effects of short-term early protein malnutrition on the behavior and reactivity to diazepam (DZ) in the elevated plus-maze test (EPM). Male Wistar rats (
n
=
176) from well-nourished (16%-protein) or malnourished litters (6%-protein) were distributed in five different groups: W (well-nourished), M7 (malnourished for 7 days), M14 (malnourished for 14 days), M21 (malnourished for 21 days) and M28 (malnourished for 28 days) since birthday. EPM results showed that the longer the exposition to the deficient diet, the lower the anxiety of malnourished animals, a result similar to that produced by the treatment with DZ. This anxiolytic-like effect suggested that short-term malnutrition may affect neural and/or neurochemical systems believed to underlie behavioral expression in anxiogenic experimental situations.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>16919816</pmid><doi>10.1016/j.bbr.2006.06.042</doi><tpages>5</tpages></addata></record> |
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| subjects | Animals Animals, Newborn Anti-Anxiety Agents - pharmacology Anxiety Behavior, Animal - drug effects Biological and medical sciences Body Weight - drug effects Body Weight - physiology Diazepam Diazepam - pharmacology Dose-Response Relationship, Drug Elevated plus-maze Exploratory Behavior - drug effects Exploratory Behavior - physiology Male Maze Learning - drug effects Maze Learning - physiology Medical sciences Metabolic diseases Neuropharmacology Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...) Pharmacology. Drug treatments Protein-Energy Malnutrition - physiopathology Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Wistar Short-term postnatal protein malnutrition |
| title | Anxiolytic-like effects of short-term postnatal protein malnutrition in the elevated plus-maze test |
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