A CpG-containing oligodeoxynucleotide as an efficient adjuvant counterbalancing the Th1/Th2 immune response in diphtheria–tetanus–pertussis vaccine
Adjuvants in vaccines are immune stimulants that play an important role in the induction of effective and appropriate immune responses to vaccine component(s). Diphtheria–tetanus–pertussis (DPT) vaccine contains not only aluminum hydrate (alum) to enhance the immune response to the vaccine ingredien...
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| Veröffentlicht in: | Vaccine 2005-11, Vol.23 (46), p.5450-5456 |
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| creator | Sugai, Toshiyuki Mori, Masaaki Nakazawa, Masatoshi Ichino, Motohide Naruto, Takuya Kobayashi, Naoki Kobayashi, Yoshinori Minami, Mutsuhiko Yokota, Shumpei |
| description | Adjuvants in vaccines are immune stimulants that play an important role in the induction of effective and appropriate immune responses to vaccine component(s). Diphtheria–tetanus–pertussis (DPT) vaccine contains not only aluminum hydrate (alum) to enhance the immune response to the vaccine ingredients, but also, both for that purpose and as a principal ingredient, pertussis toxin (PT). However, both adjuvants strongly promote T helper (Th) 2 type immune responses. Th1 and Th2 type immune responses are counterbalanced in vivo, and a Th2-prone immune response is not effective against intracellular infections but promotes IgE production, which is related to allergic disease. In this study, we used the CpG motif contained in oligodeoxynucleotide (CpG-ODN), which has an adjuvant effect and also induces the Th1 response, as an adjuvant to this vaccine, and we investigated its adjuvanticity and its potential to modulate immune responses to DPT vaccine. Administration of DPT vaccine with CpG-ODN (DPT-alum/ODN) to mice significantly reduced the total IgE levels and increased the anti-PT specific IgG2a titer in serum, in comparison with ordinary DPT vaccine (DPT-alum). Moreover, we investigated the antibody response to orally administrated ovalbumin (OVA) after vaccine administration. In the DPT-alum/ODN-administered group, the OVA specific IgE production in serum greatly decreased in comparison with that in the DPT-alum-administered group. These data indicate that CpG-ODN was not useful only as an efficient vaccine adjuvant but also shifted the immune responses substantially toward Th1 and modulated the Th1/Th2 immune response in DPT vaccine. These data suggested new applications of CpG-ODN as adjuvants in DPT vaccine. |
| doi_str_mv | 10.1016/j.vaccine.2004.09.041 |
| format | Article |
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Diphtheria–tetanus–pertussis (DPT) vaccine contains not only aluminum hydrate (alum) to enhance the immune response to the vaccine ingredients, but also, both for that purpose and as a principal ingredient, pertussis toxin (PT). However, both adjuvants strongly promote T helper (Th) 2 type immune responses. Th1 and Th2 type immune responses are counterbalanced in vivo, and a Th2-prone immune response is not effective against intracellular infections but promotes IgE production, which is related to allergic disease. In this study, we used the CpG motif contained in oligodeoxynucleotide (CpG-ODN), which has an adjuvant effect and also induces the Th1 response, as an adjuvant to this vaccine, and we investigated its adjuvanticity and its potential to modulate immune responses to DPT vaccine. Administration of DPT vaccine with CpG-ODN (DPT-alum/ODN) to mice significantly reduced the total IgE levels and increased the anti-PT specific IgG2a titer in serum, in comparison with ordinary DPT vaccine (DPT-alum). Moreover, we investigated the antibody response to orally administrated ovalbumin (OVA) after vaccine administration. In the DPT-alum/ODN-administered group, the OVA specific IgE production in serum greatly decreased in comparison with that in the DPT-alum-administered group. These data indicate that CpG-ODN was not useful only as an efficient vaccine adjuvant but also shifted the immune responses substantially toward Th1 and modulated the Th1/Th2 immune response in DPT vaccine. These data suggested new applications of CpG-ODN as adjuvants in DPT vaccine.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2004.09.041</identifier><identifier>PMID: 16006019</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adjuvant ; Adjuvants, Immunologic - pharmacology ; Alum ; Alum Compounds - pharmacology ; Aluminum ; Animals ; Antigens ; Antigens - administration & dosage ; Antigens - immunology ; Applied microbiology ; Bacterial diseases ; Bacterial infections ; Biological and medical sciences ; CpG Islands ; CpG motif ; Diphtheria ; Diphtheria-Tetanus-Pertussis Vaccine - immunology ; DPT vaccine ; Ent and stomatologic bacterial diseases ; Enzyme-Linked Immunosorbent Assay ; Experiments ; Female ; Fundamental and applied biological sciences. Psychology ; Human bacterial diseases ; Hypersensitivity - prevention & control ; Immune response ; Immune system ; Immunity, Cellular - drug effects ; Immunoglobulin G - analysis ; Immunoglobulin G - biosynthesis ; Infections ; Infectious diseases ; Intubation, Gastrointestinal ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Microbiology ; Mouse ; Oligonucleotides - pharmacology ; Ovalbumin - immunology ; Rodents ; Tetanus ; Th1 Cells - immunology ; Th1/Th2 ; Th2 Cells - immunology ; Toxins ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Viral infections</subject><ispartof>Vaccine, 2005-11, Vol.23 (46), p.5450-5456</ispartof><rights>2005 Elsevier Ltd</rights><rights>2006 INIST-CNRS</rights><rights>Copyright Elsevier Limited Nov 16, 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c485t-93263a396b9a48cb950fb03174092747991f47400a8e9ca101a22bec7a8069463</citedby><cites>FETCH-LOGICAL-c485t-93263a396b9a48cb950fb03174092747991f47400a8e9ca101a22bec7a8069463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1558985437?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17280420$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16006019$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sugai, Toshiyuki</creatorcontrib><creatorcontrib>Mori, Masaaki</creatorcontrib><creatorcontrib>Nakazawa, Masatoshi</creatorcontrib><creatorcontrib>Ichino, Motohide</creatorcontrib><creatorcontrib>Naruto, Takuya</creatorcontrib><creatorcontrib>Kobayashi, Naoki</creatorcontrib><creatorcontrib>Kobayashi, Yoshinori</creatorcontrib><creatorcontrib>Minami, Mutsuhiko</creatorcontrib><creatorcontrib>Yokota, Shumpei</creatorcontrib><title>A CpG-containing oligodeoxynucleotide as an efficient adjuvant counterbalancing the Th1/Th2 immune response in diphtheria–tetanus–pertussis vaccine</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Adjuvants in vaccines are immune stimulants that play an important role in the induction of effective and appropriate immune responses to vaccine component(s). Diphtheria–tetanus–pertussis (DPT) vaccine contains not only aluminum hydrate (alum) to enhance the immune response to the vaccine ingredients, but also, both for that purpose and as a principal ingredient, pertussis toxin (PT). However, both adjuvants strongly promote T helper (Th) 2 type immune responses. Th1 and Th2 type immune responses are counterbalanced in vivo, and a Th2-prone immune response is not effective against intracellular infections but promotes IgE production, which is related to allergic disease. In this study, we used the CpG motif contained in oligodeoxynucleotide (CpG-ODN), which has an adjuvant effect and also induces the Th1 response, as an adjuvant to this vaccine, and we investigated its adjuvanticity and its potential to modulate immune responses to DPT vaccine. Administration of DPT vaccine with CpG-ODN (DPT-alum/ODN) to mice significantly reduced the total IgE levels and increased the anti-PT specific IgG2a titer in serum, in comparison with ordinary DPT vaccine (DPT-alum). Moreover, we investigated the antibody response to orally administrated ovalbumin (OVA) after vaccine administration. In the DPT-alum/ODN-administered group, the OVA specific IgE production in serum greatly decreased in comparison with that in the DPT-alum-administered group. These data indicate that CpG-ODN was not useful only as an efficient vaccine adjuvant but also shifted the immune responses substantially toward Th1 and modulated the Th1/Th2 immune response in DPT vaccine. These data suggested new applications of CpG-ODN as adjuvants in DPT vaccine.</description><subject>Adjuvant</subject><subject>Adjuvants, Immunologic - pharmacology</subject><subject>Alum</subject><subject>Alum Compounds - pharmacology</subject><subject>Aluminum</subject><subject>Animals</subject><subject>Antigens</subject><subject>Antigens - administration & dosage</subject><subject>Antigens - immunology</subject><subject>Applied microbiology</subject><subject>Bacterial diseases</subject><subject>Bacterial infections</subject><subject>Biological and medical sciences</subject><subject>CpG Islands</subject><subject>CpG motif</subject><subject>Diphtheria</subject><subject>Diphtheria-Tetanus-Pertussis Vaccine - immunology</subject><subject>DPT vaccine</subject><subject>Ent and stomatologic bacterial diseases</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Experiments</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human bacterial diseases</subject><subject>Hypersensitivity - prevention & control</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunity, Cellular - drug effects</subject><subject>Immunoglobulin G - analysis</subject><subject>Immunoglobulin G - biosynthesis</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Intubation, Gastrointestinal</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Microbiology</subject><subject>Mouse</subject><subject>Oligonucleotides - pharmacology</subject><subject>Ovalbumin - immunology</subject><subject>Rodents</subject><subject>Tetanus</subject><subject>Th1 Cells - immunology</subject><subject>Th1/Th2</subject><subject>Th2 Cells - immunology</subject><subject>Toxins</subject><subject>Vaccines</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><subject>Viral infections</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFksGKFDEQhhtR3HH1EZSAKF56ttKd7k5Osgy6CgteRvAW0unqnQw9SZukB_fmO-xh388nMc00LHhwT6nAV0X99f9Z9prCmgKtL_bro9LaWFwXAGwNYg2MPslWlDdlXlSUP81WUNQsZxR-nGUvQtgDQFVS8Tw7ozVADVSssvtLshmvcu1sVMYae0PcYG5ch-7XrZ30gC6aDokKRFmCfW-0QRuJ6vbTUaVCu8lG9K0alNVze9wh2e7oxXZXEHM4TBaJxzA6G5AYSzoz7hLijfrz-y5iVHYKqRrRxykEE8ii6mX2rFdDwFfLe559__xpu_mSX3-7-rq5vM4141XMRVnUpSpF3QrFuG5FBX0LJW0YiKJhjRC0Z-kDiqPQKl1OFUWLulEcasHq8jx7f5o7evdzwhDlwQSNQ5KDbgqy5hzmaY-CtClYKaoqgR_-D1YATVPzWiT07T_o3k3eJr2JqrjgFSubRFUnSnsXgsdejt4clL-VFOScBbmXy9XknAUJQqYspL43y_SpPWD30LWYn4B3C6CCVkPvZwvDA9cUHFgxS_944jAZcTToZZhToLEzHnWUnTOPrPIXdZ3Xaw</recordid><startdate>20051116</startdate><enddate>20051116</enddate><creator>Sugai, Toshiyuki</creator><creator>Mori, Masaaki</creator><creator>Nakazawa, Masatoshi</creator><creator>Ichino, Motohide</creator><creator>Naruto, Takuya</creator><creator>Kobayashi, Naoki</creator><creator>Kobayashi, Yoshinori</creator><creator>Minami, Mutsuhiko</creator><creator>Yokota, Shumpei</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20051116</creationdate><title>A CpG-containing oligodeoxynucleotide as an efficient adjuvant counterbalancing the Th1/Th2 immune response in diphtheria–tetanus–pertussis vaccine</title><author>Sugai, Toshiyuki ; Mori, Masaaki ; Nakazawa, Masatoshi ; Ichino, Motohide ; Naruto, Takuya ; Kobayashi, Naoki ; Kobayashi, Yoshinori ; Minami, Mutsuhiko ; Yokota, Shumpei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c485t-93263a396b9a48cb950fb03174092747991f47400a8e9ca101a22bec7a8069463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adjuvant</topic><topic>Adjuvants, Immunologic - pharmacology</topic><topic>Alum</topic><topic>Alum Compounds - pharmacology</topic><topic>Aluminum</topic><topic>Animals</topic><topic>Antigens</topic><topic>Antigens - administration & dosage</topic><topic>Antigens - immunology</topic><topic>Applied microbiology</topic><topic>Bacterial diseases</topic><topic>Bacterial infections</topic><topic>Biological and medical sciences</topic><topic>CpG Islands</topic><topic>CpG motif</topic><topic>Diphtheria</topic><topic>Diphtheria-Tetanus-Pertussis Vaccine - immunology</topic><topic>DPT vaccine</topic><topic>Ent and stomatologic bacterial diseases</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Experiments</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Human bacterial diseases</topic><topic>Hypersensitivity - prevention & control</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunity, Cellular - drug effects</topic><topic>Immunoglobulin G - analysis</topic><topic>Immunoglobulin G - biosynthesis</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Intubation, Gastrointestinal</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Microbiology</topic><topic>Mouse</topic><topic>Oligonucleotides - pharmacology</topic><topic>Ovalbumin - immunology</topic><topic>Rodents</topic><topic>Tetanus</topic><topic>Th1 Cells - immunology</topic><topic>Th1/Th2</topic><topic>Th2 Cells - immunology</topic><topic>Toxins</topic><topic>Vaccines</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><topic>Viral infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sugai, Toshiyuki</creatorcontrib><creatorcontrib>Mori, Masaaki</creatorcontrib><creatorcontrib>Nakazawa, Masatoshi</creatorcontrib><creatorcontrib>Ichino, Motohide</creatorcontrib><creatorcontrib>Naruto, Takuya</creatorcontrib><creatorcontrib>Kobayashi, Naoki</creatorcontrib><creatorcontrib>Kobayashi, Yoshinori</creatorcontrib><creatorcontrib>Minami, Mutsuhiko</creatorcontrib><creatorcontrib>Yokota, Shumpei</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sugai, Toshiyuki</au><au>Mori, Masaaki</au><au>Nakazawa, Masatoshi</au><au>Ichino, Motohide</au><au>Naruto, Takuya</au><au>Kobayashi, Naoki</au><au>Kobayashi, Yoshinori</au><au>Minami, Mutsuhiko</au><au>Yokota, Shumpei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A CpG-containing oligodeoxynucleotide as an efficient adjuvant counterbalancing the Th1/Th2 immune response in diphtheria–tetanus–pertussis vaccine</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2005-11-16</date><risdate>2005</risdate><volume>23</volume><issue>46</issue><spage>5450</spage><epage>5456</epage><pages>5450-5456</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>Adjuvants in vaccines are immune stimulants that play an important role in the induction of effective and appropriate immune responses to vaccine component(s). Diphtheria–tetanus–pertussis (DPT) vaccine contains not only aluminum hydrate (alum) to enhance the immune response to the vaccine ingredients, but also, both for that purpose and as a principal ingredient, pertussis toxin (PT). However, both adjuvants strongly promote T helper (Th) 2 type immune responses. Th1 and Th2 type immune responses are counterbalanced in vivo, and a Th2-prone immune response is not effective against intracellular infections but promotes IgE production, which is related to allergic disease. In this study, we used the CpG motif contained in oligodeoxynucleotide (CpG-ODN), which has an adjuvant effect and also induces the Th1 response, as an adjuvant to this vaccine, and we investigated its adjuvanticity and its potential to modulate immune responses to DPT vaccine. Administration of DPT vaccine with CpG-ODN (DPT-alum/ODN) to mice significantly reduced the total IgE levels and increased the anti-PT specific IgG2a titer in serum, in comparison with ordinary DPT vaccine (DPT-alum). Moreover, we investigated the antibody response to orally administrated ovalbumin (OVA) after vaccine administration. In the DPT-alum/ODN-administered group, the OVA specific IgE production in serum greatly decreased in comparison with that in the DPT-alum-administered group. These data indicate that CpG-ODN was not useful only as an efficient vaccine adjuvant but also shifted the immune responses substantially toward Th1 and modulated the Th1/Th2 immune response in DPT vaccine. These data suggested new applications of CpG-ODN as adjuvants in DPT vaccine.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>16006019</pmid><doi>10.1016/j.vaccine.2004.09.041</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Vaccine, 2005-11, Vol.23 (46), p.5450-5456 |
| issn | 0264-410X 1873-2518 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier); ProQuest Central UK/Ireland |
| subjects | Adjuvant Adjuvants, Immunologic - pharmacology Alum Alum Compounds - pharmacology Aluminum Animals Antigens Antigens - administration & dosage Antigens - immunology Applied microbiology Bacterial diseases Bacterial infections Biological and medical sciences CpG Islands CpG motif Diphtheria Diphtheria-Tetanus-Pertussis Vaccine - immunology DPT vaccine Ent and stomatologic bacterial diseases Enzyme-Linked Immunosorbent Assay Experiments Female Fundamental and applied biological sciences. Psychology Human bacterial diseases Hypersensitivity - prevention & control Immune response Immune system Immunity, Cellular - drug effects Immunoglobulin G - analysis Immunoglobulin G - biosynthesis Infections Infectious diseases Intubation, Gastrointestinal Medical sciences Mice Mice, Inbred BALB C Microbiology Mouse Oligonucleotides - pharmacology Ovalbumin - immunology Rodents Tetanus Th1 Cells - immunology Th1/Th2 Th2 Cells - immunology Toxins Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Viral infections |
| title | A CpG-containing oligodeoxynucleotide as an efficient adjuvant counterbalancing the Th1/Th2 immune response in diphtheria–tetanus–pertussis vaccine |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T21%3A58%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20CpG-containing%20oligodeoxynucleotide%20as%20an%20efficient%20adjuvant%20counterbalancing%20the%20Th1/Th2%20immune%20response%20in%20diphtheria%E2%80%93tetanus%E2%80%93pertussis%20vaccine&rft.jtitle=Vaccine&rft.au=Sugai,%20Toshiyuki&rft.date=2005-11-16&rft.volume=23&rft.issue=46&rft.spage=5450&rft.epage=5456&rft.pages=5450-5456&rft.issn=0264-410X&rft.eissn=1873-2518&rft.coden=VACCDE&rft_id=info:doi/10.1016/j.vaccine.2004.09.041&rft_dat=%3Cproquest_cross%3E3420505401%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1558985437&rft_id=info:pmid/16006019&rft_els_id=S0264410X05005517&rfr_iscdi=true |