A novel role of L-serine (L-Ser) for the expression of nuclear factor of activated T cells (NFAT)2 in receptor activator of nuclear factor kappa B ligand (RANKL)-induced osteoclastogenesis in vitro

Multinucleated cell formation is crucial for osteoclastogenesis, and the expression of nuclear factor of activated T cells (NFAT)2 (NFATc1) is essential for this process. We previously found, using mouse RAW264 cells, that culture at high cell density blocked progression to the multinucleated cell s...

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Veröffentlicht in:	Journal of bone and mineral metabolism 2006-09, Vol.24 (5), p.373-379
Hauptverfasser:	Ogawa, Takuya, Ishida-Kitagawa, Norihiro, Tanaka, Akira, Matsumoto, Takahiro, Hirouchi, Tamayo, Akimaru, Mai, Tanihara, Masao, Yogo, Keiichiro, Takeya, Tatsuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins - physiology Cell Differentiation - physiology Cell Line Macrophages - physiology Membrane Glycoproteins - physiology Mice NFATC Transcription Factors - biosynthesis NFATC Transcription Factors - genetics Osteoclasts - cytology RANK Ligand Receptor Activator of Nuclear Factor-kappa B Serine - physiology
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