Room Temperature Intramolecular Hydro-O-alkylation of Aldehydes:  sp3 C−H Functionalization via a Lewis Acid Catalyzed Tandem 1,5-Hydride Transfer/Cyclization

The scope and limitations of intramolecular hydro-O-alkylation of aldehyde substrates leading to spiroketals and bicyclic ketals and aminals is reported. The direct transformation of tertiary and sterically hindered secondary sp3 C−H bonds into C−O bonds under the action of a catalytic amount of a v...

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Veröffentlicht in:	Organic letters 2005-11, Vol.7 (24), p.5429-5431
Hauptverfasser:	Pastine, Stefan J, Sames, Dalibor
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes - chemistry Alkylation Catalysis Cyclization Indicators and Reagents Molecular Structure Temperature
Online-Zugang:	Volltext
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