The Roles of Cyclin-dependent Kinase 5 and Glycogen Synthase Kinase 3 in Tau Hyperphosphorylation

Hyperphosphorylation of the microtubule-associated protein tau is a characteristic feature of neurodegenerative tauopathies including Alzheimer disease. Over-activation of proline-directed kinases, such as cyclin-dependent kinase 5 (Cdk5) and glycogen synthase kinase 3 (GSK3), has been implicated in...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The Journal of biological chemistry 2006-09, Vol.281 (35), p.25457-25465
Hauptverfasser:	Plattner, Florian, Angelo, Marco, Giese, K. Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cyclin-Dependent Kinase 5 - physiology Epitopes Gene Expression Regulation Glycogen Synthase Kinase 3 - physiology Heterozygote Hippocampus - metabolism Mice Mice, Inbred C57BL Mice, Transgenic Phosphoproteins - metabolism Phosphorylation Proline - chemistry tau Proteins - chemistry tau Proteins - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!