Aluminium phosphate potentiates the efficacy of DNA vaccines against Leishmania mexicana

DNA vaccines have been able to induce partial protection against infection with Leishmania in mice, but it is still necessary to increase their efficacy. In the present study we evaluated aluminium phosphate as an adjuvant of different formulations and doses of DNA vaccines against L. mexicana in BA...

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Veröffentlicht in:	Vaccine 2005-11, Vol.23 (46), p.5372-5379
Hauptverfasser:	Rosado-Vallado, Miguel, Mut-Martin, Mirza, García-Miss, Maria del Rosario, Dumonteil, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant Adjuvants, Immunologic - pharmacology Adsorption Aluminum Compounds - pharmacology Animals Antibodies, Protozoan - immunology Applied microbiology Biological and medical sciences CD4-CD8 Ratio Cell Proliferation - drug effects Chemistry, Pharmaceutical DNA vaccine Female Fundamental and applied biological sciences. Psychology Interferon-gamma - biosynthesis Kinetics Leishmania Leishmania donovani Leishmania donovani - immunology Leishmania mexicana Leishmania mexicana - genetics Leishmania mexicana - immunology Leishmaniasis, Cutaneous - immunology Leishmaniasis, Cutaneous - prevention & control Lymphocytes - drug effects Lymphocytes - immunology Mice Mice, Inbred BALB C Microbiology Phosphates - pharmacology Plasmids - genetics Protozoan Vaccines - genetics Protozoan Vaccines - immunology Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, DNA - genetics Vaccines, DNA - immunology
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