Association of Plasma Resistin Levels with Coronary Heart Disease in Women
Objective: To examine the association between plasma resistin levels and the presence of coronary heart disease (CHD) in women. Research Methods and Procedures: Plasma resistin levels were measured in a case‐control study including 185 women with angiographically confirmed CHD and 227 population‐bas...
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| Veröffentlicht in: | Obesity (Silver Spring, Md.) Md.), 2005-10, Vol.13 (10), p.1764-1771 |
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| container_title | Obesity (Silver Spring, Md.) |
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| creator | Pischon, Tobias Bamberger, Christoph M. Kratzsch, Jürgen Zyriax, Birgit‐Christiane Algenstaedt, Petra Boeing, Heiner Windler, Eberhard |
| description | Objective: To examine the association between plasma resistin levels and the presence of coronary heart disease (CHD) in women.
Research Methods and Procedures: Plasma resistin levels were measured in a case‐control study including 185 women with angiographically confirmed CHD and 227 population‐based female controls from the Coronary Risk Factors for Atherosclerosis in Women (CORA) study.
Results: After adjustment for age, smoking, family history of myocardial infarction, retirement, education, physical activity, menopausal status, hormone replacement use, BMI, hypertension, diabetes, and dyslipidemia, the odds ratio for CHD for women in the highest compared with lowest quintile of plasma resistin levels was 3.19 (95% confidence interval, 1.44 to 7.10; p log trend, 0.001). After additional adjustment for plasma C‐reactive protein levels, this association was substantially attenuated and no longer significant (odds ratio, 1.80; 95% confidence interval, 0.69 ti 4.69; p trend = 0.23).
Discussion: These results suggest that plasma resistin levels are significantly associated with the presence of CHD in women; however, this association can largely be explained by concomitant inflammatory processes. Further studies are needed to determine the causal role of resistin in the development of CHD in humans. |
| doi_str_mv | 10.1038/oby.2005.215 |
| format | Article |
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Research Methods and Procedures: Plasma resistin levels were measured in a case‐control study including 185 women with angiographically confirmed CHD and 227 population‐based female controls from the Coronary Risk Factors for Atherosclerosis in Women (CORA) study.
Results: After adjustment for age, smoking, family history of myocardial infarction, retirement, education, physical activity, menopausal status, hormone replacement use, BMI, hypertension, diabetes, and dyslipidemia, the odds ratio for CHD for women in the highest compared with lowest quintile of plasma resistin levels was 3.19 (95% confidence interval, 1.44 to 7.10; p log trend, 0.001). After additional adjustment for plasma C‐reactive protein levels, this association was substantially attenuated and no longer significant (odds ratio, 1.80; 95% confidence interval, 0.69 ti 4.69; p trend = 0.23).
Discussion: These results suggest that plasma resistin levels are significantly associated with the presence of CHD in women; however, this association can largely be explained by concomitant inflammatory processes. Further studies are needed to determine the causal role of resistin in the development of CHD in humans.</description><identifier>ISSN: 1930-7381</identifier><identifier>ISSN: 1071-7323</identifier><identifier>EISSN: 1930-739X</identifier><identifier>EISSN: 1550-8528</identifier><identifier>DOI: 10.1038/oby.2005.215</identifier><identifier>PMID: 16286524</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>adipokine ; Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; Coronary Disease - blood ; coronary heart disease ; epidemiology ; Female ; Humans ; inflammation ; Middle Aged ; Resistin - blood ; risk factor</subject><ispartof>Obesity (Silver Spring, Md.), 2005-10, Vol.13 (10), p.1764-1771</ispartof><rights>2005 North American Association for the Study of Obesity (NAASO)</rights><rights>Copyright Nature Publishing Group Oct 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3842-7c822dc28409d5655ca51743cb3de3c73b226263b61f6f850c205632c92c7a5f3</citedby><cites>FETCH-LOGICAL-c3842-7c822dc28409d5655ca51743cb3de3c73b226263b61f6f850c205632c92c7a5f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1038%2Foby.2005.215$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1038%2Foby.2005.215$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,1432,27923,27924,45573,45574,46408,46832</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16286524$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pischon, Tobias</creatorcontrib><creatorcontrib>Bamberger, Christoph M.</creatorcontrib><creatorcontrib>Kratzsch, Jürgen</creatorcontrib><creatorcontrib>Zyriax, Birgit‐Christiane</creatorcontrib><creatorcontrib>Algenstaedt, Petra</creatorcontrib><creatorcontrib>Boeing, Heiner</creatorcontrib><creatorcontrib>Windler, Eberhard</creatorcontrib><title>Association of Plasma Resistin Levels with Coronary Heart Disease in Women</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obes Res</addtitle><description>Objective: To examine the association between plasma resistin levels and the presence of coronary heart disease (CHD) in women.
Research Methods and Procedures: Plasma resistin levels were measured in a case‐control study including 185 women with angiographically confirmed CHD and 227 population‐based female controls from the Coronary Risk Factors for Atherosclerosis in Women (CORA) study.
Results: After adjustment for age, smoking, family history of myocardial infarction, retirement, education, physical activity, menopausal status, hormone replacement use, BMI, hypertension, diabetes, and dyslipidemia, the odds ratio for CHD for women in the highest compared with lowest quintile of plasma resistin levels was 3.19 (95% confidence interval, 1.44 to 7.10; p log trend, 0.001). After additional adjustment for plasma C‐reactive protein levels, this association was substantially attenuated and no longer significant (odds ratio, 1.80; 95% confidence interval, 0.69 ti 4.69; p trend = 0.23).
Discussion: These results suggest that plasma resistin levels are significantly associated with the presence of CHD in women; however, this association can largely be explained by concomitant inflammatory processes. Further studies are needed to determine the causal role of resistin in the development of CHD in humans.</description><subject>adipokine</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Case-Control Studies</subject><subject>Coronary Disease - blood</subject><subject>coronary heart disease</subject><subject>epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>inflammation</subject><subject>Middle Aged</subject><subject>Resistin - blood</subject><subject>risk factor</subject><issn>1930-7381</issn><issn>1071-7323</issn><issn>1930-739X</issn><issn>1550-8528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90M1LwzAYBvAgipvTm2cJCJ7cTN40aXqc82PKYCKKeipplmKkbTRplf33ZmwoePCUHH7Pm7wPQoeUjChh8swVyxEQwkdA-Rbq04yRYcqy5-2fu6Q9tBfCGyGJIJzuoh4VIAWHpI9uxyE4bVVrXYNdie8qFWqF702wobUNnplPUwX8ZdtXPHHeNcov8dQo3-ILG4wKBkf15GrT7KOdUlXBHGzOAXq8unyYTIez-fXNZDwbaiYTGKZaAiw0yIRkCy4414rTNGG6YAvDdMoKAAGCFYKWopScaCBcMNAZ6FTxkg3QyXruu3cfnQltXtugTVWpxrgu5EJKQjPCIjz-A99c55v4tzw2R1LIEpJEdbpW2rsQvCnzd2_ruGZEKyfz2HC-ajiPDUd-tBnaFbVZ_OJNpRHQNfiylVn-Oyyfn79QIBAzeJ1pVNt58xOKeGVX734DL36Ouw</recordid><startdate>200510</startdate><enddate>200510</enddate><creator>Pischon, Tobias</creator><creator>Bamberger, Christoph M.</creator><creator>Kratzsch, Jürgen</creator><creator>Zyriax, Birgit‐Christiane</creator><creator>Algenstaedt, Petra</creator><creator>Boeing, Heiner</creator><creator>Windler, Eberhard</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200510</creationdate><title>Association of Plasma Resistin Levels with Coronary Heart Disease in Women</title><author>Pischon, Tobias ; Bamberger, Christoph M. ; Kratzsch, Jürgen ; Zyriax, Birgit‐Christiane ; Algenstaedt, Petra ; Boeing, Heiner ; Windler, Eberhard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3842-7c822dc28409d5655ca51743cb3de3c73b226263b61f6f850c205632c92c7a5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>adipokine</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Case-Control Studies</topic><topic>Coronary Disease - blood</topic><topic>coronary heart disease</topic><topic>epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>inflammation</topic><topic>Middle Aged</topic><topic>Resistin - blood</topic><topic>risk factor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pischon, Tobias</creatorcontrib><creatorcontrib>Bamberger, Christoph M.</creatorcontrib><creatorcontrib>Kratzsch, Jürgen</creatorcontrib><creatorcontrib>Zyriax, Birgit‐Christiane</creatorcontrib><creatorcontrib>Algenstaedt, Petra</creatorcontrib><creatorcontrib>Boeing, Heiner</creatorcontrib><creatorcontrib>Windler, Eberhard</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pischon, Tobias</au><au>Bamberger, Christoph M.</au><au>Kratzsch, Jürgen</au><au>Zyriax, Birgit‐Christiane</au><au>Algenstaedt, Petra</au><au>Boeing, Heiner</au><au>Windler, Eberhard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Plasma Resistin Levels with Coronary Heart Disease in Women</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obes Res</addtitle><date>2005-10</date><risdate>2005</risdate><volume>13</volume><issue>10</issue><spage>1764</spage><epage>1771</epage><pages>1764-1771</pages><issn>1930-7381</issn><issn>1071-7323</issn><eissn>1930-739X</eissn><eissn>1550-8528</eissn><abstract>Objective: To examine the association between plasma resistin levels and the presence of coronary heart disease (CHD) in women.
Research Methods and Procedures: Plasma resistin levels were measured in a case‐control study including 185 women with angiographically confirmed CHD and 227 population‐based female controls from the Coronary Risk Factors for Atherosclerosis in Women (CORA) study.
Results: After adjustment for age, smoking, family history of myocardial infarction, retirement, education, physical activity, menopausal status, hormone replacement use, BMI, hypertension, diabetes, and dyslipidemia, the odds ratio for CHD for women in the highest compared with lowest quintile of plasma resistin levels was 3.19 (95% confidence interval, 1.44 to 7.10; p log trend, 0.001). After additional adjustment for plasma C‐reactive protein levels, this association was substantially attenuated and no longer significant (odds ratio, 1.80; 95% confidence interval, 0.69 ti 4.69; p trend = 0.23).
Discussion: These results suggest that plasma resistin levels are significantly associated with the presence of CHD in women; however, this association can largely be explained by concomitant inflammatory processes. Further studies are needed to determine the causal role of resistin in the development of CHD in humans.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>16286524</pmid><doi>10.1038/oby.2005.215</doi><tpages>8</tpages></addata></record> |
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| subjects | adipokine Adult Aged Aged, 80 and over Case-Control Studies Coronary Disease - blood coronary heart disease epidemiology Female Humans inflammation Middle Aged Resistin - blood risk factor |
| title | Association of Plasma Resistin Levels with Coronary Heart Disease in Women |
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