Inhibition of thromboxane biosynthesis by triflusal in type 2 diabetes mellitus

Triflusal is an antiplatelet drug related to aspirin, with different pharmacological properties and a lower haemorrhagic risk. We aimed at comparing their effects on platelet and endothelial activation in type 2 diabetes mellitus (T2DM). In a randomized, double-blind, parallel group study, we compar...

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Veröffentlicht in:	Atherosclerosis 2005-12, Vol.183 (2), p.329-335
Hauptverfasser:	Falco, A., Salvati, F., Vitacolonna, E., Avellone, G., Pinto, A., Di Febbo, C., Ballone, E., Di Nicola, M., Ciabattoni, G., Davì, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aspirin Aspirin - administration & dosage Aspirin - therapeutic use Associated diseases and complications Atherosclerosis (general aspects, experimental research) Biological and medical sciences Biomarkers - blood Biomarkers - urine Blood and lymphatic vessels Blood vessels and receptors Cardiology. Vascular system Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - urine Diabetes. Impaired glucose tolerance Dose-Response Relationship, Drug Double-Blind Method Endocrine pancreas. Apud cells (diseases) Endocrinopathies Female Follow-Up Studies Fundamental and applied biological sciences. Psychology Humans Male Management. Various non-drug treatments. Langerhans islet grafts Medical sciences Middle Aged P-Selectin - blood P-Selectin - drug effects Platelet activation Platelet Activation - drug effects Platelet Aggregation Inhibitors - administration & dosage Platelet Aggregation Inhibitors - therapeutic use Radioimmunoassay Retrospective Studies Salicylates - administration & dosage Salicylates - therapeutic use Thromboxane B2 - analogs & derivatives Thromboxane B2 - antagonists & inhibitors Thromboxane B2 - biosynthesis Thromboxane B2 - urine Triflusal Type 2 diabetes mellitus Vertebrates: cardiovascular system von Willebrand Factor - drug effects von Willebrand Factor - metabolism
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