Acute Glutathione Depletion Restricts Mitochondrial ATP Export in Cerebellar Granule Neurons

Decreases in GSH pools detected during ischemia sensitize neurons to excitotoxic damage. Thermodynamic analysis predicts that partial GSH depletion will cause an oxidative shift in the thiol redox potential. To investigate the acute bioenergetic consequences, neurons were exposed to monochlorobimane...

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Veröffentlicht in:	The Journal of biological chemistry 2005-11, Vol.280 (46), p.38720-38728
Hauptverfasser:	Vesce, Sabino, Jekabsons, Mika B., Johnson-Cadwell, Linda I., Nicholls, David G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Nucleotide Translocator 1 - antagonists & inhibitors Adenosine Diphosphate - chemistry Adenosine Triphosphate - chemistry Animals Biological Transport Bongkrekic Acid - pharmacology Buffers Calcium - metabolism Cell Death Cell Membrane - metabolism Cell Respiration Cerebellum - metabolism Cytoplasm - metabolism Fluorescent Dyes - pharmacology Glutathione - chemistry Glutathione - metabolism Glycolysis Green Fluorescent Proteins - chemistry Green Fluorescent Proteins - metabolism Guanosine Triphosphate - chemistry Immunohistochemistry Ions Kainic Acid - pharmacology Membrane Potentials Microscopy, Confocal Mitochondria - metabolism Neurons - metabolism Oligomycins - pharmacology Oxidation-Reduction Oxygen - chemistry Pyrazoles - chemistry Pyrazoles - pharmacology Rats Rats, Wistar Rhodamine 123 - pharmacology Sodium - chemistry Submitochondrial Particles - metabolism Thermodynamics Time Factors Transfection
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