Hypothalamic pro-opiomelanocortin gene delivery ameliorates obesity and glucose intolerance in aged rats

Age-related obesity is associated with impaired hypothalamic pro-opiomelanocortin (Pomc) gene expression. We assessed whether overproduction of POMC in the hypothalamus ameliorates age-related obesity in rats. Recombinant adeno-associated virus (rAAV) encoding Pomc (rAAV-Pomc) or control vector was...

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Veröffentlicht in:	Diabetologia 2005-11, Vol.48 (11), p.2376-2385
Hauptverfasser:	LI, G, ZHANG, Y, WILSEY, J. T, SCARPACE, P. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue, Brown - drug effects Adipose Tissue, Brown - metabolism Age Aging Aging - physiology Agouti-Related Protein Animals Anorexia Biological and medical sciences Body fat Body Weight - genetics Cholesterol - blood Dependovirus - genetics Diabetes Diabetes. Impaired glucose tolerance Eating Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fatty Acids, Nonesterified - blood Gene therapy Genetic Therapy - methods Genetic Vectors - genetics Genetic Vectors - pharmacology Glucose Glucose - metabolism Glucose Intolerance - genetics Glucose Tolerance Test - methods Hypothalamus Hypothalamus - drug effects Insulin resistance Intercellular Signaling Peptides and Proteins Leptin - blood Male Medical sciences Metabolic diseases Metabolism Mutation Neuropeptide Y - drug effects Neuropeptide Y - genetics Neuropeptides Obesity Obesity - genetics Obesity - metabolism Obesity - therapy Peptide Hormones - drug effects Peptide Hormones - genetics Pro-Opiomelanocortin - administration & dosage Pro-Opiomelanocortin - genetics Proteins Rats Rats, Inbred F344 Receptor, Melanocortin, Type 3 - drug effects Receptor, Melanocortin, Type 3 - genetics Receptor, Melanocortin, Type 4 - drug effects Receptor, Melanocortin, Type 4 - genetics Thermogenesis Triglycerides - blood
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