Circulating levels of MCP-1 and eotaxin are not associated with presence of atherosclerosis or previous myocardial infarction
The chemokines are a family of signalling proteins that participate in regulation of the immune system and have been implicated in the pathogenesis of vascular diseases. Deleting the gene encoding the chemokine MCP-1 in mouse models of atherosclerosis reduces lipid lesion formation and circulating c...
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| Veröffentlicht in: | Atherosclerosis 2005-12, Vol.183 (2), p.268-274 |
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| creator | Mosedale, David E. Smith, Duncan J. Aitken, Sri Schofield, Peter M. Clarke, Sarah C. McNab, Duncan Goddard, Hester Gale, Catharine R. Martyn, Christopher N. Bethell, Hugh W.L. Barnard, Caryl Hayns, Sarah Nugent, Claire Panicker, Annik Grainger, David J. |
| description | The chemokines are a family of signalling proteins that participate in regulation of the immune system and have been implicated in the pathogenesis of vascular diseases. Deleting the gene encoding the chemokine MCP-1 in mouse models of atherosclerosis reduces lipid lesion formation and circulating chemokines are upregulated in man immediately following myocardial infarction (MI) or coronary angioplasty. We have therefore investigated whether circulating levels of two chemokines (MCP-1 and eotaxin) differ between subjects with and without atherosclerosis. We have used three different methods of measuring the presence and extent of atherosclerosis in human subjects: duplex ultrasonography of the carotid arteries and clinical diagnosis of coronary heart disease on individuals from the general population and coronary angiography on patients with suspected heart disease. There was no difference in the levels of circulating MCP-1 or eotaxin, measured by ELISA, between subjects with and without atherosclerosis. Furthermore, any increase in circulating MCP-1 following acute MI must be short-lived, since chemokine levels were not different in subjects who had had an MI previously compared to those who had not. We conclude that although there may be a transient increase in circulating chemokine levels following coronary angioplasty, there is no difference in the levels of circulating MCP-1 or eotaxin in subjects with and without atherosclerosis. |
| doi_str_mv | 10.1016/j.atherosclerosis.2004.11.028 |
| format | Article |
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Deleting the gene encoding the chemokine MCP-1 in mouse models of atherosclerosis reduces lipid lesion formation and circulating chemokines are upregulated in man immediately following myocardial infarction (MI) or coronary angioplasty. We have therefore investigated whether circulating levels of two chemokines (MCP-1 and eotaxin) differ between subjects with and without atherosclerosis. We have used three different methods of measuring the presence and extent of atherosclerosis in human subjects: duplex ultrasonography of the carotid arteries and clinical diagnosis of coronary heart disease on individuals from the general population and coronary angiography on patients with suspected heart disease. There was no difference in the levels of circulating MCP-1 or eotaxin, measured by ELISA, between subjects with and without atherosclerosis. Furthermore, any increase in circulating MCP-1 following acute MI must be short-lived, since chemokine levels were not different in subjects who had had an MI previously compared to those who had not. We conclude that although there may be a transient increase in circulating chemokine levels following coronary angioplasty, there is no difference in the levels of circulating MCP-1 or eotaxin in subjects with and without atherosclerosis.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/j.atherosclerosis.2004.11.028</identifier><identifier>PMID: 15894320</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ireland Ltd</publisher><subject>Aged ; Angiography ; Atherosclerosis (general aspects, experimental research) ; Atherosclerosis - blood ; Atherosclerosis - diagnostic imaging ; Atherosclerosis - physiopathology ; Biological and medical sciences ; Biomarkers - blood ; Blood and lymphatic vessels ; Blood Flow Velocity ; Cardiology. Vascular system ; Carotid Artery Diseases - blood ; Carotid Artery Diseases - diagnostic imaging ; Carotid Artery Diseases - physiopathology ; Chemokine ; Chemokine CCL11 ; Chemokine CCL2 - blood ; Chemokines, CC - blood ; Chemotactic Factors, Eosinophil - blood ; Coronary Angiography ; Coronary artery disease ; Coronary Artery Disease - blood ; Coronary Artery Disease - diagnostic imaging ; Coronary heart disease ; Cytokine ; Diseases of the aorta ; Female ; Follow-Up Studies ; Heart ; Humans ; Immunology ; Male ; Medical sciences ; Myocardial Infarction - blood ; Myocardial Infarction - diagnostic imaging ; Neurology ; Prognosis ; Severity of Illness Index ; Ultrasonography, Doppler, Color ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Atherosclerosis, 2005-12, Vol.183 (2), p.268-274</ispartof><rights>2005 Elsevier Ireland Ltd</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-c27e5dff0f374e5cba6676f9a18d4d6e9f2b05f088ac505050819b7e65e055b23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0021915005002352$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17262630$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15894320$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mosedale, David E.</creatorcontrib><creatorcontrib>Smith, Duncan J.</creatorcontrib><creatorcontrib>Aitken, Sri</creatorcontrib><creatorcontrib>Schofield, Peter M.</creatorcontrib><creatorcontrib>Clarke, Sarah C.</creatorcontrib><creatorcontrib>McNab, Duncan</creatorcontrib><creatorcontrib>Goddard, Hester</creatorcontrib><creatorcontrib>Gale, Catharine R.</creatorcontrib><creatorcontrib>Martyn, Christopher N.</creatorcontrib><creatorcontrib>Bethell, Hugh W.L.</creatorcontrib><creatorcontrib>Barnard, Caryl</creatorcontrib><creatorcontrib>Hayns, Sarah</creatorcontrib><creatorcontrib>Nugent, Claire</creatorcontrib><creatorcontrib>Panicker, Annik</creatorcontrib><creatorcontrib>Grainger, David J.</creatorcontrib><title>Circulating levels of MCP-1 and eotaxin are not associated with presence of atherosclerosis or previous myocardial infarction</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description>The chemokines are a family of signalling proteins that participate in regulation of the immune system and have been implicated in the pathogenesis of vascular diseases. Deleting the gene encoding the chemokine MCP-1 in mouse models of atherosclerosis reduces lipid lesion formation and circulating chemokines are upregulated in man immediately following myocardial infarction (MI) or coronary angioplasty. We have therefore investigated whether circulating levels of two chemokines (MCP-1 and eotaxin) differ between subjects with and without atherosclerosis. We have used three different methods of measuring the presence and extent of atherosclerosis in human subjects: duplex ultrasonography of the carotid arteries and clinical diagnosis of coronary heart disease on individuals from the general population and coronary angiography on patients with suspected heart disease. There was no difference in the levels of circulating MCP-1 or eotaxin, measured by ELISA, between subjects with and without atherosclerosis. Furthermore, any increase in circulating MCP-1 following acute MI must be short-lived, since chemokine levels were not different in subjects who had had an MI previously compared to those who had not. We conclude that although there may be a transient increase in circulating chemokine levels following coronary angioplasty, there is no difference in the levels of circulating MCP-1 or eotaxin in subjects with and without atherosclerosis.</description><subject>Aged</subject><subject>Angiography</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Atherosclerosis - blood</subject><subject>Atherosclerosis - diagnostic imaging</subject><subject>Atherosclerosis - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Flow Velocity</subject><subject>Cardiology. Vascular system</subject><subject>Carotid Artery Diseases - blood</subject><subject>Carotid Artery Diseases - diagnostic imaging</subject><subject>Carotid Artery Diseases - physiopathology</subject><subject>Chemokine</subject><subject>Chemokine CCL11</subject><subject>Chemokine CCL2 - blood</subject><subject>Chemokines, CC - blood</subject><subject>Chemotactic Factors, Eosinophil - blood</subject><subject>Coronary Angiography</subject><subject>Coronary artery disease</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary heart disease</subject><subject>Cytokine</subject><subject>Diseases of the aorta</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart</subject><subject>Humans</subject><subject>Immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Myocardial Infarction - blood</subject><subject>Myocardial Infarction - diagnostic imaging</subject><subject>Neurology</subject><subject>Prognosis</subject><subject>Severity of Illness Index</subject><subject>Ultrasonography, Doppler, Color</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcFu1DAQhi1ERZfCKyBfyi3B400c58ABraAgFdEDnK2JM6ZeZePF9hZ66LvjaFcg9VRZsg_-ZvzPZ8YuQdQgQL3b1phvKYZkp2X3qZZCNDVALaR-xlagu76CRjfP2UoICVUPrThnL1PaigJ2oF-wc2h136ylWLGHjY_2MGH2808-0R1NiQfHv25uKuA4j5xCxj9-5hiJzyFzTClYj5lG_tvnW76PlGi2tFQ9SsZDXK7vfDgkvrsPFuPoceJ-dhht9mF-xc4cTolen84L9uPTx--bz9X1t6svmw_XlW2gy5WVHbWjc8Ktu4ZaO6BSnXI9gh6bUVHv5CBaJ7RG24plaeiHjlRLom0Hub5gb4999zH8OlDKZueTpWnCmUo4o4o0rWAB3x9BWyZIkZzZR7_DeG9AmMW_2ZpHU5rFvwEwxX-pf3N66DDsaPxffRJegMsTgMni5CLOtvT4x3VSSbVeuKsjVz6kGKRokvWL59FHstmMwT8x0l9gq7A_</recordid><startdate>20051201</startdate><enddate>20051201</enddate><creator>Mosedale, David E.</creator><creator>Smith, Duncan J.</creator><creator>Aitken, Sri</creator><creator>Schofield, Peter M.</creator><creator>Clarke, Sarah C.</creator><creator>McNab, Duncan</creator><creator>Goddard, Hester</creator><creator>Gale, Catharine R.</creator><creator>Martyn, Christopher N.</creator><creator>Bethell, Hugh W.L.</creator><creator>Barnard, Caryl</creator><creator>Hayns, Sarah</creator><creator>Nugent, Claire</creator><creator>Panicker, Annik</creator><creator>Grainger, David J.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20051201</creationdate><title>Circulating levels of MCP-1 and eotaxin are not associated with presence of atherosclerosis or previous myocardial infarction</title><author>Mosedale, David E. ; Smith, Duncan J. ; Aitken, Sri ; Schofield, Peter M. ; Clarke, Sarah C. ; McNab, Duncan ; Goddard, Hester ; Gale, Catharine R. ; Martyn, Christopher N. ; Bethell, Hugh W.L. ; Barnard, Caryl ; Hayns, Sarah ; Nugent, Claire ; Panicker, Annik ; Grainger, David J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-c27e5dff0f374e5cba6676f9a18d4d6e9f2b05f088ac505050819b7e65e055b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aged</topic><topic>Angiography</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Atherosclerosis - blood</topic><topic>Atherosclerosis - diagnostic imaging</topic><topic>Atherosclerosis - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Flow Velocity</topic><topic>Cardiology. Vascular system</topic><topic>Carotid Artery Diseases - blood</topic><topic>Carotid Artery Diseases - diagnostic imaging</topic><topic>Carotid Artery Diseases - physiopathology</topic><topic>Chemokine</topic><topic>Chemokine CCL11</topic><topic>Chemokine CCL2 - blood</topic><topic>Chemokines, CC - blood</topic><topic>Chemotactic Factors, Eosinophil - blood</topic><topic>Coronary Angiography</topic><topic>Coronary artery disease</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>Coronary heart disease</topic><topic>Cytokine</topic><topic>Diseases of the aorta</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Heart</topic><topic>Humans</topic><topic>Immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Myocardial Infarction - blood</topic><topic>Myocardial Infarction - diagnostic imaging</topic><topic>Neurology</topic><topic>Prognosis</topic><topic>Severity of Illness Index</topic><topic>Ultrasonography, Doppler, Color</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mosedale, David E.</creatorcontrib><creatorcontrib>Smith, Duncan J.</creatorcontrib><creatorcontrib>Aitken, Sri</creatorcontrib><creatorcontrib>Schofield, Peter M.</creatorcontrib><creatorcontrib>Clarke, Sarah C.</creatorcontrib><creatorcontrib>McNab, Duncan</creatorcontrib><creatorcontrib>Goddard, Hester</creatorcontrib><creatorcontrib>Gale, Catharine R.</creatorcontrib><creatorcontrib>Martyn, Christopher N.</creatorcontrib><creatorcontrib>Bethell, Hugh W.L.</creatorcontrib><creatorcontrib>Barnard, Caryl</creatorcontrib><creatorcontrib>Hayns, Sarah</creatorcontrib><creatorcontrib>Nugent, Claire</creatorcontrib><creatorcontrib>Panicker, Annik</creatorcontrib><creatorcontrib>Grainger, David J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mosedale, David E.</au><au>Smith, Duncan J.</au><au>Aitken, Sri</au><au>Schofield, Peter M.</au><au>Clarke, Sarah C.</au><au>McNab, Duncan</au><au>Goddard, Hester</au><au>Gale, Catharine R.</au><au>Martyn, Christopher N.</au><au>Bethell, Hugh W.L.</au><au>Barnard, Caryl</au><au>Hayns, Sarah</au><au>Nugent, Claire</au><au>Panicker, Annik</au><au>Grainger, David J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating levels of MCP-1 and eotaxin are not associated with presence of atherosclerosis or previous myocardial infarction</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>2005-12-01</date><risdate>2005</risdate><volume>183</volume><issue>2</issue><spage>268</spage><epage>274</epage><pages>268-274</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract>The chemokines are a family of signalling proteins that participate in regulation of the immune system and have been implicated in the pathogenesis of vascular diseases. Deleting the gene encoding the chemokine MCP-1 in mouse models of atherosclerosis reduces lipid lesion formation and circulating chemokines are upregulated in man immediately following myocardial infarction (MI) or coronary angioplasty. We have therefore investigated whether circulating levels of two chemokines (MCP-1 and eotaxin) differ between subjects with and without atherosclerosis. We have used three different methods of measuring the presence and extent of atherosclerosis in human subjects: duplex ultrasonography of the carotid arteries and clinical diagnosis of coronary heart disease on individuals from the general population and coronary angiography on patients with suspected heart disease. There was no difference in the levels of circulating MCP-1 or eotaxin, measured by ELISA, between subjects with and without atherosclerosis. Furthermore, any increase in circulating MCP-1 following acute MI must be short-lived, since chemokine levels were not different in subjects who had had an MI previously compared to those who had not. We conclude that although there may be a transient increase in circulating chemokine levels following coronary angioplasty, there is no difference in the levels of circulating MCP-1 or eotaxin in subjects with and without atherosclerosis.</abstract><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>15894320</pmid><doi>10.1016/j.atherosclerosis.2004.11.028</doi><tpages>7</tpages></addata></record> |
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| ispartof | Atherosclerosis, 2005-12, Vol.183 (2), p.268-274 |
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| subjects | Aged Angiography Atherosclerosis (general aspects, experimental research) Atherosclerosis - blood Atherosclerosis - diagnostic imaging Atherosclerosis - physiopathology Biological and medical sciences Biomarkers - blood Blood and lymphatic vessels Blood Flow Velocity Cardiology. Vascular system Carotid Artery Diseases - blood Carotid Artery Diseases - diagnostic imaging Carotid Artery Diseases - physiopathology Chemokine Chemokine CCL11 Chemokine CCL2 - blood Chemokines, CC - blood Chemotactic Factors, Eosinophil - blood Coronary Angiography Coronary artery disease Coronary Artery Disease - blood Coronary Artery Disease - diagnostic imaging Coronary heart disease Cytokine Diseases of the aorta Female Follow-Up Studies Heart Humans Immunology Male Medical sciences Myocardial Infarction - blood Myocardial Infarction - diagnostic imaging Neurology Prognosis Severity of Illness Index Ultrasonography, Doppler, Color Vascular diseases and vascular malformations of the nervous system |
| title | Circulating levels of MCP-1 and eotaxin are not associated with presence of atherosclerosis or previous myocardial infarction |
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