Isolation and Characterization of the B-Cell Marker CD20

The integral membrane protein CD20 has been identified as an important therapeutic target in the treatment of non-Hodgkin's lymphoma (NHL). CD20 binding of many antibodies including the therapeutic antibody, rituximab, has been shown to be critically dependent upon the conformation of a loop st...

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Veröffentlicht in:	Biochemistry (Easton) 2005-11, Vol.44 (46), p.15150-15158
Hauptverfasser:	Ernst, James A, Li, Hong, Kim, Hok Seon, Nakamura, Gerald R, Yansura, Daniel G, Vandlen, Richard L
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies, Monoclonal - metabolism Antibodies, Monoclonal, Murine-Derived Antigen-Antibody Reactions Antigens, CD20 - chemistry Antigens, CD20 - isolation & purification Antigens, CD20 - metabolism B-Lymphocytes - chemistry B-Lymphocytes - metabolism Cell Membrane - chemistry Circular Dichroism Cloning, Molecular Enzyme-Linked Immunosorbent Assay Escherichia coli - metabolism Humans Mice Molecular Sequence Data Protein Conformation Recombinant Proteins - isolation & purification Recombinant Proteins - metabolism Rituximab
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