IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines

Cytokines of the interleukin-1 (IL-1) family, such as IL-1α/β and IL-18, have important functions in host defense, immune regulation, and inflammation. Insight into their biological functions has led to novel therapeutic approaches to treat human inflammatory diseases. Within the IL-1 family, IL-1α/...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2005-11, Vol.23 (5), p.479-490
Hauptverfasser:	Schmitz, Jochen, Owyang, Alexander, Oldham, Elizabeth, Song, Yaoli, Murphy, Erin, McClanahan, Terril K., Zurawski, Gerard, Moshrefi, Mehrdad, Qin, Jinzhong, Li, Xiaoxia, Gorman, Daniel M., Bazan, J. Fernando, Kastelein, Robert A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Cell Differentiation Cell Polarity Chromosomes Cytokines - genetics Cytokines - immunology Enzyme Activation Eosinophils - cytology Eosinophils - metabolism Gene expression Gene Expression Regulation Humans Interleukin-1 Receptor-Like 1 Protein Interleukin-33 Interleukins - chemistry Interleukins - classification Interleukins - genetics Interleukins - immunology Kinases Ligands Mast Cells - metabolism Membrane Proteins - immunology Mice Mitogen-Activated Protein Kinases - metabolism Molecular Sequence Data NF-kappa B - metabolism Phosphorylation Phylogeny Proteins Receptors, Cell Surface Receptors, Interleukin Receptors, Interleukin-1 - immunology Sequence Alignment Sequence Homology, Amino Acid Signal Transduction Spleen - cytology Spleen - immunology Spleen - metabolism Th2 Cells - cytology Th2 Cells - immunology Transcription factors
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